دورية أكاديمية
Tau Is Elevated in Pediatric Patients on Extracorporeal Membrane Oxygenation.
| العنوان: | Tau Is Elevated in Pediatric Patients on Extracorporeal Membrane Oxygenation. |
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| المؤلفون: | Lee AE; From the Children's Medical Center, Dallas, Texas.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas., Pandiyan P; From the Children's Medical Center, Dallas, Texas.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas., Liu MM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Williams MA; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland., Everett AD; Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland., Mueller GP; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland., Morriss MC; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas., Raman L; From the Children's Medical Center, Dallas, Texas.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas., Carlson D; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Gatson JW; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. |
| المصدر: | ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2020 Jan; Vol. 66 (1), pp. 91-96. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9204109 Publication Model: Print Cited Medium: Internet ISSN: 1538-943X (Electronic) Linking ISSN: 10582916 NLM ISO Abbreviation: ASAIO J Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Philadelphia, PA : Published for the Society by J.B. Lippincott Co., c1992- |
| مواضيع طبية MeSH: | Brain Injuries/*epidemiology , Extracorporeal Membrane Oxygenation/*adverse effects , tau Proteins/*blood, Adolescent ; Biomarkers/blood ; Child ; Child, Preschool ; Extracorporeal Membrane Oxygenation/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Pilot Projects ; Retrospective Studies ; Treatment Outcome |
| مستخلص: | Neurologic injury is a known and feared complication of extracorporeal membrane oxygenation (ECMO). Neurologic biomarkers may have a role in assisting in early identification of such. Axonal biomarker tau has not been investigated in the pediatric ECMO population. The objective of this study is to evaluate plasma levels of tau in pediatric patients supported with ECMO. Eighteen patients requiring ECMO support in a quaternary pediatric intensive care unit at a university-affiliated children's hospital from October 2015 to February 2017 were enrolled. Patients undergoing extracorporeal cardiopulmonary resuscitation or recent history of bypass were excluded. Plasma tau was measured using enzyme-linked immunosorbent assay. Neuroimaging was reviewed for acute neurologic injury, and tau levels were analyzed to assess for correlation. Tau was significantly higher in ECMO patients than in control subjects. Sixty-one percent of subjects had evidence of acute brain injury on neuroimaging, but tau level did not correlate with injury. Subjects with multifocal injury all experienced infarction and had significantly higher tau levels on ECMO day 3 than patients with isolated injury. In addition, peak tau levels of neuro-injured subjects were compared with controls and noninjured ECMO subjects using receiver operating curve analysis. This study demonstrates preliminary evidence of axonal injury in pediatric ECMO patients. |
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| المشرفين على المادة: | 0 (Biomarkers) 0 (tau Proteins) |
| تواريخ الأحداث: | Date Created: 20181204 Date Completed: 20200908 Latest Revision: 20210125 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1097/MAT.0000000000000923 |
| PMID: | 30507848 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1538-943X |
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| DOI: | 10.1097/MAT.0000000000000923 |