دورية أكاديمية
Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients.
| العنوان: | Prognostic Importance of Tumor Deposits in the Ipsilateral Axillary Region of Breast Cancer Patients. |
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| المؤلفون: | Durak MG; Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey. merihguray@yahoo.com., Canda T; Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey., Yilmaz B; Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey., Seker NS; Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey., Kokkoz SE; Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey., Alicikus ZA; Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey., Akturk N; Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey., Gorken IB; Department of Radiation Oncology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey., Ellidokuz H; Department of Preventive Oncology, Dokuz Eylul University Institute of Oncology, Izmir, Turkey., Sevinc AI; Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey., Saydam S; Department of General Surgery, Dokuz Eylul University Faculty of Medicine, Izmir, Turkey., Sarioglu S; Department of Pathology, Dokuz Eylul University Faculty of Medicine, Inciralti, 35340, Izmir, Turkey. |
| المصدر: | Pathology oncology research : POR [Pathol Oncol Res] 2019 Apr; Vol. 25 (2), pp. 577-583. Date of Electronic Publication: 2018 Oct 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Media S. A Country of Publication: Switzerland NLM ID: 9706087 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2807 (Electronic) Linking ISSN: 12194956 NLM ISO Abbreviation: Pathol Oncol Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : Lausanne, Switzerland : Frontiers Media S. A. Original Publication: Budapest, Hungary : Science Press, c1995- |
| مواضيع طبية MeSH: | Breast Neoplasms/*pathology , Neoplasm Metastasis/*pathology, Adipose Tissue/pathology ; Adult ; Aged ; Aged, 80 and over ; Axilla ; Breast Neoplasms/mortality ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Middle Aged ; Neoplasm Staging ; Prognosis |
| مستخلص: | Tumor deposits (TD) are irregular discrete tumor masses in adipose tissue, discontinuous from the primary tumor, that are described in various cancers. The incidence and/or prognostic value of TD in breast carcinomas have not been studied so far. We reevaluated 145 breast cancer patients, diagnosed and treated between 2001 and 2006 at our institution for the presence and incidence of TD. Histologic type, grade, size of the primary tumor, estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 status of the tumor, and presence of peritumoral lymphovascular invasion were included in the data. TD were detected in 42 cases (29.0%). The mean age of the patients was 52.2 years (27-82). Most patients (79.3%) had either invasive carcinoma of no special type (NST) or invasive lobular carcinoma, and most tumors (86.9%) were either grade 2 or 3. After excluding TD from the number of metastatic lymph nodes, the pN status of 9 patients changed. Univariate analysis of 110 patients with follow-up information revealed that the new pN status (p = 0.036), presence of local recurrence (p = 0.016) and TD (p = 0.003) were significantly correlated with distant metastases. The median follow-up of the patients was 84 months (5-161), 10-year disease-free survival and overall survival were 67.2% and 73.7%, respectively. In multivariate analysis, presence of TD remained independently associated with distant metastasis (p = 0.002). The probability of distant metastasis was 3.3 times higher in patients with TD. These results emphasize that TD are present in breast cancer patients, and that their presence should warn the clinician in terms of possible distant metastasis. Therefore, presence of TD, the evaluation of which is neither time consuming nor require sophisticated methods, should be included in pathology reports. |
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| فهرسة مساهمة: | Keywords: Axillary dissection; Breast cancer; Prognosis; Tumor deposits |
| تواريخ الأحداث: | Date Created: 20181029 Date Completed: 20190610 Latest Revision: 20240702 |
| رمز التحديث: | 20240702 |
| DOI: | 10.1007/s12253-018-0515-4 |
| PMID: | 30368727 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1532-2807 |
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| DOI: | 10.1007/s12253-018-0515-4 |