دورية أكاديمية
أعرض في EDS

Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds ( Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia.

التفاصيل البيبلوغرافية
العنوان: Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds ( Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia.
المؤلفون: Reis MÁ; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Novaes RD; Departamento de Biologia Estrutural, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Baggio SR; Centro de Ciência e Qualidade de Alimentos, Instituto de Tecnologia de Alimentos (ITAL), Campinas, São Paulo, Brazil., Viana ALM; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Salles BCC; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Duarte SMDS; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Rodrigues MR; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil., Paula FBA; Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Universidade Federal de Alfenas (UNIFAL-MG), Alfenas, Minas Gerais, Brazil.
المصدر: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2018 Oct 02; Vol. 2018, pp. 8376081. Date of Electronic Publication: 2018 Oct 02 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub Country of Publication: United States NLM ID: 101215021 Publication Model: eCollection Cited Medium: Print ISSN: 1741-427X (Print) Linking ISSN: 1741427X NLM ISO Abbreviation: Evid Based Complement Alternat Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2011- : New York, NY : Hindawi Pub.
Original Publication: Oxford, UK : Oxford University Press, c2004-
مستخلص: The oil obtained from baru ( Dipteryx alata Vog.) almonds exhibits high energy value and is reported in popular medicine for the treatment of rheumatic diseases and reproductive disturbances. Although baru oil is used in domestic cuisine, the chemical characterization of this oil and its effects on lipid metabolism are still poorly understood. Therefore, this study evaluated the fatty acid (FA) profile and the effects of baru oil on liver and aorta in a murine model of dyslipidemia. The chromatographic profile of baru oil showed high levels of unsaturated FAs, especially oleic acid. Saturated FAs, such as palmitic and lignoceric acids, were found in lower amounts. Hypercholesterolemia was induced in male Wistar rats by daily administration of a lipid emulsion by gavage for 15 weeks. Biochemical and histopathological analysis were performed on serum, aorta, and liver. The results demonstrated that animals developed marked hypercholesterolemia, liver steatosis, and increased lipid peroxidation in the aorta. Treatment with baru oil attenuated lipid peroxidation and drastically reduced liver damage, especially ballooning degeneration and steatosis. By restricting vascular and hepatic injury, this oil showed potential applicability as a functional food, reinforcing its use in popular medicine and domestic cuisine.
References: Metabolism. 2016 Aug;65(8):1049-61. (PMID: 26997538)
Clin Chim Acta. 2014 Sep 25;436:332-47. (PMID: 24933428)
J Hepatol. 2013 May;58(5):984-92. (PMID: 23333450)
Clin Biochem. 2010 Oct;43(15):1220-4. (PMID: 20691171)
Prog Lipid Res. 2013 Jan;52(1):175-91. (PMID: 23206728)
Annu Rev Public Health. 2008;29:253-72. (PMID: 18031223)
Plant Foods Hum Nutr. 2015 Mar;70(1):50-5. (PMID: 25577329)
Metabolism. 2016 Aug;65(8):1109-23. (PMID: 27237577)
Arq Bras Cardiol. 2013 Oct;101(4 Suppl 1):1-20. (PMID: 24217493)
JPEN J Parenter Enteral Nutr. 2014 Jul;38(5):608-16. (PMID: 23757305)
Oxid Med Cell Longev. 2016;2016:8173876. (PMID: 27418954)
J Hepatol. 2013 Apr;58(4):801-10. (PMID: 23183522)
Nutr Metab Cardiovasc Dis. 2014 Dec;24(12):1330-6. (PMID: 25149894)
Acta Cir Bras. 2005 Jan-Feb;20(1):93-9. (PMID: 15810470)
Biochim Biophys Acta. 2016 Oct;1861(10):1513-24. (PMID: 26924249)
Heart Fail Clin. 2012 Oct;8(4):589-607. (PMID: 22999242)
Arq Bras Cardiol. 2001 Nov;77 Suppl 3:1-48. (PMID: 11781591)
Prog Lipid Res. 2014 Jul;55:17-29. (PMID: 24794260)
Nutr Res. 2014 Jun;34(6):535-43. (PMID: 25026921)
Hepatology. 2006 Feb;43(2 Suppl 1):S99-S112. (PMID: 16447287)
Gastroenterol Res Pract. 2016;2016:7109270. (PMID: 27006654)
Circulation. 2014 Jan 21;129(3):399-410. (PMID: 24446411)
Int J Exp Pathol. 2016 Apr;97(2):114-24. (PMID: 27277193)
Nutr Res. 2016 Jul;36(7):710-8. (PMID: 27262537)
J Ethnopharmacol. 2011 May 17;135(2):469-75. (PMID: 21453765)
BMC Med. 2013 Jul 16;11:164. (PMID: 23866098)
Am J Clin Nutr. 2003 Sep;78(3 Suppl):544S-551S. (PMID: 12936948)
Am J Clin Nutr. 2003 May;77(5):1146-55. (PMID: 12716665)
Prostaglandins Leukot Essent Fatty Acids. 2013 Nov-Dec;89(6):391-401. (PMID: 24140006)
Lab Pract. 1973 Jul;22(6):475-6 passim. (PMID: 4727126)
تواريخ الأحداث: Date Created: 20181030 Latest Revision: 20201001
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6189660
DOI: 10.1155/2018/8376081
PMID: 30369957
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-427X
DOI:10.1155/2018/8376081