دورية أكاديمية
Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection.
| العنوان: | Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection. |
|---|---|
| المؤلفون: | da Rocha ICM; Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Secretaria Municipal de Saúde de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil., Dos Santos LHM; Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Coura-Vital W; Departamento de Análises Clínicas, Pós-graduação em Ciências Farmacêuticas, Escola de Farmácia, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.; Pós-graduação em Ciências Biológicas, Núcleo de Pesquisa em Ciências Biológicas, Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil., da Cunha GMR; Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Magalhães FDC; Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., da Silva TAM; Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.; Instituto de Ensino e Pesquisa da Santa Casa Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil., Morais MHF; Secretaria Municipal de Saúde de Belo Horizonte, Belo Horizonte, Minas Gerais, Brazil., Oliveira E; Laboratório de Pesquisas Clínicas, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil., Reis IA; Departamento de Estatística, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Carneiro M; Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias, Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. mcarneiro@ufmg.br.; Pós-graduação em Ciências da Saúde: Infectologia e Medicina Tropical, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. mcarneiro@ufmg.br. |
| المصدر: | Parasites & vectors [Parasit Vectors] 2018 Nov 12; Vol. 11 (1), pp. 586. Date of Electronic Publication: 2018 Nov 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101462774 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-3305 (Electronic) Linking ISSN: 17563305 NLM ISO Abbreviation: Parasit Vectors Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central |
| مواضيع طبية MeSH: | Endemic Diseases/*prevention & control , Epidemiological Monitoring/*veterinary , Leishmaniasis, Visceral/*veterinary, Animals ; Brazil/epidemiology ; Child ; Child, Preschool ; Cohort Studies ; Cross-Sectional Studies ; Disease Vectors ; Dog Diseases/epidemiology ; Dogs ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Incidence ; Infant ; Leishmania infantum/isolation & purification ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/epidemiology ; Leishmaniasis, Visceral/parasitology ; Male ; Prevalence |
| مستخلص: | Background: Control strategies adopted by the Brazilian Visceral Leishmaniasis Surveillance and Control Programme (VLSCP) include identifying and culling seropositive infected dogs, early diagnosis and treatment of human cases, chemical control of the vector and population awareness. This study evaluated the effectiveness of the VLSCP on the prevalence and incidence rates of Leishmania infantum in children residing in areas under different VLSCP intervention times. Methods: A quasi-experimental epidemiological study with a panel (two cross-sectional) and a concurrent cohort was performed in three areas of Belo Horizonte, southeast Brazil. The first cross-sectional study (I) was carried out with 1875 children, 478 of which were enrolled in the cohort study. In the second cross-sectional study (II), 413 additional children were included, totalizing 891 children. Laboratory diagnosis was performed by ELISA-rK39. Analyses included multilevel logistic and Poisson regression models. Results: The incidence rates of L. infantum infection were: 14.4% in the area where VLSCP intervention was initiated in 2006 (AI2006); 21.1% in the area where intervention was initiated in 2008 (AI2008); and 11.6% in the area where intervention was initiated in 2010 (AI2010 - control area). A follow-up period of 24 months showed that the persons-time incidence rates in AI2006, AI2008, and AI2010 were: 6.2/100, 10/100, and 5.6/100 persons/24 months, respectively. The final prevalence rates of infection (cross-sectional II - in 2012), compared to the initial rates (cross-sectional I - in 2010), increased 83.7% in AI2006, 74.1% in AI2008, and decreased 5% in AI2010. Analysis of the effectiveness revealed that children residing in AI2008 are more likely to be infected (OR = 1.84; 95% CI: 1.06-3.23) and present a higher risk of infection (IRR = 1.76; 95% CI: 1.05-2.95) compared to those in AI2010. No statistically significant differences were observed in asymptomatic infection (OR and IRR) in AI2006 compared to AI2010. Conclusions: The VLSCP was not effective at controlling L. infantum infection in areas where interventions had respectively been carried out for six and four years. However, it is unclear what the consequences in terms of human infection and diseases would be in the absence of the VLSCP. Efforts to improve the effectiveness of control measures remain a necessary priority. |
| References: | Rev Soc Bras Med Trop. 2007 Jul-Aug;40(4):415-9. (PMID: 17876463) Rev Soc Bras Med Trop. 2001 Sep-Oct;34(5):445-51. (PMID: 11600910) Rev Soc Bras Med Trop. 2006 Sep-Oct;39(5):421-7. (PMID: 17160317) Vet Parasitol. 2008 May 6;153(1-2):19-23. (PMID: 18314275) Cad Saude Publica. 2005 Nov-Dec;21(6):1801-7. (PMID: 16410865) Parasitology. 2009 Dec;136(14):1915-34. (PMID: 19835643) Trans R Soc Trop Med Hyg. 2008 Jun;102(6):548-55. (PMID: 18367221) Rev Inst Med Trop Sao Paulo. 2006 May-Jun;48(3):151-6. (PMID: 16847505) PLoS One. 2012;7(5):e35671. (PMID: 22693548) Trans R Soc Trop Med Hyg. 2008 Feb;102(2):172-8. (PMID: 18160087) Clin Infect Dis. 1997 Nov;25(5):1240-2. (PMID: 9402389) Rev Soc Bras Med Trop. 2011 Mar-Apr;44(2):232-42. (PMID: 21468480) PLoS Negl Trop Dis. 2012 Jan;6(1):e1484. (PMID: 22303488) Am J Trop Med Hyg. 2002 Apr;66(4):334-7. (PMID: 12164285) Parasitology. 2017 Apr;144(4):546-556. (PMID: 27894365) Cad Saude Publica. 2008 Dec;24(12):2937-40. (PMID: 19082285) Trends Parasitol. 2011 Sep;27(9):403-9. (PMID: 21596622) Cad Saude Publica. 2016 Jun 20;32(6):. (PMID: 27333135) PLoS Negl Trop Dis. 2014 Oct 30;8(10):e3172. (PMID: 25357122) PLoS Negl Trop Dis. 2013 Nov 07;7(11):e2540. (PMID: 24244776) PLoS Negl Trop Dis. 2009 Oct 20;3(10):e536. (PMID: 19841736) Am J Trop Med Hyg. 2009 Jul;81(1):27-33. (PMID: 19556562) PLoS Negl Trop Dis. 2012;6(12):e1955. (PMID: 23272263) Nature. 1978 Jun 22;273(5664):595-600. (PMID: 351409) Rev Soc Bras Med Trop. 1990 Apr-Jun;23(2):121. (PMID: 2104451) PLoS Negl Trop Dis. 2010 Jan 19;4(1):e584. (PMID: 20098726) |
| معلومات مُعتمدة: | (Grant n°. Universal 78528/2012-4 and 448449/2014-5) Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq (www.cnpq.br); 25000•204799/2013-65 Brazilian Ministry of Health/Fundo Nacional de Saúde; Pesquisador Mineiro (PPM/2016) Fundação de Amaparo a Pesquisa de Minas Gerais - FAPEMIG (www.fapemig.br) |
| فهرسة مساهمة: | Keywords: Control programme; Effectiveness; Leishmania infantum infection; Quasi-experimental study; Visceral leishmaniasis |
| تواريخ الأحداث: | Date Created: 20181114 Date Completed: 20190130 Latest Revision: 20190130 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6233359 |
| DOI: | 10.1186/s13071-018-3166-0 |
| PMID: | 30419944 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder كن أول من يترك تعليقا!