دورية أكاديمية
Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation.
| العنوان: | Dynamic Methylation of an L1 Transduction Family during Reprogramming and Neurodifferentiation. |
|---|---|
| المؤلفون: | Salvador-Palomeque C; Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia., Sanchez-Luque FJ; Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia.; Pfizer-University of Granada-Andalusian Government Center for Genomics and Oncological Research, Granada, Spain., Fortuna PRJ; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Queensland, Australia., Ewing AD; Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia., Wolvetang EJ; Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St. Lucia, Queensland, Australia., Richardson SR; Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia sandra.richardson@mater.uq.edu.au faulknergj@gmail.com., Faulkner GJ; Mater Research Institute, University of Queensland, Woolloongabba, Queensland, Australia sandra.richardson@mater.uq.edu.au faulknergj@gmail.com.; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.; School of Biomedical Sciences, University of Queensland, Brisbane, Queensland, Australia. |
| المصدر: | Molecular and cellular biology [Mol Cell Biol] 2019 Mar 19; Vol. 39 (7). Date of Electronic Publication: 2019 Mar 19 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 8109087 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5549 (Electronic) Linking ISSN: 02707306 NLM ISO Abbreviation: Mol Cell Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [Philadelphia] : Taylor & Francis Original Publication: [Washington, D.C.] : American Society for Microbiology, [c1981- |
| مواضيع طبية MeSH: | Gene Expression Regulation, Developmental/*genetics , Long Interspersed Nucleotide Elements/*genetics , Neurogenesis/*genetics, Cells, Cultured ; DNA Methylation/genetics ; Embryo, Mammalian/metabolism ; Germ Cells/metabolism ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Long Interspersed Nucleotide Elements/physiology ; Neurons/metabolism ; Promoter Regions, Genetic/genetics ; Retroelements/genetics |
| مستخلص: | The retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s (RC-L1s) can generate new heritable L1 insertions in the early embryo, primordial germ line, and germ cells. L1 retrotransposition can also occur in the neuronal lineage and cause somatic mosaicism. Although DNA methylation mediates L1 promoter repression, the temporal pattern of methylation applied to individual RC-L1s during neurogenesis is unclear. Here, we identified a de novo L1 insertion in a human induced pluripotent stem cell (hiPSC) line via retrotransposon capture sequencing (RC-seq). The L1 insertion was full-length and carried 5' and 3' transductions. The corresponding donor RC-L1 was part of a large and recently active L1 transduction family and was highly mobile in a cultured-cell L1 retrotransposition reporter assay. Notably, we observed distinct and dynamic DNA methylation profiles for the de novo L1 and members of its extended transduction family during neuronal differentiation. These experiments reveal how a de novo L1 insertion in a pluripotent stem cell is rapidly recognized and repressed, albeit incompletely, by the host genome during neurodifferentiation, while retaining potential for further retrotransposition. (Copyright © 2019 Salvador-Palomeque et al.) |
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| فهرسة مساهمة: | Keywords: L1; LINE-1; methylation; neurogenesis; retrotransposon |
| المشرفين على المادة: | 0 (Retroelements) |
| تواريخ الأحداث: | Date Created: 20190130 Date Completed: 20191104 Latest Revision: 20200309 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6425141 |
| DOI: | 10.1128/MCB.00499-18 |
| PMID: | 30692270 |
| قاعدة البيانات: | MEDLINE |
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