دورية أكاديمية
أعرض في EDS

Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation.

التفاصيل البيبلوغرافية
العنوان: Pelvic radiotherapy for cervical cancer affects importantly the reproducibility of cytological alterations evaluation.
المؤلفون: Lucena FA; Faculty of Health Science of Barretos Dr. Paulo Prata, Avenida Loja Maçônica Renovadora 68, Nº 100, Barretos, 14785-002 São Paulo Brazil., Costa RFA; Faculty of Health Science of Barretos Dr. Paulo Prata, Avenida Loja Maçônica Renovadora 68, Nº 100, Barretos, 14785-002 São Paulo Brazil., Stein MD; 2Department of Pathology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil., Andrade CEMC; 3Department of Gynecologic Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil., Cintra GF; 3Department of Gynecologic Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil., Vieira MA; 3Department of Gynecologic Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil., Dufloth RM; 4Post-Graduation Program in Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil., Fregnani JHTG; 4Post-Graduation Program in Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil., Dos Reis R; 3Department of Gynecologic Oncology, Barretos Cancer Hospital, Rua Antenor Duarte Villela, 1331 - Dr. Paulo Prata, Barretos, 14784-400 São Paulo Brazil.
المصدر: BMC clinical pathology [BMC Clin Pathol] 2018 Oct 05; Vol. 18, pp. 11. Date of Electronic Publication: 2018 Oct 05 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088665 Publication Model: eCollection Cited Medium: Print ISSN: 1472-6890 (Print) Linking ISSN: 14726890 NLM ISO Abbreviation: BMC Clin Pathol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central, [2001]-[2019]
مستخلص: Background: to evaluate the intraobserver and interobserver reproducibility of cervical cytopathology according to previous knowledge of whether patients received radiotherapy (RT) treatment or not.
Methods: The study analyzed a sample of 95 cervix cytological slides; 24 with cytological abnormalities (CA) and presence of RT; 21 without CA and presence of RT; 25 without CA and without previous RT; 25 with CA and without previous RT. Two cytopathology (CP) evaluations of the slides were carried out. For the first CP re-evaluation, the cytotechnologist was blinded for the information of previous RT. For the second CP re-evaluation, the cytotechnologist was informed about previous RT. The results were analyzed through inter and intraobserver agreement using the unweighted and weighted kappa.
Results: Post radiotherapy effects were identified in 44.4% of cases that undergone previous pelvic RT. The agreement for RT status was 66.32% (unweighted K = 0.31, 95%CI: 0.13; 0.49, moderate agreement). The intraobserver agreement, regarding the cytological diagnoses, regardless of radiotherapy status, was 80.32% (weighted K = 0.52, 95%CI: 0.34; 0.68). In no RT group, the intraobserver agreement was 70% (weighted K = 0.47, 95%CI: 0.27;0.65) and in patients that received RT, the intraobserver agreement was 84.09% (unweighted K = 0.37, 95%CI: 0.01;0.74). The interobserver agreement between cytopathology result (abnormal or normal) in the group with RT, considering normal and abnormal CP diagnosis was 14.0% and 12.5%, respectively. There was no association between the cytological alterations and the median time between the end of RT and the cytological diagnosis.
Conclusion: This study showed that RT has an important impact in CP diagnosis because the agreement, also in interobserver and intraobserver analysis, had high discrepancy in patients that received RT. Also, demonstrated that it is difficult to recognize the presence of RT in cytological slides when this information is not provided.
Competing Interests: The study was approved by the Research Ethics Committee of Barretos Cancer Hospital (BCH, Brazil) and the committee’s reference number is 001/2013 of National Commission of Ethics in Research, National Health Council, Ministry of Health (Conep / CNS / MS). This work did not include live subjects and also it was not necessary informed consent due to the design of the study.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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فهرسة مساهمة: Keywords: Cervical cancer; Cervical cytology; Pelvic radiotherapy; Post radiotherapy cells changes; Reproducibility
تواريخ الأحداث: Date Created: 20181017 Latest Revision: 20220321
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC6173841
DOI: 10.1186/s12907-018-0078-z
PMID: 30323716
قاعدة البيانات: MEDLINE
الوصف
تدمد:1472-6890
DOI:10.1186/s12907-018-0078-z