دورية أكاديمية
أعرض في EDS

Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome.

التفاصيل البيبلوغرافية
العنوان: Minimal difference in phenotype between adolescents and young adults with polycystic ovary syndrome.
المؤلفون: Zore T; Department of Obstetrics and Gynecology, University of California, Los Angeles, California., Lizneva D; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Medical Company IDK, Samara, Russian Federation; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation., Brakta S; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia., Walker W; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia., Suturina L; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation., Azziz R; Department of Obstetrics and Gynecology, University of California, Los Angeles, California; Department of Obstetrics and Gynecology, Augusta University, Augusta, Georgia; Department of Reproductive Health Protection, Scientific Center of Family Health and Human Reproduction, Irkutsk, Russian Federation; Department of Health Policy, Management, and Behavior, School of Public Health, State University of New York, Albany, New York. Electronic address: ricardo.azziz@suny.edu.
المصدر: Fertility and sterility [Fertil Steril] 2019 Feb; Vol. 111 (2), pp. 389-396. Date of Electronic Publication: 2018 Dec 07.
نوع المنشور: Comparative Study; Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier for the American Society for Reproductive Medicine Country of Publication: United States NLM ID: 0372772 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-5653 (Electronic) Linking ISSN: 00150282 NLM ISO Abbreviation: Fertil Steril Subsets: MEDLINE
أسماء مطبوعة: Publication: New York. NY : Elsevier for the American Society for Reproductive Medicine
Original Publication: New York, Hoeber.
مواضيع طبية MeSH: Polycystic Ovary Syndrome/*epidemiology, Acne Vulgaris/blood ; Acne Vulgaris/diagnosis ; Acne Vulgaris/epidemiology ; Adolescent ; Age Factors ; Alabama/epidemiology ; Amenorrhea/blood ; Amenorrhea/diagnosis ; Amenorrhea/epidemiology ; Biomarkers/blood ; Body Mass Index ; Cross-Sectional Studies ; Dehydroepiandrosterone Sulfate/blood ; Female ; Hirsutism/blood ; Hirsutism/diagnosis ; Hirsutism/epidemiology ; Humans ; Hyperandrogenism/blood ; Hyperandrogenism/diagnosis ; Hyperandrogenism/epidemiology ; Obesity/diagnosis ; Obesity/epidemiology ; Oligomenorrhea/blood ; Oligomenorrhea/diagnosis ; Oligomenorrhea/epidemiology ; Phenotype ; Polycystic Ovary Syndrome/blood ; Polycystic Ovary Syndrome/diagnosis ; Prevalence ; Risk Factors ; Severity of Illness Index ; Sex Hormone-Binding Globulin/analysis ; Testosterone/blood ; Young Adult
مستخلص: Objective: To test the hypothesis that the polycystic ovary syndrome (PCOS) phenotype, or its component features, is less severe in adolescents than in young adult patients, in a referred (clinical) population.
Design: Cross-sectional study.
Setting: Tertiary-care academic medical center.
Patient(s): Two hundred seventy-four adolescents and young adults aged 13.0-24.9 years with PCOS according to the National Institute of Health 1990 criteria. Patients were categorized as adolescents (AD: 13.0-18.9 years; n = 91) and young adults (YA: 19.0-24.9 years; n = 183). Adolescents were further categorized as early adolescents (Early-AD: 13.0-15.9 years; n = 31) and late adolescents (Late-AD: 16.0-18.9 years; n = 60).
Intervention(s): History, physical examination, hormonal assays with the use of standardized protocols.
Main Outcome Measure(s): Unadjusted and adjusted odds ratios (ORs; adjusted for body mass index [BMI] when applicable) were calculated for biochemical hyperandrogenism (HA), hirsutism (HIR), acne, and degree of oligo/amenorrhea (OA). PCOS phenotypes were classified as HIR+HA+OA, HA+OA, and HIR+OA.
Result(s): Our analysis demonstrated minimal significant difference in the prevalence of the three PCOS phenotypes, or component features, between AD and YA patients. The risks for obesity were higher for YA versus AD, and the risk of acne was lower for YA versus AD. There was no significant difference between Early-AD and Late-AD. BMI-adjusted models did not significantly modify the main findings.
Conclusion(s): The present study suggests that the PCOS phenotype is established in early adolescence, remains constant into adulthood, and is not related to BMI.
(Copyright © 2018 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Fertil Steril. 2019 Feb;111(2):266-267. (PMID: 30691628)
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معلومات مُعتمدة: R01 HD029364 United States HD NICHD NIH HHS
فهرسة مساهمة: Keywords: PCOS; adolescents; obesity; phenotypes
المشرفين على المادة: 0 (Biomarkers)
0 (Sex Hormone-Binding Globulin)
3XMK78S47O (Testosterone)
57B09Q7FJR (Dehydroepiandrosterone Sulfate)
تواريخ الأحداث: Date Created: 20181212 Date Completed: 20190528 Latest Revision: 20230619
رمز التحديث: 20230620
مُعرف محوري في PubMed: PMC10275352
DOI: 10.1016/j.fertnstert.2018.10.020
PMID: 30527835
قاعدة البيانات: MEDLINE
الوصف
تدمد:1556-5653
DOI:10.1016/j.fertnstert.2018.10.020