دورية أكاديمية
Multilocus sequence typing of Cryptococcus neoformans var. grubii from Laos in a regional and global context.
| العنوان: | Multilocus sequence typing of Cryptococcus neoformans var. grubii from Laos in a regional and global context. |
|---|---|
| المؤلفون: | Thanh LT; Oxford University Clinical Research Unit, Vietnam., Phan TH; Oxford University Clinical Research Unit, Vietnam., Rattanavong S; Laos-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Lao People's Democratic Republic., Nguyen TM; Oxford University Clinical Research Unit, Vietnam., Duong AV; Oxford University Clinical Research Unit, Vietnam., Dacon C; Sir William Dunn School of Pathology, University of Oxford, UK., Hoang TN; Oxford University Clinical Research Unit, Vietnam., Nguyen LPH; Oxford University Clinical Research Unit, Vietnam.; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Tran CTH; Oxford University Clinical Research Unit, Vietnam., Davong V; Laos-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Lao People's Democratic Republic., Nguyen CVV; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam., Thwaites GE; Oxford University Clinical Research Unit, Vietnam.; Nuffield Department of Medicine, Oxford University, UK., Boni MF; Nuffield Department of Medicine, Oxford University, UK.; Department of Biology, Pennsylvania State University, USA., Dance D; Laos-Oxford-Mahosot Hospital Wellcome Trust Research Unit, Lao People's Democratic Republic.; Nuffield Department of Medicine, Oxford University, UK.; Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK., Ashton PM; Oxford University Clinical Research Unit, Vietnam., Day JN; Oxford University Clinical Research Unit, Vietnam.; Nuffield Department of Medicine, Oxford University, UK. |
| المصدر: | Medical mycology [Med Mycol] 2019 Jul 01; Vol. 57 (5), pp. 557-565. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: PubMed not MEDLINE; MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Oxford : Oxford University Press Original Publication: Oxford : Blackwell Science, c1998- |
| مستخلص: | Cryptococcosis causes approximately 180 000 deaths each year in patients with human immunodeficiency virus (HIV). Patients with other forms of immunosuppression are also at risk, and disease is increasingly recognized in apparently immunocompetent individuals. Cryptococcus neoformans var. grubii, responsible for the majority of cases, is distributed globally. We used the consensus ISHAM Multilocus sequence typing (MLST) scheme to define the population structure of clinical C. neoformans var. grubii isolates from Laos (n = 81), which we placed into the global context using published MLST data from other countries (total N = 1047), including a reanalysis of 136 Vietnamese isolates previously reported. We observed a phylogeographical relationship in which the Laotian population was similar to its neighbor Thailand, being dominated (83%) by Sequence Types (ST) 4 and 6. This phylogeographical structure changed moving eastwards, with Vietnam's population consisting of an admixture of isolates dominated by the ST4/ST6 (35%) and ST5 (48%) lineages. The ST5 lineage is the predominant ST reported from China and East Asia, where it accounts for >90% of isolates. Analysis of genetic distance (Fst) between different populations of C. neoformans var. grubii supports this intermediate structure of the Vietnamese population. The pathogen and host diversity reported from Vietnam provide the strongest epidemiological evidence of the association between ST5 and HIV-uninfected patients. Regional anthropological genetic distances suggest diversity in the C. neoformans var. grubii population across Southeast Asia is driven by ecological rather than human host factors. Where the ST5 lineage is present, disease in HIV-uninfected patients is to be expected. (© The Author(s) 2018. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.) |
| معلومات مُعتمدة: | United Kingdom Wellcome Trust; G1100684 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Cryptococcus neoformans ; Laos; Vietnam; multilocus sequence typing; population structure |
| تواريخ الأحداث: | Date Created: 20181020 Latest Revision: 20231212 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6581559 |
| DOI: | 10.1093/mmy/myy105 |
| PMID: | 30339200 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher كن أول من يترك تعليقا!