دورية أكاديمية
IFITM proteins inhibit HIV-1 protein synthesis.
العنوان: | IFITM proteins inhibit HIV-1 protein synthesis. |
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المؤلفون: | Lee WJ; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, United Kingdom., Fu RM; Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom., Liang C; McGill University AIDS Centre, Lady Davis Institute, Montreal, Quebec, H3T 1E2, Canada., Sloan RD; Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 2AT, United Kingdom. richard.sloan@ed.ac.uk.; Division of Infection and Pathway Medicine, School of Biomedical Sciences, University of Edinburgh, Edinburgh, EH16 4SB, United Kingdom. richard.sloan@ed.ac.uk.; ZJU-UoE Institute, Zhejiang University, Haining, Zhejiang, 314400, P.R. China. richard.sloan@ed.ac.uk. |
المصدر: | Scientific reports [Sci Rep] 2018 Sep 28; Vol. 8 (1), pp. 14551. Date of Electronic Publication: 2018 Sep 28. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
مواضيع طبية MeSH: | Antigens, Differentiation/*metabolism , HIV Infections/*metabolism , HIV-1/*physiology , Membrane Proteins/*metabolism , RNA-Binding Proteins/*metabolism , Viral Proteins/*metabolism, HEK293 Cells ; Humans ; Protein Biosynthesis ; Virus Replication |
مستخلص: | Interferon induced transmembrane proteins (IFITMs) inhibit the cellular entry of a broad range of viruses, but it has been suspected that for HIV-1 IFITMs may also inhibit a post-integration replicative step. We show that IFITM expression reduces HIV-1 viral protein synthesis by preferentially excluding viral mRNA transcripts from translation and thereby restricts viral production. Codon-optimization of proviral DNA rescues viral translation, implying that IFITM-mediated restriction requires recognition of viral RNA elements. In addition, we find that expression of the viral accessory protein Nef can help overcome the IFITM-mediated inhibition of virus production. Our studies identify a novel role for IFITMs in inhibiting HIV replication at the level of translation, but show that the effects can be overcome by the lentiviral protein Nef. |
References: | Retrovirology. 2012 Jun 26;9:55. (PMID: 22734835) Nature. 1986 Feb 27-Mar 5;319(6056):727-8. (PMID: 3005869) Retrovirology. 2010 Dec 24;7:115. (PMID: 21184674) Cell. 2015 Oct 22;163(3):774-774.e1. (PMID: 26496613) Virology. 2015 Jan 1;474:10-8. (PMID: 25463599) Nature. 1998 Jan 22;391(6665):397-401. (PMID: 9450757) Annu Rev Virol. 2014 Nov 1;1:261-283. (PMID: 25599080) Cell. 1989 Dec 1;59(5):789-95. (PMID: 2686839) Nat Immunol. 2015 Jun;16(6):546-53. (PMID: 25988886) Nature. 2015 Oct 8;526(7572):218-23. (PMID: 26416733) Nature. 1987 May 7-13;327(6117):20. (PMID: 3646480) J Virol. 2013 Jul;87(14):8110-23. (PMID: 23678185) Virology. 2014 Apr;454-455:11-24. (PMID: 24725927) J Virol. 2001 Jul;75(14):6601-8. (PMID: 11413327) Cell. 2014 Nov 20;159(5):1096-1109. (PMID: 25416948) Proc Natl Acad Sci U S A. 2015 Nov 10;112(45):14030-5. (PMID: 26504241) Hepatology. 2013 Feb;57(2):461-9. (PMID: 22996292) Nature. 2012 Nov 1;491(7422):125-8. (PMID: 23000900) PLoS Pathog. 2011 Jan 06;7(1):e1001258. (PMID: 21253575) J Virol. 2011 Mar;85(6):2828-36. (PMID: 21209113) Cell Host Microbe. 2012 Oct 18;12(4):585-97. (PMID: 23084924) Retrovirology. 2011 Nov 14;8:94. (PMID: 22082156) PLoS Pathog. 