دورية أكاديمية
Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits.
| العنوان: | Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits. |
|---|---|
| المؤلفون: | van Setten J; Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands. J.vanSetten@umcutrecht.nl., Verweij N; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mbarek H; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Niemeijer MN; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., Trompet S; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands., Arking DE; McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Gandin I; Research Unit, AREA Science Park, Trieste, Italy., Grarup N; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Hall LM; Department of Cardiovascular Sciences, University of Leicester, Leicester, England.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK., Hemerich D; Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; CAPES Foundation, Ministry of Education of Brazil, Brasília, DF, 70040-020, Brazil., Lyytikäinen LP; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33520, Tampere, Finland., Mei H; Center of Biostatistics and Bioinformatics, University of Mississippi Medical Center, Jackson, MS, 39216, USA., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany., Prins BP; Human Genetics Research Centre, ICCS, St George's University of London, London, UK., Robino A; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykavik, Iceland., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Research Centre, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Asselbergs FW; Division Heart & Lungs, Department of Cardiology, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.; Durrer Center for Cardiovascular Research, Netherlands Heart Institute, Utrecht, The Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, and Farr Institute of Health Informatics Research and Institute of Health Informatics, University College London, London, UK., Boomsma DI; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Research Centre, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Eijgelsheim M; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Hansen T; The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Harris TB; Laboratory of Epidemiology, Demography and Biometry, National Institute on Aging, Bethesda, MD, USA., Heckbert SR; Cardiovascular Health Research Unit and Department of Epidemiology, University of Washington, Seattle, WA, USA., Hottenga JJ; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Iorio A; Cardiovascular Department, 'Ospedali Riuniti and University of Trieste', Trieste, Italy., Kors JA; Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital-The Capital Region, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., MacFarlane PW; Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK., Meitinger T; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Human Genetics, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technische Universität München, Munich, Germany., Nelson CP; Department of Cardiovascular Sciences, University of Leicester, Leicester, England.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK., Raitakari OT; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, and Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, 20520, Finland., Silva Aldana CT; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.; Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogotá, Colombia.; Institute of translational Medicine-IMT-Center For Research in Genetics and Genomics-CIGGUR, GENIUROS Research Group, School of Medicine and Health Sciences, Universidad del Rosario, Rosario, Colombia., Sinagra G; Cardiovascular Department, 'Ospedali Riuniti and University of Trieste', Trieste, Italy., Sinner M; Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Soliman EZ; Epidemiological Cardiology Research Center (EPICARE), Department of Epidemiology and Prevention, Wake Forest University School of Medicine, Winston-Salem, NC, USA., Stoll M; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands.; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands.; Department of Biochemistry, Maastricht University, Maastricht, The Netherlands., Uitterlinden A; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.; Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands., van Duijn CM; Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands., Waldenberger M; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Research unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Gasparini P; DSM, University of Trieste, Trieste, Italy.; IRCCS-Burlo Garofolo Children Hospital, Via dell'Istria 65, Trieste, Italy., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykavik, Iceland., Jamshidi Y; Human Genetics Research Centre, ICCS, St George's University of London, London, UK., Kääb S; Department of Medicine I, Ludwig-Maximilians-Universität, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Kanters JK; Laboratory of Experimental Cardiology, University of Copenhagen, Copenhagen, Denmark., Lehtimäki T; Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Life Sciences, University of Tampere, 33520, Tampere, Finland., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK.; NIHR Barts Cardiovascular Research Centre, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, London, UK., Peters A; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research, Neuherberg, Germany., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, England.; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Groby Road, Leicester, UK., Sotoodehnia N; Cardiovascular Health Research Unit, Division of Cardiology, University of Washington, Seattle, WA, USA., Ulivi S; Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., de Geus EJC; Department of Biological Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands., Stricker B; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands., van der Harst P; Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands., de Bakker PIW; Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands., Isaacs A; CARIM School for Cardiovascular Diseases, Maastricht University, Maastricht, The Netherlands. a.isaacs@maastrichtuniversity.nl.; Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, The Netherlands. a.isaacs@maastrichtuniversity.nl.; Department of Biochemistry, Maastricht University, Maastricht, The Netherlands. a.isaacs@maastrichtuniversity.nl. |
| المصدر: | European journal of human genetics : EJHG [Eur J Hum Genet] 2019 Jun; Vol. 27 (6), pp. 952-962. Date of Electronic Publication: 2019 Jan 24. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9302235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5438 (Electronic) Linking ISSN: 10184813 NLM ISO Abbreviation: Eur J Hum Genet Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: London : Nature Publishing Group Original Publication: Basel ; New York : Karger, [1992- |
| مواضيع طبية MeSH: | Electrocardiography* , Genetic Loci* , Polymorphism, Single Nucleotide*, Female ; Humans ; Male ; Genome-Wide Association Study ; Netherlands |
| مستخلص: | Genome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, we meta-analyzed genome-wide association results from 30,000 mostly Dutch samples on four ECG traits: PR interval, QRS duration, QT interval, and RR interval. SNP genotype data was imputed using the Genome of the Netherlands reference panel encompassing 19 million SNPs, including millions of rare SNPs (minor allele frequency < 5%). In addition to many known loci, we identified seven novel locus-trait associations: KCND3, NR3C1, and PLN for PR interval, KCNE1, SGIP1, and NFKB1 for QT interval, and ATP2A2 for QRS duration, of which six were successfully replicated. At these seven loci, we performed conditional analyses and annotated significant SNPs (in exons and regulatory regions), demonstrating involvement of cardiac-related pathways and regulation of nearby genes. |
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| معلومات مُعتمدة: | PG/12/38/29615 United Kingdom BHF_ British Heart Foundation; U54 GM115428 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20190126 Date Completed: 20200611 Latest Revision: 20240404 |
| رمز التحديث: | 20240405 |
| مُعرف محوري في PubMed: | PMC6777533 |
| DOI: | 10.1038/s41431-018-0295-z |
| PMID: | 30679814 |
| قاعدة البيانات: | MEDLINE |
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