دورية أكاديمية
Association of Copy Number Variation at Intron 3 of HMGA2 With Navel Length in Bos indicus .
| العنوان: | Association of Copy Number Variation at Intron 3 of HMGA2 With Navel Length in Bos indicus . |
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| المؤلفون: | Aguiar TS; Department of Preventive Veterinary Medicine and Animal Reproduction, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil., Torrecilha RBP; Department of Preventive Veterinary Medicine and Animal Reproduction, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil., Milanesi M; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil.; Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil.; Department of Animal Science Food and Nutrition and Biodiversity and Ancient DNA Research Center - BioDNA, Università Cattolica del Sacro Cuore, Piacenza, Italy., Utsunomiya ATH; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil.; Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil., Trigo BB; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil.; Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil., Tijjani A; Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom., Musa HH; Faculty of Medical Laboratory Sciences, University of Khartoum, Khartoum, Sudan., Lopes FL; Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil., Ajmone-Marsan P; Department of Animal Science Food and Nutrition and Biodiversity and Ancient DNA Research Center - BioDNA, Università Cattolica del Sacro Cuore, Piacenza, Italy., Carvalheiro R; Department of Animal Science, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil., Neves HHR; GenSys Consultores Associados, Porto Alegre, Brazil., do Carmo AS; Escola de Veterinária e Zootecnia, Universidade Federal de Goiás, Goiânia, Brazil., Hanotte O; Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, United Kingdom.; LiveGene - CTLGH, International Livestock Research Institute, Addis Ababa, Ethiopia., Sonstegard TS; Recombinetics, Inc., Saint Paul, MN, United States., Garcia JF; Department of Preventive Veterinary Medicine and Animal Reproduction, School of Agricultural and Veterinarian Sciences, São Paulo State University, Jaboticabal, Brazil.; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil.; Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil., Utsunomiya YT; Collaborating Centre on Animal Genomics and Bioinformatics, International Atomic Energy Agency, Araçatuba, Brazil.; Department of Support, Production and Animal Health, School of Veterinary Medicine, São Paulo State University, Araçatuba, Brazil. |
| المصدر: | Frontiers in genetics [Front Genet] 2018 Dec 07; Vol. 9, pp. 627. Date of Electronic Publication: 2018 Dec 07 (Print Publication: 2018). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101560621 Publication Model: eCollection Cited Medium: Print ISSN: 1664-8021 (Print) Linking ISSN: 16648021 NLM ISO Abbreviation: Front Genet Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation. |
| مستخلص: | Navel injuries caused by friction against the pasture can promote infection, reproductive problems and costly treatments in beef cattle raised in extensive systems. A haplotype-based genome-wide association study (GWAS) was performed for visual scores of navel length at yearling in Nellore cattle ( Bos indicus ) using data from 2,016 animals and 503,088 single nucleotide polymorphism (SNP) markers. The strongest signal ( p = 1.01 × 10 -9 ) was found on chromosome 5 spanning positions 47.9-48.2 Mbp. This region contains introns 3 and 4 and exons 4 and 5 of the high mobility group AT-hook 2 gene ( HMGA2 ). Further inspection of the region with whole genome sequence data of 21 Nellore bulls revealed correlations between counts of the significant haplotype and copy number gains of a ∼6.2 kbp segment of intron 3 of HMGA2 . Analysis of genome sequences from five African B. indicus and four European Bos taurus breeds revealed that the copy number variant (CNV) is indicine-specific. This intronic CNV was then validated through quantitative polymerase chain reaction (qPCR) using Angus animals as copy neutral controls. Importantly, the CNV was not detectable by means of conventional SNP-based GWAS or SNP probe intensity analyses. Given that HMGA2 affects the expression of the insulin-like growth factor 2 gene ( IGF2 ) together with the pleomorphic adenoma gene 1 ( PLAG1 ), and that the latter has been repeatedly shown to be associated with quantitative traits of economic importance in cattle, these findings highlight the emerging role of variants impacting the insulin-like growth factor pathway to cattle breeding. |
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| فهرسة مساهمة: | Keywords: CNV; HMGA2; IGF2; PLAG1; SNP; bovine; haplotype |
| تواريخ الأحداث: | Date Created: 20181225 Latest Revision: 20201001 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6292862 |
| DOI: | 10.3389/fgene.2018.00627 |
| PMID: | 30581455 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-8021 |
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| DOI: | 10.3389/fgene.2018.00627 |