دورية أكاديمية
Linear growth following complicated severe malnutrition: 1-year follow-up cohort of Kenyan children.
| العنوان: | Linear growth following complicated severe malnutrition: 1-year follow-up cohort of Kenyan children. |
|---|---|
| المؤلفون: | Ngari MM; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Childhood Acute Illness and Nutrition (CHAIN) Network, Nairobi, Kenya., Iversen PO; Department of Nutrition, IBM, University of Oslo, Oslo, Norway.; Department of Hematology, Oslo University Hospital, Oslo, Norway.; Division of Human Nutrition, Stellenbosch University, Tygerberg, South Africa., Thitiri J; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Childhood Acute Illness and Nutrition (CHAIN) Network, Nairobi, Kenya., Mwalekwa L; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Timbwa M; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Childhood Acute Illness and Nutrition (CHAIN) Network, Nairobi, Kenya., Fegan GW; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Swansea Trials Unit, Swansea University Medical School, Swansea, UK., Berkley JA; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Childhood Acute Illness and Nutrition (CHAIN) Network, Nairobi, Kenya.; Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. |
| المصدر: | Archives of disease in childhood [Arch Dis Child] 2019 Mar; Vol. 104 (3), pp. 229-235. Date of Electronic Publication: 2018 Sep 28. |
| نوع المنشور: | Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BMJ Pub. Group [etc.] Country of Publication: England NLM ID: 0372434 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1468-2044 (Electronic) Linking ISSN: 00039888 NLM ISO Abbreviation: Arch Dis Child Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London :, BMJ Pub. Group [etc.] Original Publication: London : British Medical Association |
| مواضيع طبية MeSH: | Growth Disorders/*etiology , Infant Nutrition Disorders/*complications , Severe Acute Malnutrition/*complications, Body Height/physiology ; Child, Preschool ; Double-Blind Method ; Female ; Follow-Up Studies ; Growth/physiology ; Growth Disorders/epidemiology ; Humans ; Infant ; Infant Nutrition Disorders/epidemiology ; Kenya ; Male ; Severe Acute Malnutrition/epidemiology |
| مستخلص: | Background: Stunting is the most common manifestation of childhood undernutrition worldwide. Children presenting with severe acute malnutrition (SAM) are often also severely stunted. We evaluated linear growth and its determinants after medically complicated SAM. Methods: We performed secondary analysis of clinical trial data ( NCT00934492) from HIV-uninfected Kenyan children aged 2-59 months hospitalised with SAM. Outcome was change in height/length-for-age z-score (HAZ) between enrolment and 12 months later. Exposures were demographic, clinical, anthropometric characteristics and illness episodes during follow-up. Results: Among 1169 children with HAZ values at month 12 (66% of those in original trial), median (IQR) age 11 (7-17) months and mean (SD) HAZ -2.87 (1.6) at enrolment, there was no change in mean HAZ between enrolment and month 12: -0.006Z (95% CI -0.07 to 0.05Z). While 262 (23%) children experienced minimal HAZ change (within ±0.25 HAZ), 472 (40%) lost >0.25 and 435 (37%) gained >0.25 HAZ. After adjusting for regression to the mean, inpatient or outpatient episodes of diarrhoea and inpatient severe pneumonia during follow-up were associated with HAZ loss. Premature birth and not being cared by the biological parent were associated with HAZ gain. Increases in mid-upper arm circumference and weight-for-age were associated with HAZ gain and protected against HAZ loss. Increase in weight-for-height was not associated with HAZ gain but protected against HAZ loss. No threshold of weight gain preceding linear catch-up growth was observed. Conclusions: Interventions to improve dietary quality and prevent illness over a longer period may provide opportunities to improve linear growth. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.) |
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| معلومات مُعتمدة: | United Kingdom Wellcome Trust; MR/M007367/1 United Kingdom MRC_ Medical Research Council; WT083579MA United Kingdom Wellcome Trust |
| فهرسة مساهمة: | Keywords: growth; height; malnutrition; stunting; undernutrition |
| سلسلة جزيئية: | ClinicalTrials.gov NCT00934492 |
| تواريخ الأحداث: | Date Created: 20180930 Date Completed: 20200106 Latest Revision: 20220129 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6556974 |
| DOI: | 10.1136/archdischild-2018-315641 |
| PMID: | 30266874 |
| قاعدة البيانات: | MEDLINE |
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