دورية أكاديمية
أعرض في EDS

Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.

التفاصيل البيبلوغرافية
العنوان: Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma.
المؤلفون: Russo A; Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil., Biselli-Chicote PM; Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil., Kawasaki-Oyama RS; Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil., Castanhole-Nunes MMU; Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil., Maniglia JV; Department of Otorhinolaryngology and Head and Neck Surgery, FAMERP, São José do Rio Preto, SP 15090-000, Brazil., de Santi Neto D; Department of Pathology, FAMERP, São José do Rio Preto, SP 15090-000, Brazil., Pavarino ÉC; Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil., Goloni-Bertollo EM; Department of Molecular Biology: Biological and Genetics and Molecular Biology Research Unit - UPGEM, São José do Rio Preto Medical School - FAMERP, São José do Rio Preto, SP 15090-000, Brazil.
المصدر: Journal of oncology [J Oncol] 2018 Nov 08; Vol. 2018, pp. 6301980. Date of Electronic Publication: 2018 Nov 08 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Publishing Corporation Country of Publication: Egypt NLM ID: 101496537 Publication Model: eCollection Cited Medium: Print ISSN: 1687-8450 (Print) Linking ISSN: 16878450 NLM ISO Abbreviation: J Oncol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Cairo : Hindawi Publishing Corporation
مستخلص: Introduction: Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor development.
Objective: We aimed to identify the expression profile of these genes, searching for susceptibility biomarkers in oral squamous cell carcinoma.
Patients and Methods: Sixteen oral squamous cell carcinoma samples were included in this study (eight tumor and eight adjacent non-tumor tissues). Gene expression quantification was performed using TaqMan Array Human CYP450 and other Oxygenases 96-well plate (Applied Biosystems) by real time qPCR. Protein quantification was performed by ELISA and IHC methods. Bioinformatics tools were used to find metabolic pathways related to the enzymes encoded by differentially expressed genes. Results. CYP27B1, CYP27A1, CYP2E1, CYP2R1, CYP2J2, CYP2U1, CYP4F12, CYP4X1, CYP4B1, PTGIS, ALOX12, and MAOB genes presented differential expression in the oral tumors. After correction by multiple tests, only the PTGIS (Prostaglandin I2 Synthase) gene presented significant differential expression (P < 0.05). The PTGIS gene and protein were reduced in oral tumors.
Conclusion: PTGIS presents downexpression in oral tumors. PTGIS play an important role in the arachidonic acid metabolism. Arachidonic acid and/or metabolites are derived from this pathway, which can influence the regulation of important physiological mechanisms in tumorigenesis process.
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تواريخ الأحداث: Date Created: 20181212 Latest Revision: 20220330
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6250001
DOI: 10.1155/2018/6301980
PMID: 30532780
قاعدة البيانات: MEDLINE
الوصف
تدمد:1687-8450
DOI:10.1155/2018/6301980