دورية أكاديمية
Alcohol-Related Liver Disease Is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide.
| العنوان: | Alcohol-Related Liver Disease Is Rarely Detected at Early Stages Compared With Liver Diseases of Other Etiologies Worldwide. |
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| المؤلفون: | Shah ND; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Ventura-Cots M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Center for Liver Diseases, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain., Abraldes JG; Cirrhosis Care Clinic, Division of Gastroenterology (Liver Unit), University of Alberta, Centre of Excellence for Gastrointestinal Inflammation and Immunity Research (CEGIIR), Edmonton, Canada., Alboraie M; Haya Al-Habeeb Gastroenterology Center, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait; Department of Internal Medicine, Al-Azhar University, Cairo, Egypt., Alfadhli A; Haya Al-Habeeb Gastroenterology Center, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait., Argemi J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Center for Liver Diseases, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania; Liver Unit, Clinica Universidad de Navarra, Pamplona, Spain., Badia-Aranda E; Gastroenterology Department, Liver Unit, Hospital Universitario de Burgos, Burgos, Spain., Arús-Soler E; Department of Hepatology, Instituto de Gastroenterología, Havana, Cuba., Barritt AS 4th; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina., Bessone F; Department of Gastroenterology and Hepatology, University of Rosario School of Medicine, Rosario, Argentina., Biryukova M; Department of Gastroenterology and Hepatology, Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia., Carrilho FJ; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil., Fernández MC; Department of Hepatology, Instituto de Gastroenterología, Havana, Cuba., Dorta Guiridi Z; Department of Gastroenterology and Hepatology, Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia., El Kassas M; Endemic Medicine Department, Faculty of Medicine, Helwan University, Cairo, Egypt., Eng-Kiong T; Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore., Queiroz Farias A; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil., George J; Storr Liver Centre, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia., Gui W; Division of Gastroenterology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China., Thurairajah PH; Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore., Hsiang JC; Department of Gastroenterology and Hepatology, Changi General Hospital, Singapore., Husić-Selimovic A; Department of Hepatology, Institute for Gastroenterology, University Hospital Sarajevo, Sarajevo, Bosnia and Herzegovina., Isakov V; Department of Gastroenterology and Hepatology, Federal Research Center for Nutrition, Biotechnology and Food Safety, Moscow, Russia., Karoney M; Department of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya., Kim W; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government, Seoul National University Boramae Medical Center, Seoul, South Korea., Kluwe J; Department of Gastroenterology and Hepatology, University Medical Center, Hamburg-Eppendorf, Germany., Kochhar R; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Dhaka N; Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Costa PM; Departmento de Gastrenterologia e Hepatologia, Centro Hospitalar Lisboa Norte, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Nabeshima Pharm MA; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil., Ono SK; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil., Reis D; Departmento de Gastrenterologia e Hepatologia, Centro Hospitalar Lisboa Norte, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Rodil A; Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil., Domech CR; Department of Hepatology, Instituto de Gastroenterología, Havana, Cuba., Sáez-Royuela F; Gastroenterology Department, Liver Unit, Hospital Universitario de Burgos, Burgos, Spain., Scheurich C; Department of Gastroenterology and Hepatology, University Medical Center, Hamburg-Eppendorf, Germany., Siow W; Storr Liver Centre, Westmead Millennium Institute, Westmead Hospital, University of Sydney, Westmead, New South Wales, Australia., Sivac-Burina N; Department of Hepatology, Institute for Gastroenterology, University Hospital Sarajevo, Sarajevo, Bosnia and Herzegovina., Dos Santos Traquino ES; Department of Hepatology, Instituto de Gastroenterología, Havana, Cuba., Some F; Department of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya., Spreckic S; Department of Hepatology, Institute for Gastroenterology, University Hospital Sarajevo, Sarajevo, Bosnia and Herzegovina., Tan S; Department of Gastoenterology, Renmin Hospital of Wuhan University, Wuhan, China., Vorobioff J; Department of Gastroenterology and Hepatology, University of Rosario School of Medicine, Rosario, Argentina., Wandera A; Department of Medicine, School of Medicine, College of Health Sciences, Moi University, Eldoret, Kenya., Wu P; Department of Gastoenterology, Renmin Hospital of Wuhan University, Wuhan, China., Yacoub M; Hepatology Department, National Hepatology and Tropical Medicine Research Institute, Cairo, Egypt., Yang L; Division of Gastroenterology, Union Hospital, Huazhong University of Science and Technology, Wuhan, China., Yu Y; Department of Gastoenterology, Renmin Hospital of Wuhan University, Wuhan, China., Zahiragic N; Department of Hepatology, Institute for Gastroenterology, University Hospital Sarajevo, Sarajevo, Bosnia and Herzegovina., Zhang C; Department of Gastoenterology, Renmin Hospital of Wuhan University, Wuhan, China., Cortez-Pinto H; Departmento de Gastrenterologia e Hepatologia, Centro Hospitalar Lisboa Norte, Laboratório de Nutrição, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal., Bataller R; Division of Gastroenterology and Hepatology, Departments of Medicine and Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Center for Liver Diseases, Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: bataller@pitt.edu. |
