دورية أكاديمية
أعرض في EDS

Antifungal potential of punicalagin against Cryptococcus neoformans species complex.

التفاصيل البيبلوغرافية
العنوان: Antifungal potential of punicalagin against Cryptococcus neoformans species complex.
المؤلفون: Silva TC; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás, Brazil., Zara ALSA; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás, Brazil., Sá FADS; Universidade Federal de Goiás, Faculdade de Farmácia, Goiânia, Goiás, Brazil., Bara MTF; Universidade Federal de Goiás, Faculdade de Farmácia, Goiânia, Goiás, Brazil., Ávila RI; Universidade Federal de Goiás, Faculdade de Farmácia, Goiânia, Goiás, Brazil., Costa CR; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás, Brazil., Valadares MC; Universidade Federal de Goiás, Faculdade de Farmácia, Goiânia, Goiás, Brazil., Santos ASD; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás, Brazil., Freitas VAQ; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás, Brazil., Silva MDRR; Universidade Federal de Goiás, Instituto de Patologia Tropical e Saúde Pública, Goiânia, Goiás, Brazil.
المصدر: Revista do Instituto de Medicina Tropical de Sao Paulo [Rev Inst Med Trop Sao Paulo] 2018 Oct 22; Vol. 60, pp. e60. Date of Electronic Publication: 2018 Oct 22.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo Country of Publication: Brazil NLM ID: 7507484 Publication Model: Electronic Cited Medium: Internet ISSN: 1678-9946 (Electronic) Linking ISSN: 00364665 NLM ISO Abbreviation: Rev Inst Med Trop Sao Paulo Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Sao Paulo : Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo
مواضيع طبية MeSH: Antifungal Agents/*pharmacology , Cryptococcus neoformans/*drug effects , Hydrolyzable Tannins/*pharmacology , Lythraceae/*chemistry , Plant Leaves/*chemistry, Animals ; Cryptococcus neoformans/isolation & purification ; Cytotoxicity Tests, Immunologic ; Microbial Sensitivity Tests
مستخلص: This study evaluated the antifungal activity and cytotoxicity profile of the ellagitannin punicalagin, a compound extracted from the L. pacari A. St.-Hil (Lythraceae) leaf, against Cryptococcus neoformans species complex. Minimum inhibitory concentrations (MIC) were checked using the broth microdilution method. Minimum fungicidal concentrations (MFC) and time of death were used to confirm the antifungal activity of the compound. The in vitro cytotoxicity of punicalagin was tested in BALB/c3T3 fibroblasts and A549 human lung cancer cell line, while the hemolytic potential was tested on sheep erythrocytes. The morphological changes induced in yeast strains by the presence of punicalagin were also analyzed. Tested on eight isolates of the C. neoformans complex punicalagin showed MIC of 0.5 to 4.0 μg/mL and MFC> 256 μg/mL. Punicalagin also demonstrated a good growth inhibitory activity in time-kill curves, but it was not able to achieve a statistically significant reduction of fungal growth suggesting a fungistatic effect of the compound. In vitro cytotoxicity studies using the two cell lines showed that punicalagin has low activity on these cells and no activity on sheep erythrocytes. Morphological changes were seen in the yeasts strains studied when treated with punicalagin. Therefore, punicalagin is a potential antifungal for important pathogenic yeasts and presents a low cytotoxicity profile associated with no hemolytic effects.
References: Braz J Microbiol. 2013 Dec 17;44(3):839-48. (PMID: 24516425)
BMC Complement Altern Med. 2016 Jun 02;16:162. (PMID: 27251466)
Fitoterapia. 2009 Sep;80(6):369-73. (PMID: 19446614)
Clin Infect Dis. 2000 Apr;30(4):710-8. (PMID: 10770733)
Diagn Microbiol Infect Dis. 2012 Apr;72(4):332-9. (PMID: 22341512)
J Immunol Methods. 1983 Dec 16;65(1-2):55-63. (PMID: 6606682)
Mycopathologia. 2007 Mar;163(3):137-43. (PMID: 17356790)
J Fungi (Basel). 2016 Oct 02;2(4):. (PMID: 29376943)
Toxicol Appl Pharmacol. 2016 Nov 1;310:1-8. (PMID: 27546523)
J Ethnopharmacol. 1999 Sep;66(3):335-8. (PMID: 10473181)
Antimicrob Agents Chemother. 1997 Jun;41(6):1392-5. (PMID: 9174207)
Res Microbiol. 2010 Sep;161(7):534-40. (PMID: 20541606)
Front Med (Lausanne). 2016 Mar 15;3:11. (PMID: 27014694)
Infect Dis Clin North Am. 2016 Mar;30(1):179-206. (PMID: 26897067)
AIDS. 2009 Feb 20;23(4):525-30. (PMID: 19182676)
Ann Clin Microbiol Antimicrob. 2014 Sep 05;13:32. (PMID: 25260038)
J Ethnopharmacol. 2000 Sep;72(1-2):173-8. (PMID: 10967469)
Planta Med. 2007 May;73(5):461-7. (PMID: 17566148)
Antimicrob Agents Chemother. 2010 Dec;54(12):5139-45. (PMID: 20855729)
J Microbiol Methods. 2006 Mar;64(3):416-9. (PMID: 16054253)
Curr Pharm Biotechnol. 2016;17(4):365-75. (PMID: 26696018)
Clin Infect Dis. 2012 Sep;55(6):789-98. (PMID: 22670042)
المشرفين على المادة: 0 (Antifungal Agents)
0 (Hydrolyzable Tannins)
65995-63-3 (punicalagin)
تواريخ الأحداث: Date Created: 20181027 Date Completed: 20190206 Latest Revision: 20230928
رمز التحديث: 20230928
مُعرف محوري في PubMed: PMC6199124
DOI: 10.1590/S1678-9946201860060
PMID: 30365643
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-9946
DOI:10.1590/S1678-9946201860060