دورية أكاديمية
Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization.
| العنوان: | Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization. |
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| المؤلفون: | Nikolova AP; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Hitzeman TC; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Baum R; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Caldaruse AM; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Agvanian S; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Xie Y; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California., Geft DR; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Chang DH; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Moriguchi JD; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Hage A; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Azarbal B; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Czer LS; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Kittleson MM; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Patel JK; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Wu AHB; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, California., Kobashigawa JA; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Hamilton M; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California., Hong T; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California., Shaw RM; Division of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.; Division of Cardiology, Department of Medicine, University of California, Los Angeles, Los Angeles, California. |
| المصدر: | JAMA cardiology [JAMA Cardiol] 2018 Dec 01; Vol. 3 (12), pp. 1206-1210. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Medical Association Country of Publication: United States NLM ID: 101676033 Publication Model: Print Cited Medium: Internet ISSN: 2380-6591 (Electronic) NLM ISO Abbreviation: JAMA Cardiol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Chicago, Illinois] : American Medical Association, [2016]- |
| مواضيع طبية MeSH: | Adaptor Proteins, Signal Transducing/*blood , Heart Failure/*diagnosis , Hospitalization/*trends , Nuclear Proteins/*blood , Stroke Volume/*physiology , Tumor Suppressor Proteins/*blood, Biomarkers/blood ; Female ; Follow-Up Studies ; Heart Failure/blood ; Heart Failure/physiopathology ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain/blood ; Peptide Fragments/blood ; Prognosis ; Protein Precursors ; Severity of Illness Index ; Ventricular Function, Left |
| مستخلص: | Importance: Transverse tubule remodeling is a hallmark of heart failure. Cardiac bridging integrator 1 (cBIN1) is a circulating membrane scaffolding protein that is essential for transverse tubule health, and its plasma level declines with disease. Objective: To determine if a cBIN1-derived score can serve as a diagnostic biomarker of heart failure with preserved ejection fraction (HFpEF). Design, Setting, and Participants: In this cohort study, the cBIN1 score (CS) was determined from enzyme-linked immunoabsorbent assay-measured plasma cBIN1 concentrations from study participants in an ambulatory heart failure clinic at Cedars-Sinai Medical Center. Consecutive patients with a confirmed diagnosis of heart failure with preserved ejection fraction (HFpEF; defined by a left ventricular ejection fraction ≥50%) were recruited from July 2014 to November 2015 and compared with age-matched and sex-matched healthy volunteers with no known cardiovascular diagnoses and participants with risk factors for heart failure but no known HFpEF. Baseline characteristics and 1-year longitudinal clinical information were obtained through electronic medical records. Data analysis occurred from November 2016 to November 2017. Main Outcomes and Measures: The analysis examined the ability of the CS and N-terminal pro-B-type natriuretic peptide (NT-proBNP) results to differentiate among patients with HFpEF, healthy control participants, and control participants with risk factors for heart failure. We further explored the association of the CS with future cardiovascular hospitalizations. Results: A total of 52 consecutive patients with a confirmed diagnosis of HFpEF were enrolled (mean [SD] age, 57 [15] years; 33 [63%] male). The CS values are significantly higher in the patients with HFpEF (median [interquartile range (IQR)], 1.85 [1.51-2.28]) than in the 2 control cohorts (healthy control participants: median [IQR], -0.03 [-0.48 to 0.41]; control participants with risk factors only: median [IQR], -0.08 [-0.75 to 0.42]; P < .001). For patients with HFpEF, the CS outperforms NT-proBNP when the comparator group was either healthy control participants (CS: area under curve [AUC], 0.98 [95% CI, 0.96-1.00]; NT-proBNP level: AUC, 0.93 [95% CI, 0.88-0.99]; P < .001) or those with risk factors (CS: AUC, 0.98 [95% CI, 0.97-1.00]; NT-proBNP: AUC, 0.93 [95% CI, 0.88-0.99]; P < .001). Kaplan-Meier analysis of 1-year cardiovascular hospitalizations adjusted for age, sex, body mass index, and NT-proBNP levels reveals that patients with HFpEF with CS greater than or equal to 1.80 have a hazard ratio of 3.8 (95% CI, 1.3-11.2; P = .02) for hospitalizations compared with those with scores less than 1.80. Conclusions and Relevance: If further validated, the plasma CS, a marker of transverse tubule dysfunction, may serve as a biomarker of cardiomyocyte remodeling that has the potential to aide in the diagnosis of HFpEF. |
| التعليقات: | Comment in: JAMA Cardiol. 2018 Dec 1;3(12):1211. (PMID: 30383144) |
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| معلومات مُعتمدة: | R01 HL094414 United States HL NHLBI NIH HHS; R01 HL133286 United States HL NHLBI NIH HHS; R01 HL138577 United States HL NHLBI NIH HHS; T32 HL116273 United States HL NHLBI NIH HHS |
| المشرفين على المادة: | 0 (Adaptor Proteins, Signal Transducing) 0 (BIN1 protein, human) 0 (Biomarkers) 0 (Nuclear Proteins) 0 (Peptide Fragments) 0 (Protein Precursors) 0 (Tumor Suppressor Proteins) 0 (pro-brain natriuretic peptide (1-76)) 114471-18-0 (Natriuretic Peptide, Brain) |
| تواريخ الأحداث: | Date Created: 20181102 Date Completed: 20191003 Latest Revision: 20200309 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6583707 |
| DOI: | 10.1001/jamacardio.2018.3539 |
| PMID: | 30383171 |
| قاعدة البيانات: | MEDLINE |
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