| المصدر: | Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association [Clin Gastroenterol Hepatol] 2019 Oct; Vol. 17 (11), pp. 2320-2329.e12. Date of Electronic Publication: 2019 Jan 29. |
| نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders for the American Gastroenterological Association Country of Publication: United States NLM ID: 101160775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-7714 (Electronic) Linking ISSN: 15423565 NLM ISO Abbreviation: Clin Gastroenterol Hepatol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, PA : W.B. Saunders for the American Gastroenterological Association, 2003- |
| مواضيع طبية MeSH: | Liver/*pathology , Liver Cirrhosis/*epidemiology , Liver Diseases, Alcoholic/*diagnosis , Liver Neoplasms/*epidemiology, Biopsy ; Cross-Sectional Studies ; Disease Progression ; Global Health ; Humans ; Liver Cirrhosis/diagnosis ; Liver Diseases, Alcoholic/epidemiology ; Liver Neoplasms/diagnosis ; Prevalence |
| مستخلص: | Background & Aims: Despite recent advances in treatment of viral hepatitis, liver-related mortality is high, possibly owing to the large burden of advanced alcohol-related liver disease (ALD). We investigated whether patients with ALD are initially seen at later stages of disease development than patients with hepatitis C virus (HCV) infection or other etiologies. Methods: We performed a cross-sectional study of 3453 consecutive patients with either early or advanced liver disease (1699 patients with early and 1754 with advanced liver disease) seen at 17 tertiary care liver or gastrointestinal units worldwide, from August 2015 through March 2017. We collected anthropometric, etiology, and clinical information, as well as and model for end-stage liver disease scores. We used unconditional logistic regression to estimate the odds ratios for evaluation at late stages of the disease progression. Results: Of the patients analyzed, 81% had 1 etiology of liver disease and 17% had 2 etiologies of liver disease. Of patients seen at early stages for a single etiology, 31% had HCV infection, 21% had hepatitis B virus infection, and 17% had nonalcoholic fatty liver disease, whereas only 3.8% had ALD. In contrast, 29% of patients seen for advanced disease had ALD. Patients with ALD were more likely to be seen at specialized centers, with advanced-stage disease, compared with patients with HCV-associated liver disease (odds ratio, 14.1; 95% CI, 10.5-18.9; P < .001). Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. These patients had significantly more visits to health care providers, with more advanced disease, compared with patients without excess alcohol use. The mean model for end-stage liver disease score for patients with advanced ALD (score, 16) was higher than for patients with advanced liver disease not associated with excess alcohol use (score, 13) (P < .01). Conclusions: In a cross-sectional analysis of patients with liver disease worldwide, we found that patients with ALD are seen with more advanced-stage disease than patients with HCV-associated liver disease. Of patients with 2 etiologies of liver disease, excess alcohol use was associated with 50% of cases. Early detection and referral programs are needed for patients with ALD worldwide. (Copyright © 2019 AGA Institute. Published by Elsevier Inc. All rights reserved.) |
| References: | J Hepatol. 2012 Aug;57(2):399-420. (PMID: 22633836) J Hepatol. 2014 Jul;61(1):22-7. (PMID: 24607623) J Hepatol. 2015 Sep;63(3):743-52. (PMID: 26047908) JAMA. 2015 Jun 9;313(22):2263-73. (PMID: 26057287) Hepatology. 2015 Sep;62(3):932-54. (PMID: 26111063) Gastroenterology. 2016 Jan;150(1):123-33. (PMID: 26435270) Hepatology. 2016 Jan;63(1):261-83. (PMID: 26566064) Ann Hepatol. 2016 Mar-Apr;15(2):183-9. (PMID: 26845595) J Hepatol. 2016 Sep;65(3):618-30. (PMID: 27155530) J Hepatol. 2016 Nov;65(5):998-1005. (PMID: 27392424) Am J Transplant. 2017 Jan;17 Suppl 1:174-251. (PMID: 28052604) BMJ Open. 2017 Mar 22;7(3):e013620. (PMID: 28336739) Am J Gastroenterol. 2017 Jun;112(6):821-824. (PMID: 28397875) J Hepatol. 2017 Sep;67(3):559-567. (PMID: 28756907) Lancet. 2017 Sep 16;390(10100):1260-1344. (PMID: 28919118) Hepatology. 1987 Jan-Feb;7(1):122-8. (PMID: 3804191) Addiction. 1993 Jun;88(6):791-804. (PMID: 8329970) |
| معلومات مُعتمدة: | U01 AA020821 United States AA NIAAA NIH HHS; U01 AA021908 United States AA NIAAA NIH HHS |
| فهرسة مساهمة: | Keywords: Cirrhosis; Mortality; NAFLD |
| تواريخ الأحداث: | Date Created: 20190202 Date Completed: 20201209 Latest Revision: 20201214 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6682466 |
| DOI: | 10.1016/j.cgh.2019.01.026 |
| PMID: | 30708110 |
| قاعدة البيانات: | MEDLINE |
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