دورية أكاديمية
أعرض في EDS

Effect of Activated Immunocompetent Cells on the Number of Multipotent Stromal Cells in Bone Marrow Transplants of CBA and CBA/N Mice in a Short Time after Polyvinylpyrrolidone Administration to Animals.

التفاصيل البيبلوغرافية
العنوان: Effect of Activated Immunocompetent Cells on the Number of Multipotent Stromal Cells in Bone Marrow Transplants of CBA and CBA/N Mice in a Short Time after Polyvinylpyrrolidone Administration to Animals.
المؤلفون: Gorskaya YF; Laboratory of Immunity Regulation and Immunological Tolerance, Moscow, Russia. uliya.gorskaya@nearmedic.ru., Tukhvatulin AI; Laboratory of Cell Microbiology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Dzharullaeva AS; Laboratory of Cell Microbiology, N. F. Gamaleya Federal Research Center of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia., Semenova EN; Laboratory of Immunity Regulation and Immunological Tolerance, Moscow, Russia., Nagurskaya EV; Laboratory of Immunity Regulation and Immunological Tolerance, Moscow, Russia., Bekhalo VA; Laboratory of Immunity Regulation and Immunological Tolerance, Moscow, Russia., Nesterenko VG; Laboratory of Immunity Regulation and Immunological Tolerance, Moscow, Russia.
المصدر: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2019 Jan; Vol. 166 (3), pp. 348-352. Date of Electronic Publication: 2019 Jan 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 0372557 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-8221 (Electronic) Linking ISSN: 00074888 NLM ISO Abbreviation: Bull Exp Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Springer
Original Publication: New York, Consultants Bureau.
مواضيع طبية MeSH: Bone Marrow Cells/*drug effects , Cell Communication/*drug effects , Multipotent Stem Cells/*drug effects , Povidone/*pharmacology , Vaccines, Synthetic/*pharmacology, Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/immunology ; Bone Marrow Transplantation ; Cell Communication/immunology ; Cell Count ; Clone Cells ; Host Specificity ; Immunity, Innate/drug effects ; Interleukin-2/blood ; Interleukin-2/immunology ; Interleukin-5/blood ; Interleukin-5/immunology ; Lymphocyte Activation/drug effects ; Male ; Mice ; Mice, Inbred CBA ; Multipotent Stem Cells/cytology ; Multipotent Stem Cells/immunology ; Spleen/cytology ; Spleen/drug effects ; Spleen/immunology ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/immunology
مستخلص: One hour after polyvinylpyrrolidone administration, the content of multipotent stromal cells in the spleen of CBA and CBA/N mice increased almost equally (by 2.5 and 2.9 times, respectively), but in 24 h, the effectiveness of multipotent stromal cell cloning in the spleen of CBA/N mice decreased almost to the control level, whereas in CBA mice, the number of multipotent stromal cells continued to increase. Serum concentration of IL-5, TNFα, and IL-2 in both lines was elevated in 1 h after polyvinylpyrrolidone administration, which is likely to reflect activation of the innate immunity. One day after polyvinylpyrrolidone administration, the number of multipotent stromal cells in bone marrow transplants in the CBA/N→CBA/N and CBA→CBA/N groups remained practically unchanged, while in groups CBA→CBA and CBA/N→CBA it was equally increased (by 3.6 and 3.4 times, respectively). Thus, the number of multipotent stromal cells in bone marrow transplants after 1 day was increased only in groups where recipients (CBA mice) were capable of responding to polyvinylpyrrolidone administration, i.e. the number of stromal cells by this term, was apparently determined by the presence of activated immunocompetent cells. These findings also indicate that activation of the stromal tissue dur ing immune response can have a two-phasic pattern: the first phase (1 h after antigen adminis tration) can be determined by activation of innate immunity receptors (in multipotent stromal cells or other cells) observed in CBA and CBA/N mice, and the second phase occurs during further development of the immune response (that was observed in CBA mice, but not in CBA/N mice due to absence of CD+B-1a lymphocytes). The findings attest to close interactions between the stromal tissue and the immune system.
فهرسة مساهمة: Keywords: MSC; immune response; stromal cells
المشرفين على المادة: 0 (Interleukin-2)
0 (Interleukin-5)
0 (Tumor Necrosis Factor-alpha)
0 (Vaccines, Synthetic)
FZ989GH94E (Povidone)
تواريخ الأحداث: Date Created: 20190111 Date Completed: 20190529 Latest Revision: 20190529
رمز التحديث: 20221213
DOI: 10.1007/s10517-019-04348-9
PMID: 30627912
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-8221
DOI:10.1007/s10517-019-04348-9