دورية أكاديمية
Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
| العنوان: | Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype. |
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| المؤلفون: | Saldin LT; 1 Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Patel S; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Zhang L; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Huleihel L; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Hussey GS; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Nascari DG; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Quijano LM; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Li X; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Raghu D; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Bajwa AK; 1 Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Smith NG; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Chung CC; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Omstead AN; 3 Esophageal and Lung Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Kosovec JE; 3 Esophageal and Lung Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Jobe BA; 3 Esophageal and Lung Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Turner NJ; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; 4 Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania., Zaidi AH; 3 Esophageal and Lung Institute, Allegheny Health Network, Pittsburgh, Pennsylvania., Badylak SF; 2 McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.; 4 Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania. |
| المصدر: | Tissue engineering. Part A [Tissue Eng Part A] 2019 Mar; Vol. 25 (5-6), pp. 487-498. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101466659 Publication Model: Print Cited Medium: Internet ISSN: 1937-335X (Electronic) Linking ISSN: 19373341 NLM ISO Abbreviation: Tissue Eng Part A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New Rochelle, NY : Mary Ann Liebert, Inc. |
| مواضيع طبية MeSH: | Down-Regulation*, Esophageal Neoplasms/*pathology , Extracellular Matrix/*metabolism, Animals ; Apoptosis ; Autophagy ; Cell Cycle ; Cell Line, Tumor ; Cell Proliferation ; Cell Shape ; DNA Replication ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Phenotype ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction ; Swine ; Urinary Bladder/metabolism |
| مستخلص: | Impact Statement: Extracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after cancer resection and promoted regrowth of normal mucosa without recurrence of cancer. The present study investigates the mechanisms by which these materials were successful to prevent the cancerous phenotype. ECM downregulated neoplastic esophageal cell function (proliferation, metabolism), but normal esophageal epithelial cells were unaffected in vitro , and suggests a molecular basis (downregulation of PI3K-Akt, cell cycle) for the promising clinical results. The therapeutic effect appeared to be enhanced using homologous esophageal ECM. This study suggests that ECM can be further investigated to treat cancer patients after resection or in combination with targeted therapy. |
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| معلومات مُعتمدة: | F31 CA210694 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: cell/matrix interaction; dynamic reciprocity; esophageal cancer; extracellular matrix bioscaffold; gene expression |
| المشرفين على المادة: | EC 2.7.1.- (Phosphatidylinositol 3-Kinases) EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) |
| تواريخ الأحداث: | Date Created: 20180928 Date Completed: 20190829 Latest Revision: 20200309 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6450457 |
| DOI: | 10.1089/ten.TEA.2018.0105 |
| PMID: | 30259795 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1937-335X |
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| DOI: | 10.1089/ten.TEA.2018.0105 |