دورية أكاديمية
Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells.
| العنوان: | Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells. |
|---|---|
| المؤلفون: | Karrich JJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Romera-Hernández M; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Papazian N; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Veenbergen S; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center, Rotterdam, The Netherlands., Cornelissen F; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Aparicio-Domingo P; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Stenhouse FH; MRC, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Peddie CD; MRC, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Hoogenboezem RM; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., den Hollander CWJ; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands., Gaskell T; MRC, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Medley T; MRC, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Boon L; Bioceros B.V., Utrecht, The Netherlands., Blackburn CC; MRC, Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, UK., Withers DR; MRC, Centre for Immune Regulation, University of Birmingham, Birmingham, UK., Samsom JN; Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus University Medical Center, Rotterdam, The Netherlands., Cupedo T; Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands. |
| المصدر: | European journal of immunology [Eur J Immunol] 2019 Feb; Vol. 49 (2), pp. 290-301. Date of Electronic Publication: 2018 Dec 14. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 1273201 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-4141 (Electronic) Linking ISSN: 00142980 NLM ISO Abbreviation: Eur J Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Weinheim : Wiley-VCH Original Publication: Weinheim, Verlag Chemie GmbH. |
| مواضيع طبية MeSH: | Cell Movement/*immunology , Dendritic Cells/*metabolism , Gene Expression Regulation/*immunology , Intestine, Small/*immunology , Pregnancy Proteins/*immunology, Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Cell Movement/genetics ; Mice ; Mice, Knockout ; Pregnancy Proteins/genetics |
| مستخلص: | Under homeostatic conditions, dendritic cells (DCs) continuously patrol the intestinal lamina propria. Upon antigen encounter, DCs initiate C-C motif chemokine receptor 7 (CCR7) expression and migrate into lymph nodes to direct T cell activation and differentiation. The mechanistic underpinnings of DC migration from the tissues to lymph nodes have been largely elucidated, contributing greatly to our understanding of DC functionality and intestinal immunity. In contrast, the molecular mechanisms allowing DCs to efficiently migrate through the complex extracellular matrix of the intestinal lamina propria prior to antigen encounter are still incompletely understood. Here we show that small intestinal murine CD11b + CD103 + DCs express Placenta-expressed transcript 1 (Plet1), a glycophoshatidylinositol (GPI)-anchored surface protein involved in migration of keratinocytes during wound healing. In the absence of Plet1, CD11b + CD103 + DCs display aberrant migratory behavior, and accumulate in the small intestine, independent of CCR7 responsiveness. RNA-sequencing indicated involvement of Plet1 in extracellular matrix-interactiveness, and subsequent in-vitro migration assays revealed that Plet1 augments the ability of DCs to migrate through extracellular matrix containing environments. In conclusion, our findings reveal that expression of Plet1 facilitates homeostatic interstitial migration of small intestinal DCs. (© 2018 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.) |
| References: | Cell. 1999 Oct 1;99(1):23-33. (PMID: 10520991) Neuron. 2000 Jul;27(1):33-44. (PMID: 10939329) Nat Immunol. 2001 Apr;2(4):361-7. (PMID: 11276208) Nat Immunol. 2002 Jul;3(7):635-42. (PMID: 12068292) Immunity. 2002 Jun;16(6):803-14. (PMID: 12121662) Genomics. 2004 Jul;84(1):114-25. (PMID: 15203209) Cereb Cortex. 2005 Oct;15(10):1632-6. (PMID: 15703255) J Immunol. 2005 May 1;174(9):5279-87. (PMID: 15843524) Nat Rev Immunol. 2005 Aug;5(8):617-28. (PMID: 16056255) Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50. (PMID: 16199517) Zoolog Sci. 2005 Sep;22(9):995-1001. (PMID: 16219980) J Immunol. 2006 Jan 15;176(2):803-10. (PMID: 16393963) Mol Endocrinol. 2006 May;20(5):1177-87. (PMID: 16469767) J Exp Med. 2006 Mar 20;203(3):519-27. (PMID: 16533884) Biol Pharm Bull. 2006 May;29(5):896-902. (PMID: 16651715) Development. 2006 Aug;133(15):3027-37. (PMID: 16818453) J Immunol. 2006 Aug 1;177(3):1567-74. (PMID: 16849464) Annu Rev Immunol. 2008;26:293-316. (PMID: 18045026) J Neurosci. 2007 Dec 12;27(50):13854-65. (PMID: 18077697) Proc Natl Acad Sci U S A. 2008 Jan 22;105(3):961-6. (PMID: 18195351) Nature. 2008 May 1;453(7191):51-5. (PMID: 18451854) Nat Immunol. 2008 Oct;9(10):1091-4. (PMID: 18800157) J Invest Dermatol. 2010 Jun;130(6):1500-13. (PMID: 20130590) Dev Biol. 2012 Mar 1;363(1):138-46. (PMID: 22227295) Mucosal Immunol. 2012 Sep;5(5):567-79. (PMID: 22617837) Nat Immunol. 2012 Sep;13(9):888-99. (PMID: 22797772) Eur J Immunol. 2012 Dec;42(12):3150-66. (PMID: 22936024) Neuron. 2012 Oct 18;76(2):353-69. (PMID: 23083738) Immunity. 2013 Mar 21;38(3):581-95. (PMID: 23395676) Nat Rev Mol Cell Biol. 2013 Aug;14(8):467-73. (PMID: 23839578) Eur J Immunol. 2013 Dec;43(12):3098-107. (PMID: 23966272) Adv Immunol. 2013;120:51-68. (PMID: 24070380) Cell. 2014 Apr 10;157(2):369-381. (PMID: 24703711) Trends Immunol. 2014 Jun;35(6):270-7. (PMID: 24794393) J Immunol. 2014 Nov 15;193(10):4904-13. (PMID: 25297875) Nat Protoc. 2015 Jun;10(6):845-58. (PMID: 25950237) Immunity. 2015 Jun 16;42(6):1197-211. (PMID: 26084029) J Immunol. 2015 Sep 15;195(6):2888-99. (PMID: 26259586) Curr Opin Cell Biol. 2017 Oct;48:72-78. (PMID: 28641118) Gastroenterology. 1988 Feb;94(2):257-65. (PMID: 3335305) J Invest Dermatol. 1996 Mar;106(3):553-8. (PMID: 8648193) Eur J Immunol. 1998 May;28(5):1673-80. (PMID: 9603474) |
| معلومات مُعتمدة: | 110199/Z/15/Z United Kingdom WT_ Wellcome Trust |
| فهرسة مساهمة: | Keywords: CD103; Intestinal dendritic cells; Migration; Plet1; Wound healing |
| المشرفين على المادة: | 0 (Antigens, CD) 0 (Plet-1 protein, mouse) 0 (Pregnancy Proteins) |
| تواريخ الأحداث: | Date Created: 20181212 Date Completed: 20200519 Latest Revision: 20210109 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6492104 |
| DOI: | 10.1002/eji.201847671 |
| PMID: | 30537036 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!