دورية أكاديمية
Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B.
| العنوان: | Linolenic acid-modified methoxy poly (ethylene glycol)-oligochitosan conjugate micelles for encapsulation of amphotericin B. |
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| المؤلفون: | Song Z; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Wen Y; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Deng P; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Teng F; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Zhou F; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Xu H; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Feng S; School of Basic Medical Sciences, Dali University, Dali 671000, Yunnan, PR China., Zhu L; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China., Feng R; School of Biological Science and Technology, University of Jinan, No. 336 West Road of Nanxinzhuang, Jinan 250022, Shandong Province, PR China. Electronic address: runliangfeng@126.com. |
| المصدر: | Carbohydrate polymers [Carbohydr Polym] 2019 Feb 01; Vol. 205, pp. 571-580. Date of Electronic Publication: 2018 Oct 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <1992-> : Barking : Elsevier Applied Science Publishers Original Publication: London [Eng.] : Applied Science Publishers, c1981- |
| مواضيع طبية MeSH: | Micelles*, Amphotericin B/*pharmacology , Antifungal Agents/*pharmacology , Drug Carriers/*chemistry , Linolenic Acids/*chemistry , Polymers/*chemistry, Animals ; Candida albicans/drug effects ; Chitin/analogs & derivatives ; Chitin/chemical synthesis ; Chitin/chemistry ; Chitin/pharmacokinetics ; Chitin/toxicity ; Chitosan ; Drug Carriers/chemical synthesis ; Drug Carriers/pharmacokinetics ; Drug Carriers/toxicity ; Drug Liberation ; Erythrocytes/drug effects ; Hemolysis ; Kidney/drug effects ; Linolenic Acids/chemical synthesis ; Linolenic Acids/pharmacokinetics ; Linolenic Acids/toxicity ; Male ; Mice ; Oligosaccharides ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/pharmacokinetics ; Polyethylene Glycols/toxicity ; Polymers/chemical synthesis ; Polymers/pharmacokinetics ; Polymers/toxicity ; Rats, Sprague-Dawley |
| مستخلص: | Introduction of linolenic acid (LNA) and methoxy poly (ethylene glycol) (MPEG) to the backbone of oligochitosan (CS) afforded LNA-modified MPEG-CS conjugate (MPEG-CS-LNA). Amphotericin B-loaded MPEG-CS-LNA micelles (AmB-M) were prepared via dialysis method with 82.27 ± 1.96% of drug encapsulation efficiency and 10.52 ± 0.22% of drug loading capacity. The AmB-M enhanced AmB's water-solubility to 1.64 mg/mL, being 1640-folds higher than native AmB. The AmB-M obviously reduced hemolytic effect and renal toxicity of AmB when compared to marketed AmB injection (AmB-I). Its antifungal activity against Candida albicans was equivalent to AmB-I although AmB's release from AmB-M was significantly retarded. According to fluorescence microscopy test, the unchanged activity should be attributed to enhanced fungal cellular uptake of AmB-M caused by combined inducement of LNA and CS. The pharmacokinetic studies demonstrated that AmB-M also improved the pharmacokinetic parameters of AmB with AmB-I as control. Conclusively, developed LNA-modified MPEG-CS micellar system could be a viable alternative to the current toxic commercial AmB-I as a highly efficacious drug delivery system. (Copyright © 2018 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Amphotericin B; Antifungal; Chitosan; Linolenic acid; Methoxy poly (ethylene glycol) |
| المشرفين على المادة: | 0 (Antifungal Agents) 0 (Drug Carriers) 0 (Linolenic Acids) 0 (Micelles) 0 (Oligosaccharides) 0 (Polymers) 0 (oligochitosan) 1398-61-4 (Chitin) 3WJQ0SDW1A (Polyethylene Glycols) 7XU7A7DROE (Amphotericin B) 9012-76-4 (Chitosan) |
| تواريخ الأحداث: | Date Created: 20181118 Date Completed: 20181219 Latest Revision: 20211204 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.carbpol.2018.10.086 |
| PMID: | 30446143 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1344 |
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| DOI: | 10.1016/j.carbpol.2018.10.086 |