دورية أكاديمية
أعرض في EDS

Detection of neuraminidase inhibitor-resistant influenza A (H1N1)pdm09 viruses obtained from influenza surveillance in Indonesia.

التفاصيل البيبلوغرافية
العنوان: Detection of neuraminidase inhibitor-resistant influenza A (H1N1)pdm09 viruses obtained from influenza surveillance in Indonesia.
المؤلفون: Pawestri HA; National Institute of Health Research Development, Ministry of Health, Jakarta, Republic of Indonesia., Nugraha AA; National Institute of Health Research Development, Ministry of Health, Jakarta, Republic of Indonesia., Hariastuti NI; National Institute of Health Research Development, Ministry of Health, Jakarta, Republic of Indonesia., Setiawaty V; National Institute of Health Research Development, Ministry of Health, Jakarta, Republic of Indonesia.
المصدر: SAGE open medicine [SAGE Open Med] 2018 Dec 10; Vol. 6, pp. 2050312118818293. Date of Electronic Publication: 2018 Dec 10 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: SAGE Publications Country of Publication: England NLM ID: 101624744 Publication Model: eCollection Cited Medium: Print ISSN: 2050-3121 (Print) Linking ISSN: 20503121 NLM ISO Abbreviation: SAGE Open Med Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : SAGE Publications
مستخلص: Background: Influenza antiviral resistance has been shown to occur in many countries and is commonly found in influenza A(H1N1)pdm09 and A(H3N2). In this study, we monitored and investigated the neuraminidase inhibitor resistance of influenza A(H1N1)pdm09 viruses through the influenza surveillance system in Indonesia.
Methods: A total of 4752 clinical specimens were collected from patients with influenza-like illness and severe acute respiratory infection during the year 2016. An allelic discrimination assay was conducted by a single base substitution or a single-nucleotide polymorphism that is specific to the H275 wild-type and Y275 mutant. Sequencing was performed to confirm the H275Y mutations, and we analysed the phylogenetic relationship.
Results: The first occurrence of oseltamivir-resistant influenza A(H1N1)pdm09 was observed in the samples from the influenza-like illness surveillance. Two H275Y oseltamivir-resistant viruses (0.74%) out of 272 influenza A(H1N1)pdm09 positives were found. Both of them were collected from untreated patients.
Conclusion: The number of oseltamivir-resistant influenza A(H1N1)pdm09 viruses in Indonesia is very low. However, it is necessary to continue with active surveillance for oseltamivir resistance in severe and mild cases.
Competing Interests: Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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فهرسة مساهمة: Keywords: Neuraminidase inhibitor resistant; influenza A(H1N1)pdm09; surveillance
تواريخ الأحداث: Date Created: 20181222 Latest Revision: 20220330
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC6295675
DOI: 10.1177/2050312118818293
PMID: 30574303
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-3121
DOI:10.1177/2050312118818293