دورية أكاديمية
Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity.
| العنوان: | Ageing influences the relationship of circulating miR-33a and miR- 33b levels with insulin resistance and adiposity. |
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| المؤلفون: | Corona-Meraz FI; 1 Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.; 2 UDG-CA-701, Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México., Vázquez-Del Mercado M; 1 Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.; 3 Servicio de Reumatología, División de Medicina Interna, Hospital Civil 'Dr. Juan I. Menchaca', Universidad de Guadalajara, Guadalajara, México.; 4 UDG-CA-703, Grupo de Investigación en Inmunología y Reumatología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México., Ortega FJ; 5 CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; 6 Service of Diabetes, Endocrinology and Nutrition (UDEN), Institut d'Investigació Biomédica de Girona (IDIBGI), Girona, Spain., Ruiz-Quezada SL; 7 UDG-CA-817 Investigación Genómica y Biomédica, Departamento de Farmacobiología, Centro Universitario de Ciencias Exactas e Ingenierías, Universidad de Guadalajara, Guadalajara, México., Guzmán-Ornelas MO; 8 Departamento de Ciencias de la Salud-Enfermedad como Proceso Individual, División de Ciencias de la Salud, Centro Universitario de Tonalá, Universidad de Guadalajara, Tonalá, México., Navarro-Hernández RE; 1 Instituto de Investigación en Reumatología y del Sistema Musculo Esquelético, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México.; 2 UDG-CA-701, Grupo de Investigación Inmunometabolismo en Enfermedades Emergentes, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, México. |
| المصدر: | Diabetes & vascular disease research [Diab Vasc Dis Res] 2019 May; Vol. 16 (3), pp. 244-253. Date of Electronic Publication: 2018 Dec 11. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: England NLM ID: 101234011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8984 (Electronic) Linking ISSN: 14791641 NLM ISO Abbreviation: Diab Vasc Dis Res |
| أسماء مطبوعة: | Publication: 2009- : London : Sage Publications Original Publication: Edgbaston, Birmingham, UK : Sherborne Gibbs, c2005- |
| مواضيع طبية MeSH: | Adiposity*/genetics , Insulin Resistance*/genetics, Aging/*blood , Circulating MicroRNA/*blood , MicroRNAs/*blood, Adult ; Aging/genetics ; Blood Glucose/metabolism ; Circulating MicroRNA/genetics ; Cross-Sectional Studies ; Electric Impedance ; Female ; Health Status ; Humans ; Insulin/blood ; Lipids/blood ; Male ; MicroRNAs/genetics ; Middle Aged ; Reverse Transcriptase Polymerase Chain Reaction ; Young Adult |
| مستخلص: | Objective: The identification of circulating microRNAs related to abnormal metabolic function may be useful in the context of ageing, adiposity and insulin resistance. The miR-33 a/b has been shown to control the expression of genes involved in fatty acid biosynthesis, impaired metabolism and insulin resistance. In this study, we aimed to identify differences in circulating miR-33 a/b levels according to age-related metabolic impairment and increased adiposity. Methods: This study included 80 individuals (30.2% with obesity, 70% females) classified according to insulin resistance (Stern's criteria) and age [young (20-39 years) and senior (40-59 years)]. Body fat was evaluated using bioelectrical impedance, biochemical markers by colorimetric, enzymatic and immuno-turbidimetry methods. TaqMan measures of circulating miR-33 a and miR-33 b with quantitative reverse transcription polymerase chain reaction in serum were assessed in association with clinical outputs. Results: Circulating miR-33 a and miR-33 b levels showed significant association with fatness, the lipid profile and biomarkers of impaired glucose metabolism. Both miR-33 a and miR-33 b were associated with visceral adiposity index in non-insulin resistance and insulin resistance individuals. More important, for miR-33 a circulating levels in senior group, receiver operating characteristic curve analyses showed area under the curve 0.804 ( p = 0.010; 95% confidence interval = 0.655-0.952). Conclusion: Ageing influenced the relationship of circulating miR-33 a and miR-33 b with insulin resistance and increased adiposity. |
| فهرسة مساهمة: | Keywords: ; Insulin resistance; ageing; body adiposity; metabolic markers; microRNAs |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (Circulating MicroRNA) 0 (Insulin) 0 (Lipids) 0 (MIRN33a microRNA, human) 0 (MicroRNAs) |
| تواريخ الأحداث: | Date Created: 20181213 Date Completed: 20190813 Latest Revision: 20200205 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1177/1479164118816659 |
| PMID: | 30537863 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1752-8984 |
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| DOI: | 10.1177/1479164118816659 |