دورية أكاديمية
Novel Targets of Immunosuppression in Transplantation.
| العنوان: | Novel Targets of Immunosuppression in Transplantation. |
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| المؤلفون: | Shin HS; Renal Division, Department of Internal Medicine, Gospel Hospital, Kosin University College of Medicine, 262 Gamcheon-ro, Seo-gu, Busan 49267, Republic of Korea., Grgic I; Department of Internal Medicine and Nephrology, University Hospital, Giessen and Marburg, Philipps-University Marburg, Baldinger Strasse 1, Marburg 35033, Germany., Chandraker A; Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02215, USA. Electronic address: achandraker@bwh.harvard.edu. |
| المصدر: | Clinics in laboratory medicine [Clin Lab Med] 2019 Mar; Vol. 39 (1), pp. 157-169. Date of Electronic Publication: 2018 Dec 18. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Health Sciences Division Country of Publication: United States NLM ID: 8100174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-9832 (Electronic) Linking ISSN: 02722712 NLM ISO Abbreviation: Clin Lab Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2005->: Philadelphia : Elsevier Health Sciences Division Original Publication: Philadelphia : Saunders, [1981- |
| مواضيع طبية MeSH: | Transplantation*, Immunosuppression Therapy/*methods, Graft Rejection/immunology ; Graft Rejection/prevention & control ; Immunologic Factors/therapeutic use ; Models, Immunological ; T-Lymphocytes/physiology ; Transplantation Conditioning/methods |
| مستخلص: | It is increasingly recognized that calcineurin inhibitors (CNI) such as cyclosporine and tacrolimus are not ideal immunosuppressive agents. Side effects, including increased rates of infection, hypertension, and malignancy, can be severe. Thus, in the past decade, there has been much focus on the development of novel therapeutic agents and strategies designed to replace or minimize CNI exposure in transplant patients. This article reviews potential novel targets in T cells, alloantibody-producing B cells, plasma cells, and complement in transplantation. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: B cell; Complement; Immunosuppression; Novel; Plasma cell; T cell; Target; Transplantation |
| المشرفين على المادة: | 0 (Immunologic Factors) |
| تواريخ الأحداث: | Date Created: 20190203 Date Completed: 20190909 Latest Revision: 20211204 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.cll.2018.10.008 |
| PMID: | 30709504 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1557-9832 |
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| DOI: | 10.1016/j.cll.2018.10.008 |