2013 Jan;9(1):e1003124. (PMID: 23358889) Cell. 2006 Jun 16;125(6):1055-67. (PMID: 16777597) PLoS One. 2015 Mar 04;10(3):e0118794. (PMID: 25738301) Cell. 2005 Sep 23;122(6):875-86. (PMID: 16179257) J Virol. 2009 Oct;83(20):10527-37. (PMID: 19706714) Proc Natl Acad Sci U S A. 1994 May 24;91(11):4713-7. (PMID: 7515177) Cell Host Microbe. 2015 Oct 14;18(4):409-23. (PMID: 26439863) Science. 2001 Aug 24;293(5534):1503-6. (PMID: 11520990) Nature. 2015 Oct 8;526(7572):212-7. (PMID: 26416734) Cell. 2009 Dec 24;139(7):1243-54. (PMID: 20064371) J Virol. 2000 Dec;74(23):10882-91. (PMID: 11069982) J Biol Chem. 2012 Jun 1;287(23):19631-41. (PMID: 22511783) J Virol. 2014 Dec;88(24):14241-57. (PMID: 25275127) Cell Rep. 2016 Jun 14;15(11):2323-30. (PMID: 27268505) J Virol. 2000 May;74(10):4839-52. (PMID: 10775623) EMBO J. 2012 Nov 5;31(21):4236-46. (PMID: 23023399) J Virol. 2013 Sep;87(17):9923-7. (PMID: 23804635) Nature. 2013 Oct 24;502(7472):559-62. (PMID: 24048477) Virus Genes. 2006 Feb;32(1):105-13. (PMID: 16525741) Virology. 1999 Dec 20;265(2):173-7. (PMID: 10600589) Cell Host Microbe. 2016 Oct 12;20(4):429-442. (PMID: 27640936) PLoS Pathog. 2017 Sep 28;13(9):e1006610. (PMID: 28957419) Microbes Infect. 2013 Apr;15(4):280-90. (PMID: 23376165) J Virol. 2010 Dec;84(23):12185-99. (PMID: 20861257) Nature. 2013 Oct 24;502(7472):563-6. (PMID: 24121441) J Virol. 2017 Mar 13;91(7):. (PMID: 28100616) PLoS Pathog. 2010 Jun 17;6(6):e1000955. (PMID: 20585562) EMBO J. 1997 Dec 15;16(24):7500-10. (PMID: 9405378) Cell Rep. 2015 Oct 6;13(1):145-156. (PMID: 26387945) BMC Cell Biol. 2013 Nov 26;14:52. (PMID: 24279897) Retrovirology. 2011 Dec 06;8:99. (PMID: 22145853) Nature. 2017 Oct 5;550(7674):124-127. (PMID: 28953888) EMBO Rep. 2016 Nov;17(11):1657-1671. (PMID: 27601221) Cell Host Microbe. 2014 Dec 10;16(6):736-47. (PMID: 25464829) Cell Host Microbe. 2013 Apr 17;13(4):452-64. (PMID: 23601107) Virology. 2011 Mar 15;411(2):251-9. (PMID: 21247613) Nat Rev Mol Cell Biol. 2015 Apr;16(4):221-31. (PMID: 25735911) Nature. 2011 Apr 28;472(7344):481-5. (PMID: 21478870) Cell Host Microbe. 2016 Sep 14;20(3):392-405. (PMID: 27631702) J Virol. 2004 Feb;78(4):2006-16. (PMID: 14747565) J Virol. 2011 Mar;85(5):2126-37. (PMID: 21177806) Nat Biotechnol. 2003 May;21(5):569-72. (PMID: 12679787) J Virol. 2012 Dec;86(24):13697-707. (PMID: 23055554) Retrovirology. 2014 Nov 25;11:103. (PMID: 25422070) Cold Spring Harb Perspect Med. 2012 May;2(5):a006940. (PMID: 22553496) Cell Host Microbe. 2009 Jul 23;6(1):54-67. (PMID: 19501037) J Virol. 1998 Mar;72(3):2208-12. (PMID: 9499078) Nat Med. 1996 Mar;2(3):338-42. (PMID: 8612235) Science. 2002 Sep 6;297(5587):1703-6. (PMID: 12215647) PLoS Genet. 2015 May 22;11(5):e1005252. (PMID: 26001115) |
معلومات مُعتمدة: | United Kingdom WT_ Wellcome Trust |
المشرفين على المادة: | 0 (Antigens, Differentiation) 0 (IFITM2 protein, human) 0 (IFITM3 protein, human) 0 (Membrane Proteins) 0 (RNA-Binding Proteins) 0 (Viral Proteins) 0 (leu-13 antigen) |
تواريخ الأحداث: | Date Created: 20180930 Date Completed: 20191111 Latest Revision: 20240211 |
رمز التحديث: | 20240211 |
مُعرف محوري في PubMed: | PMC6162285 |
DOI: | 10.1038/s41598-018-32785-5 |
PMID: | 30266929 |
قاعدة البيانات: | MEDLINE |
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