دورية أكاديمية
أعرض في EDS

There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients.

التفاصيل البيبلوغرافية
العنوان: There Is No Impact of Diabetes on the Endothelial Function of Chronic Kidney Disease Patients.
المؤلفون: Coutinho MN; Federal University of São Paulo, Brazil., Carvalho AB; Federal University of São Paulo, Brazil., Dalboni MA; Federal University of São Paulo, Brazil., Mouro MG; Federal University of São Paulo, Brazil., Higa EMS; Federal University of São Paulo, Brazil., Costa-Hong V; Heart Institute (InCor) of the University of São Paulo Medical School, Brazil., Bortolotto LA; Heart Institute (InCor) of the University of São Paulo Medical School, Brazil., Figueiredo RAO; Folkälsan Research Center, Helsinki, Finland., Canziani MEF; Federal University of São Paulo, Brazil.
المصدر: Journal of diabetes research [J Diabetes Res] 2018 Nov 25; Vol. 2018, pp. 7926473. Date of Electronic Publication: 2018 Nov 25 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Limited Country of Publication: England NLM ID: 101605237 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6753 (Electronic) NLM ISO Abbreviation: J Diabetes Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2019>-: London, United Kingdom : Hindawi Limited
Original Publication: Nasr City, Cairo : Hindawi Publishing Corporation, [2013]-
مواضيع طبية MeSH: Chemokine CXCL12/*blood , Diabetes Mellitus, Type 2/*physiopathology , Endothelium, Vascular/*physiopathology , Renal Insufficiency, Chronic/*physiopathology, Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Endothelial Progenitor Cells ; Female ; Humans ; Male ; Middle Aged ; Nitric Oxide/blood ; Pulse Wave Analysis ; Renal Insufficiency, Chronic/blood ; Renal Insufficiency, Chronic/complications
مستخلص: Background: Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. The aim of this study was to evaluate whether the presence of DM has any additional effect on the endothelial dysfunction of CKD patients.
Methods: We measured endothelial progenitor cells (EPCs), stromal-derived factor 1 alpha (SDF-1 α ), serum and urinary nitric oxide (NO), flow-mediated dilation (FMD), and pulse wave velocity (PWV) in 37 CKD patients with DM (CKD-DM group) and in 37 without DM (CKD group).
Results: CKD-DM group had a higher prevalence of obesity ( P < 0.01), previous myocardial infarction ( P = 0.02), myocardial revascularization ( P = 0.04), and a trend for more peripheral artery disease ( P = 0.07). Additionally, CKD-DM group had higher EPC ( P = 0.001) and PWV ( P < 0.001) values. On the other hand, no difference in SDF-1 α and serum or urinary NO and FMD was observed between the groups.
Conclusions: Endothelial dysfunction is frequent in CKD patients, and an additive effect of diabetes cannot be implicated, suggesting the predominant role of uremia in this condition.
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المشرفين على المادة: 0 (CXCL12 protein, human)
0 (Chemokine CXCL12)
31C4KY9ESH (Nitric Oxide)
تواريخ الأحداث: Date Created: 20190101 Date Completed: 20190415 Latest Revision: 20220330
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC6286770
DOI: 10.1155/2018/7926473
PMID: 30596103
قاعدة البيانات: MEDLINE
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