دورية أكاديمية
Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome.
| العنوان: | Prenatal Androgenization of Ewes as a Model of Hirsutism in Polycystic Ovary Syndrome. |
|---|---|
| المؤلفون: | Tonellotto Dos Santos J; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Escarião da Nóbrega J Jr; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Serrano Mujica LK; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Dos Santos Amaral C; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Machado FA; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Manta MW; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Rizzetti TM; Laboratory of Pesticide Analysis (LARP), Department of Chemistry, Federal University of Santa Maria, Santa Maria, Brazil., Zanella R; Laboratory of Pesticide Analysis (LARP), Department of Chemistry, Federal University of Santa Maria, Santa Maria, Brazil., Fighera R; Department of Pathology, Federal University of Santa Maria, Santa Maria, Brazil., Antoniazzi AQ; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Gonçalves PBD; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil., Comim FV; Laboratory of Biotechnology and Animal Reproduction (BioRep), Federal University of Santa Maria, Santa Maria, Brazil.; Department of Clinical Medicine, Health Science Center, Federal University of Santa Maria, Santa Maria, Brazil. |
| المصدر: | Endocrinology [Endocrinology] 2018 Dec 01; Vol. 159 (12), pp. 4056-4064. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
| مواضيع طبية MeSH: | Androgens* , Disease Models, Animal* , Hirsutism*/blood , Hirsutism*/chemically induced , Hirsutism*/complications , Hirsutism*/pathology , Polycystic Ovary Syndrome*/blood , Polycystic Ovary Syndrome*/complications , Polycystic Ovary Syndrome*/pathology , Sheep*, Prenatal Exposure Delayed Effects/*chemically induced , Virilism/*chemically induced, Animals ; Female ; Glucose Tolerance Test ; Hyperandrogenism/blood ; Hyperandrogenism/chemically induced ; Hyperandrogenism/pathology ; Male ; Pregnancy ; Prenatal Exposure Delayed Effects/blood ; Prenatal Exposure Delayed Effects/pathology ; Testosterone Propionate ; Virilism/blood ; Virilism/pathology |
| مستخلص: | The main clinical feature associated with hyperandrogenism in polycystic ovary syndrome (PCOS) in humans is hirsutism, where hair increases its length, pigmentation, and particularly its diameter. Currently, it is not known whether PCOS animal models also exhibit changes in the hair. Therefore, the aim of this study was to explore the wool characteristics in sheep prenatally androgenized (PA) with testosterone propionate. After 4 and 13 months of life, wool was collected from the top of the shoulder of both females and males (both androgenized and controls). The offspring sheep were followed for up to 19 months of life to evaluate testosterone and androstenedione serum levels by ultra-high-performance liquid chromatography-tandem mass spectrometry, determine insulin and glucose response to intravenous glucose tolerance test, and address estrus cyclicity during the second breeding season. PA male animals showed a reduction in wool fiber diameter at 4 months of age compared with controls (P = 0.02) but not at 13 months, whereas PA females showed increased hair diameter at 13 months (P = 0.002), with no difference at 4 months. No substantial changes in other hair parameters (length, color, and medullation) were identified. In addition, increased levels of serum testosterone were observed in PA female sheep compared with controls at 12 months (P = 0.03). Our results indicate for the first time, to our knowledge, that changes in wool fiber diameter observed in PA ewes replicate, at the translational level, the increase in hair diameter in hirsute women with PCOS. |
| المشرفين على المادة: | 0 (Androgens) WI93Z9138A (Testosterone Propionate) |
| تواريخ الأحداث: | Date Created: 20181031 Date Completed: 20190509 Latest Revision: 20220408 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1210/en.2018-00781 |
| PMID: | 30376052 |
| قاعدة البيانات: | MEDLINE |
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