دورية أكاديمية
Polyamine synthesis as a target of MYC oncogenes.
| العنوان: | Polyamine synthesis as a target of MYC oncogenes. |
|---|---|
| المؤلفون: | Bachmann AS; From the Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, Michigan 49503 and andre.bachmann@hc.msu.edu., Geerts D; the Department of Medical Biology, Amsterdam University Medical Center, University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. |
| المصدر: | The Journal of biological chemistry [J Biol Chem] 2018 Nov 30; Vol. 293 (48), pp. 18757-18769. Date of Electronic Publication: 2018 Nov 07. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York, NY] : Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Original Publication: Baltimore, MD : American Society for Biochemistry and Molecular Biology |
| مواضيع طبية MeSH: | Oncogene Protein p55(v-myc)/*metabolism , Ornithine Decarboxylase/*metabolism , Polyamines/*metabolism, Animals ; Humans ; Oncogene Protein p55(v-myc)/genetics ; Ornithine Decarboxylase/genetics |
| مستخلص: | This paper is in recognition of the 100th birthday of Dr. Herbert Tabor, a true pioneer in the polyamine field for over 70 years, who served as the editor-in-chief of the Journal of Biological Chemistry from 1971 to 2010. We review current knowledge of MYC proteins (c-MYC, MYCN, and MYCL) and focus on ornithine decarboxylase 1 ( ODC1 ), an important bona fide gene target of MYC, which encodes the sentinel, rate-limiting enzyme in polyamine biosynthesis. Although notable advances have been made in designing inhibitors against the "undruggable" MYCs, their downstream targets and pathways are currently the main avenue for therapeutic anticancer interventions. To this end, the MYC-ODC axis presents an attractive target for managing cancers such as neuroblastoma, a pediatric malignancy in which MYCN gene amplification correlates with poor prognosis and high-risk disease. ODC and polyamine levels are often up-regulated and contribute to tumor hyperproliferation, especially of MYC-driven cancers. We therefore had proposed to repurpose α-difluoromethylornithine (DFMO), an FDA-approved, orally available ODC inhibitor, for management of neuroblastoma, and this intervention is now being pursued in several clinical trials. We discuss the regulation of ODC and polyamines, which besides their well-known interactions with DNA and tRNA/rRNA, are involved in regulating RNA transcription and translation, ribosome function, proteasomal degradation, the circadian clock, and immunity, events that are also controlled by MYC proteins. (© 2018 Bachmann and Geerts.) |
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| فهرسة مساهمة: | Keywords: DFMO; MYC; Myc (c-Myc); Neuroblastoma clinical trials; ODC; cancer; circadian clock; glycolysis; neuroblastoma; polyamine; polyamines; proteasome; translation; translation initiation factor |
| المشرفين على المادة: | 0 (Oncogene Protein p55(v-myc)) 0 (Polyamines) EC 4.1.1.17 (Ornithine Decarboxylase) |
| تواريخ الأحداث: | Date Created: 20181109 Date Completed: 20190617 Latest Revision: 20210205 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6290138 |
| DOI: | 10.1074/jbc.TM118.003336 |
| PMID: | 30404920 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1083-351X |
|---|---|
| DOI: | 10.1074/jbc.TM118.003336 |