دورية أكاديمية
Tau Is Elevated in Pediatric Patients on Extracorporeal Membrane Oxygenation.
العنوان: | Tau Is Elevated in Pediatric Patients on Extracorporeal Membrane Oxygenation. |
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المؤلفون: | Lee AE; From the Children's Medical Center, Dallas, Texas.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas., Pandiyan P; From the Children's Medical Center, Dallas, Texas.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas., Liu MM; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Williams MA; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland., Everett AD; Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland., Mueller GP; Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, Maryland., Morriss MC; Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas., Raman L; From the Children's Medical Center, Dallas, Texas.; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas., Carlson D; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas., Gatson JW; Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. |
المصدر: | ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2020 Jan; Vol. 66 (1), pp. 91-96. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9204109 Publication Model: Print Cited Medium: Internet ISSN: 1538-943X (Electronic) Linking ISSN: 10582916 NLM ISO Abbreviation: ASAIO J Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Hagerstown, MD : Lippincott Williams & Wilkins Original Publication: Philadelphia, PA : Published for the Society by J.B. Lippincott Co., c1992- |
مواضيع طبية MeSH: | Brain Injuries/*epidemiology , Extracorporeal Membrane Oxygenation/*adverse effects , tau Proteins/*blood, Adolescent ; Biomarkers/blood ; Child ; Child, Preschool ; Extracorporeal Membrane Oxygenation/methods ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Pilot Projects ; Retrospective Studies ; Treatment Outcome |
مستخلص: | Neurologic injury is a known and feared complication of extracorporeal membrane oxygenation (ECMO). Neurologic biomarkers may have a role in assisting in early identification of such. Axonal biomarker tau has not been investigated in the pediatric ECMO population. The objective of this study is to evaluate plasma levels of tau in pediatric patients supported with ECMO. Eighteen patients requiring ECMO support in a quaternary pediatric intensive care unit at a university-affiliated children's hospital from October 2015 to February 2017 were enrolled. Patients undergoing extracorporeal cardiopulmonary resuscitation or recent history of bypass were excluded. Plasma tau was measured using enzyme-linked immunosorbent assay. Neuroimaging was reviewed for acute neurologic injury, and tau levels were analyzed to assess for correlation. Tau was significantly higher in ECMO patients than in control subjects. Sixty-one percent of subjects had evidence of acute brain injury on neuroimaging, but tau level did not correlate with injury. Subjects with multifocal injury all experienced infarction and had significantly higher tau levels on ECMO day 3 than patients with isolated injury. In addition, peak tau levels of neuro-injured subjects were compared with controls and noninjured ECMO subjects using receiver operating curve analysis. This study demonstrates preliminary evidence of axonal injury in pediatric ECMO patients. |
References: | Polito A, Barrett CS, Wypij D, et al. Neurologic complications in neonates supported with extracorporeal membrane oxygenation. An analysis of ELSO registry data. Intensive Care Med 2013.39: 1594–1601. Hervey-Jumper SL, Annich GM, Yancon AR, Garton HJ, Muraszko KM, Maher CO. Neurological complications of extracorporeal membrane oxygenation in children. J Neurosurg Pediatr 2011.7: 338–344. Prodhan P, Fiser RT, Cenac S, et al. Intrahospital transport of children on extracorporeal membrane oxygenation: Indications, process, interventions and effectiveness. Pediatr Crit Care Med 2010.11: 227–233. Kochanek PM, Berger RP, Fink EL, et al. The potential for bio-mediators and biomarkers in pediatric traumatic brain injury and neurocritical care. Front Neurol 2013.4: 40. Abdul-Khaliq H, Alexi-Meskhishvili V, Lange PE. Serum S-100 protein levels after pediatric cardiac surgery: A possible new marker for postperfusion cerebral injury. J Thorac Cardiovasc Surg 1999.117: 843–844. Shaaban M, Harmer A, Vaughn R. Serum S100 protein as a marker of cerebral damage during cardiac surgery. Br J Anaesth 2000.85: 287–298. Okonkwo DO, Yue JK, Puccio AM, et al.; Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Investigators: GFAP-BDP as an acute diagnostic marker in traumatic brain injury: Results from the prospective transforming research and clinical knowledge in traumatic brain injury study. J Neurotrauma 2013.30: 1490–1497. Gazzalo D, Masetti P, Meli M, et al. Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracorporeal membrane oxygenation. Acta Paediatr 2002.92:218–221. Bembea MM, Savage W, Strouse JJ, et al. Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med 2011.12: 572–579. Bembea MM, Rizkalla N, Freedy J, et al. Plasma biomarkers of brain injury as diagnostic tools and outcome predictors after extracorporeal membrane oxygenation. Crit Care Med 2015.43: 2202–2211. Floerchinger B, Philipp A, Foltan M, et al. Neuron-specific enolase serum levels predict severe neuronal injury after extracorporeal life support in resuscitation. Eur J Cardiothorac Surg 2014.45: 496–501. Nguyen DN, Huyghens L, Wellens F, et al. Serum S100B protein could help to detect cerebral complications associated with extracorporeal membrane oxygenation (ECMO). Eurocrit Care 2014.20:367–374. Duan AR, Jonasson EM, Alberico EO, et al. Interactions between tau and different conformations of tubulin: Implications for tau function and mechanism. J Mol Biol 2017.429: 1424–1438. Sharma S, Lipincott W. Biomarkers in Alzheimer’s disease-recent update. Curr Alzheimer Res 2017. Zemlan F, Rosenburg W, Luebbe P, et al. Quantification of axonal damage in traumatic brain injury. J Neurochem 1999.72: 741–750. Vile AR, Atkinson L. Chronic traumatic encephalopathy: the cellular sequela to repetitive brain injury. J Clin Neurosc 2017.41: 24–29. Gatson J, Diaz-Arrastia R. Tau as a biomarker of concussion. JAMA Neurol 2014.71:677–678. Pandey S, Singh K, Sharma V, et al. A prospective pilot study on plasma cleaved tau protein as a neurological marker in severe traumatic brain injury. Br J Neurosurg 2017.15: 1–8. Bulut M, Koksal O, Dogan S, et al. Tau protein as a plasma marker of brain damage in mild traumatic brain injury: Preliminary results. Adv Ther 2006.23:12–22. Guzel A, Karasalihoglu S, Aylanc H, et al. Validity of serum tau protein levels in pediatric patients with minor head trauma. Am J Emerg Med 2010.28:399–403. Takahashi K, Hasegawa S, Maeba S, et al. Serum tau protein level serves as a predictive factor for neurological prognosis in neonatal asphyxia. Brain Dev. 2014.36:670–5. Lasek-Bal A, Jedrzejowska-Szypulka H, Rozycka J, et al. The presence of tau protein in blood as a potential prognostic factor in stroke patients. J Physiol Pharmacol 2016.67:691–696. Trakas VE, Fink EL. Serum biomarkers of brain injury: A call for collaboration. Pediatr Crit Care Med 2014.15: 672–673. Ryu JA, Chung CR, Cho YH, et al. The association of findings on brain computed tomography with neurologic outcomes following extracorporeal cardiopulmonary resuscitation. Crit Care 2017.21: 15. Lee NC, Yang SY, Chieh JJ, et al. Blood beta-amyloid and tau in Down syndrome: A comparison with Alzheimer’s disease. Front Aging Neurosci 2016.8: 316. Zetterberg H, Wilson D, Andreasson U, et al. Plasma tau levels in Alzheimer’s disease. Alzheimers Res Ther 2013.5: 9. Tian F, Morriss MC, Chalak L, et al. Impairment of cerebral autoregulation in pediatric extracorporeal membrane oxygenation associated with neuroimaging abnormalities. Neurophotonics 2017.4: 041410. Amerik C, de Mol K, et al. Cerebral aspects of neonatal extracorporeal membrane oxygenation: A review. Neonatology 2013.104:95–103. Vieira RC, Paiva WS, de Oliveira DV, Teixeira MJ, de Andrade AF, de Sousa RM. Diffuse axonal injury: Epidemiology, outcome and associated risk factors. Front Neurol 2016.7: 178. Nikić I, Merkler D, Sorbara C, et al. A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med 2011.17: 495–499. Rammohan KW. Axonal injury in multiple sclerosis. Curr Neurol Neurosci Rep 2003.3: 231–237. |
المشرفين على المادة: | 0 (Biomarkers) 0 (tau Proteins) |
تواريخ الأحداث: | Date Created: 20181204 Date Completed: 20200908 Latest Revision: 20210125 |
رمز التحديث: | 20240628 |
DOI: | 10.1097/MAT.0000000000000923 |
PMID: | 30507848 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1538-943X |
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DOI: | 10.1097/MAT.0000000000000923 |