دورية أكاديمية
The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma.
| العنوان: | The close relationship between heparanase and epithelial mesenchymal transition in gastric signet-ring cell adenocarcinoma. |
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| المؤلفون: | Shah S; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France.; Present address: Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan., Fourgeaud C; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Derieux S; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Mirshahi S; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Contant G; Diagnostica Stago, Gennevilliers 92230, France., Pimpie C; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Lo Dico R; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Soria J; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Pocard M; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France., Mirshahi M; Lariboisière Hospital, INSERM U965, Sorbonne University Paris Cité -Paris 7, 75010 Paris, France. |
| المصدر: | Oncotarget [Oncotarget] 2018 Sep 18; Vol. 9 (73), pp. 33778-33787. Date of Electronic Publication: 2018 Sep 18 (Print Publication: 2018). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, N.Y. : Impact Journals |
| مستخلص: | Heparanase (HPSE), a heparan sulfate-specific endo-β-D-glucuronidase, plays an important role in tumor cell metastasis through the degradation of extracellular matrix heparan sulfate proteoglycans. Suramin, a polysulfonated naphthylurea, is an inhibitor of HPSE with suramin analogues. Our objective was to analyze the HPSE involvement in gastric signet ring cell adenocarcinoma (SRCA) invasion. High expression of HPSE mRNA and protein was found in the tumor and in ascites of SRCA as well as in KATO-III cell line. Beside of collagen-I, growth factors (TGF-β1 and VEGF-A, except FGF-2) and epithelial mesenchymal transition (EMT) markers (Snail, Slug, Vimentin, α-SMA and Fibronectin, except E-cadherin) were found higher in main nodules of SRCA as compared to peritumoral sites. Among MDR proteins, MDR-1 and LRP (lung resistance protein) were highly expressed in tumor cells. The formation of 3D cell spheroids was found to be correlated with their origin (adherent or non-adherent KATO-III). After treatment of KATO-III cells with a HPSE inhibitor (suramin), cell proliferation and EMT-related markers, besides collagen-1 expression, were down regulated. In conclusion, in SRCA, HPSE via an autocrine secretion is involved in acquisition of mesenchymal phenotype and tumor cell malignancy. Therefore, HPSE could be an interesting pharmacological target for the treatment of SRCA. Competing Interests: CONFLICTS OF INTEREST The authors have no financial conflicts of interest. |
| References: | J Biol Chem. 2008 Feb 15;283(7):4165-76. (PMID: 18073203) Annu Rev Cell Dev Biol. 2011;27:347-76. (PMID: 21740232) Oncol Res Treat. 2014;37(10):584-9. (PMID: 25342509) Cancer Metastasis Rev. 1996 Jun;15(2):177-86. (PMID: 8842489) Genes Cells. 2005 Feb;10(2):97-106. (PMID: 15676021) Nat Cell Biol. 2001 Sep;3(9):778-84. (PMID: 11533656) J Cell Biochem. 1988 Feb;36(2):157-67. (PMID: 3281960) J Biol Chem. 1995 May 12;270(19):11322-6. (PMID: 7744769) Cell. 2009 Nov 25;139(5):871-90. (PMID: 19945376) J Clin Invest. 2009 Jun;119(6):1420-8. (PMID: 19487818) Trends Biochem Sci. 2009 Oct;34(10):511-9. (PMID: 19733083) J Korean Med Sci. 2006 Apr;21(2):253-8. (PMID: 16614510) Genes Dev. 2003 May 15;17(10):1253-70. (PMID: 12756227) J Biol Chem. 1991 May 25;266(15):9661-6. (PMID: 2033058) EMBO J. 1997 Apr 1;16(7):1695-709. (PMID: 9130714) Stem Cells. 2011 Jul;29(7):1102-11. (PMID: 21608080) Cell. 2011 Mar 4;144(5):646-74. (PMID: 21376230) Cancer Prev Res (Phila). 2010 Mar;3(3):348-58. (PMID: 20179298) Eur J Surg Oncol. 2010 Dec;36(12):1131-8. (PMID: 20933363) FASEB J. 2003 Jun;17(9):1015-25. (PMID: 12773484) Cancer Chemother Pharmacol. 2010 Nov;66(6):1019-29. (PMID: 20107799) Thromb Res. 2014 May;133 Suppl 2:S90-4. (PMID: 24862152) EMBO J. 1999 Jan 4;18(1):188-97. (PMID: 9878062) Eur J Med Chem. 2017 Jan 5;125:793-794. (PMID: 27741490) World J Gastroenterol. 2012 Sep 7;18(33):4610-7. (PMID: 22969237) Biochim Biophys Acta. 2014 Sep;1843(9):2122-8. (PMID: 24937189) J Biol Chem. 2012 Jun 29;287(27):22450-62. (PMID: 22613725) Cancer Res. 2003 Sep 15;63(18):5821-8. (PMID: 14522905) Exp Oncol. 2014 Sep;36(3):144-56. (PMID: 25265346) Nature. 2009 Apr 23;458(7241):1056-60. (PMID: 19262508) Cancer Res. 2001 Jun 15;61(12):4655-9. (PMID: 11406531) Parasit Vectors. 2010 Mar 10;3(1):15. (PMID: 20219092) Oncotarget. 2016 May 3;7(18):25315-27. (PMID: 27015365) Acta Pharmacol Sin. 2018 Aug;39(8):1326-1337. (PMID: 29417941) Trends Biochem Sci. 1991 Jul;16(7):268-71. (PMID: 1926336) Oncotarget. 2014 May 30;5(10):2881-911. (PMID: 24931005) Am J Surg. 2004 Sep;188(3):327-32. (PMID: 15450843) Cancer Chemother Pharmacol. 2012 Jul;70(1):49-56. (PMID: 22729159) Int J Cancer. 2003 Mar 20;104(2):167-74. (PMID: 12569571) Biomol Concepts. 2015 Dec;6(5-6):415-21. (PMID: 26552066) Cancer Cell Int. 2015 May 13;15:52. (PMID: 26052253) J Biol Chem. 2012 Jan 6;287(2):1478-88. (PMID: 22102278) Biomed Res Int. 2015;2015:538019. (PMID: 25866791) Neoplasia. 2006 Jul;8(7):596-606. (PMID: 16867222) PLoS One. 2015 Feb 06;10(2):e0116888. (PMID: 25658916) |
| فهرسة مساهمة: | Keywords: KATO-III cell line; carcinomatosis; epithelial mesenchymal transition; heparanase; signet ring cell adenocarcinoma |
| تواريخ الأحداث: | Date Created: 20181019 Latest Revision: 20191120 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6173471 |
| DOI: | 10.18632/oncotarget.26042 |
| PMID: | 30333909 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1949-2553 |
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| DOI: | 10.18632/oncotarget.26042 |