دورية أكاديمية
The Effect of Autoantibody against M2-Muscarinic Acetylcholine Receptor in Heart Failure Patients on Digoxin Treatment.
| العنوان: | The Effect of Autoantibody against M2-Muscarinic Acetylcholine Receptor in Heart Failure Patients on Digoxin Treatment. |
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| المؤلفون: | Hou D; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, Chinahdy123919@163.com., Fan Z; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.; Department of Cardiology, The First Affiliated Hospital of Xinxiang Medical University, Henan, China., Xu L; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Wang H; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Zhang Z; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Ma G; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Xu X; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Wang X; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Zhang J; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Liu J; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China., Zhang L; Heart Center, Beijing Key Laboratory of Hypertension Research, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China. |
| المصدر: | Cardiology [Cardiology] 2018; Vol. 141 (1), pp. 9-17. Date of Electronic Publication: 2018 Oct 05. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 1266406 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9751 (Electronic) Linking ISSN: 00086312 NLM ISO Abbreviation: Cardiology Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, New York, Karger. |
| مواضيع طبية MeSH: | Cardiotonic Agents/*blood , Digoxin/*blood , Receptor, Muscarinic M2/*blood , Ventricular Function, Left/*drug effects, Adolescent ; Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Autoantibodies ; Biomarkers/blood ; Cardiotonic Agents/therapeutic use ; China ; Digoxin/therapeutic use ; Enzyme-Linked Immunosorbent Assay ; Exercise Test ; Female ; Heart Failure ; Humans ; Male ; Middle Aged ; Prospective Studies ; Young Adult |
| مستخلص: | Background: Autoantibody against M2-muscarinic acetylcholine receptor (anti-M2AChR) has a biological effect similar to a vagus agonist. Digoxin has a function of vagus nervous system stimulation. We hypothesized that anti-M2AChR is highly correlated with digoxin in patients with chronic heart failure (CHF). Methods: Synthetic M2AChR peptides served as the target antigen in an ELISA were used to screen the sera of 80 CHF patients, who were separated into a negative (-) or positive (+) anti-M2AChR group according to their anti-M2AChR reactivity. Echocardiography and serum digoxin concentration (SDC) were performed at baseline and after 1 year of digoxin in combination with the standard treatment regime. The end-point events were compared over 1 year of follow-up. Results: Seventy-two CHF patients completed the final data analysis, including 32 (+)anti-M2AChR and 40 (-)anti-M2AChR patients. The resting heart rate of the positive group was higher than that of the negative group at baseline (p < 0.05; 89.0 ± 1.6 vs. 83.8 ± 1.1 bpm). Both groups showed improvement in the left ventricular end-diastolic and end-systolic dimensions and ejection fraction with digoxin in combination with the standard treatment regime for 1 year (all p < 0.01). However, the 32 patients with (-)anti-M2AChR had greater improvements than the 40 patients with (+)anti-M2AChR, and this was accompanied by a marked decrease of rehospitalization (all p < 0.01) but not of cardiovascular mortality after 1 year. The SDC of patients with (-)anti-M2AChR was significantly lower than that of patients with (+)anti-M2AChR (p < 0.05; 0.63 ± 0.05 vs.1.16 ± 0.06 ng/mL) and had a positive correlation with anti-M2AChR (r = 0.81, p < 0.001). Conclusion: These results suggested that anti-M2AChR could be a useful biomarker of vagus nerve overactivation and is associated with a poor response to digoxin treatment in CHF patients. (© 2018 S. Karger AG, Basel.) |
| فهرسة مساهمة: | Keywords: Rehospitalization; Serum digoxin concentration; Vagus system |
| المشرفين على المادة: | 0 (Autoantibodies) 0 (Biomarkers) 0 (Cardiotonic Agents) 0 (Receptor, Muscarinic M2) 73K4184T59 (Digoxin) |
| تواريخ الأحداث: | Date Created: 20181008 Date Completed: 20191126 Latest Revision: 20191126 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1159/000492527 |
| PMID: | 30293082 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1421-9751 |
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| DOI: | 10.1159/000492527 |