دورية أكاديمية
أعرض في EDS

Cytotoxicity, antiprotozoal, and anti-inflammatory activities of eight curry powders and comparison of their UPLC-ESI-QTOF-MS chemical profiles.

التفاصيل البيبلوغرافية
العنوان: Cytotoxicity, antiprotozoal, and anti-inflammatory activities of eight curry powders and comparison of their UPLC-ESI-QTOF-MS chemical profiles.
المؤلفون: Sandjo LP; Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Zingue S; Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil.; Department of Live and Earth Sciences, Higher Teachers' Training College, University of Maroua, Maroua, Cameroon., Dos Santos Nascimento MV; Department of Clinical Analysis, Centre of Health Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil., de Moraes MH; Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Vicente G; Department of Clinical Analysis, Centre of Health Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Amoah SK; Metrology Department, Instituto SENAI de Tecnologia em Alimentos e Bebidas, Chapeco, Brazil., Dalmarco EM; Department of Clinical Analysis, Centre of Health Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Frode TS; Department of Clinical Analysis, Centre of Health Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Creczynski-Pasa TB; Department of Pharmaceutical Sciences, Universidade Federal de Santa Catarina, Florianópolis, Brazil., Steindel M; Department of Microbiology, Immunology and Parasitology, Universidade Federal de Santa Catarina, Florianópolis, Brazil.
المصدر: Journal of the science of food and agriculture [J Sci Food Agric] 2019 Apr; Vol. 99 (6), pp. 2987-2997. Date of Electronic Publication: 2019 Jan 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 0376334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0010 (Electronic) Linking ISSN: 00225142 NLM ISO Abbreviation: J Sci Food Agric Subsets: MEDLINE
أسماء مطبوعة: Publication: <2005-> : Chichester, West Sussex : John Wiley & Sons
Original Publication: London, Society of Chemical Industry.
مواضيع طبية MeSH: Anti-Inflammatory Agents/*chemistry , Anti-Inflammatory Agents/*pharmacology , Antiprotozoal Agents/*chemistry , Antiprotozoal Agents/*pharmacology , Plant Extracts/*chemistry , Plant Extracts/*pharmacology , Spices/*analysis, Apoptosis/drug effects ; Cell Line, Tumor ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Humans ; Leishmania/drug effects ; Leishmania/growth & development ; Pleurisy/drug therapy ; Pleurisy/immunology ; Powders/chemistry ; Spectrometry, Mass, Electrospray Ionization ; Trypanosoma cruzi/drug effects ; Trypanosoma cruzi/growth & development
مستخلص: Background: Curry powder is a blend of spices that is extensively consumed worldwide and mainly in Central Asia. Its preparation is strictly related to each locality and, because of the health benefits of its constituents, eight commercial forms of this condiment were biologically and chemically investigated. This study aimed to compare their chemical profile as well as their anti-inflammatory, cytotoxic, and antiparasitic activities.
Results: Curry samples 1 and 7 inhibited leukocyte influx and myeloperoxidase activity, while only 7 was active on protein exudate and NO x species. 2, 6, and 8 displayed trypanocidal effect against Trypanosoma cruzi amastigote, whereas 6 showed antileishmanial activity on Leishmania amazonensis amastigote. 2, 6, and 8 also inhibited the growth of THP-1 cells used as the parasite's host. Among the cytotoxic samples (4 and 6), curry sample 6 induced apoptosis in MDA-MB-231 cells. Nevertheless, 4 and 6 were unselectively cytotoxic to non-tumoral and tumoral cells. The anti-inflammatory, cytotoxicity, and antiparasitic assays were respectively performed by carrageenan-induced pleurisy test, Alamar blue assay, and intracellular parasite-host cell model. Ultra-performance liquid chromatographic-electrospray ionization mass spectrometric data from the spices revealed both similar and different metabolites in their composition.
Conclusion: The results obtained indicate that different formulations can contribute different health benefits as a result of their chemical composition. © 2018 Society of Chemical Industry.
(© 2018 Society of Chemical Industry.)
معلومات مُعتمدة: CNPq (Conselho Nacional de Ciência e Tecnologia)
فهرسة مساهمة: Keywords: Keywords; UPLC-ESI-QTOF-MS; biological activity comparison; chemical profile comparison; curry powder
المشرفين على المادة: 0 (Anti-Inflammatory Agents)
0 (Antiprotozoal Agents)
0 (Plant Extracts)
0 (Powders)
تواريخ الأحداث: Date Created: 20181128 Date Completed: 20190403 Latest Revision: 20190403
رمز التحديث: 20231215
DOI: 10.1002/jsfa.9512
PMID: 30478925
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-0010
DOI:10.1002/jsfa.9512