دورية أكاديمية
Evaluation of whole-body tumor burden with 68 Ga-PSMA PET/CT in the biochemical recurrence of prostate cancer.
| العنوان: | Evaluation of whole-body tumor burden with 68 Ga-PSMA PET/CT in the biochemical recurrence of prostate cancer. |
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| المؤلفون: | Brito AET; Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil. aetbrito@gmail.com.; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil. aetbrito@gmail.com., Mourato FA; Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil., de Oliveira RPM; Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil., Leal ALG; Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil., Filho PJA; Real Nuclear Real Hospital Português de Beneficência em Pernambuco, Av. Gov. Agamenon Magalhães, 4760, Paissandu, Recife, PE, 52010-902, Brazil., de Filho JLL; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, Brazil. |
| المصدر: | Annals of nuclear medicine [Ann Nucl Med] 2019 May; Vol. 33 (5), pp. 344-350. Date of Electronic Publication: 2019 Feb 11. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Japan Country of Publication: Japan NLM ID: 8913398 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1864-6433 (Electronic) Linking ISSN: 09147187 NLM ISO Abbreviation: Ann Nucl Med |
| أسماء مطبوعة: | Publication: Tokyo, Japan : Springer Japan Original Publication: Tokyo, Japan : Japanese Society of Nuclear Medicine, [1987- |
| مواضيع طبية MeSH: | Oligopeptides* , Positron Emission Tomography Computed Tomography* , Tumor Burden*, Edetic Acid/*analogs & derivatives , Prostatic Neoplasms/*diagnostic imaging , Prostatic Neoplasms/*pathology, Adult ; Aged ; Aged, 80 and over ; Gallium Isotopes ; Gallium Radioisotopes ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Prostatic Neoplasms/metabolism ; Recurrence ; Retrospective Studies |
| مستخلص: | Background: 68 Ga-PSMA-PET has an increasing importance in the evaluation of prostate cancer patients due to its high sensitivity and specificity in identifying neoplastic lesions in the clinical setting of elevated prostate-specific antigen (PSA). The objective of this study was to calculate the whole-body tumor burden using volumetric quantification of lesions detected in 68 Ga-PSMA-PET of prostate cancer patients with biochemical recurrence and correlate these findings with clinical and image parameters. Methods: Each patient had their 68 Ga-PSMA-PET analyzed for the presence of neoplastic lesions. Their PSA levels and clinical information were recorded. In positive cases, the tumor burden (TL-PSMA) was calculated with a semi-automatic software and manually, and the results are analyzed and tested. Results: We analyzed 100 prostate cancer patients, mean age of 69.9 ± 9.7 years and a median PSA of 1.73 ng/dL. 68 Ga-PSMA-PET identified neoplastic lesions in 72% of them. The median TL-PSMA was 55.95 ml (1.1-28,080 ml). TL-PSMA and PSA were strongly correlated (rho = 0.71, p < 0.0001, 95% CI 0.60-0.80). TL-PSMA and PSA levels groups had a significant correlation and TL-PSMA and Gleason score were independent variables associated with PSA levels (p < 0.05). Conclusion: TL-PSMA strongly and independently correlates with PSA levels in prostate cancer patients and could be used as a biomarker to separate them into groups with high or low tumor burden, instead of considering only the number of lesions. |
| فهرسة مساهمة: | Keywords: PET/CT; PSA; PSMA; Prostate cancer; Tumor burden |
| المشرفين على المادة: | 0 (Gallium Isotopes) 0 (Gallium Radioisotopes) 0 (Oligopeptides) 0 (gallium 68 PSMA-11) 9G34HU7RV0 (Edetic Acid) |
| تواريخ الأحداث: | Date Created: 20190213 Date Completed: 20190816 Latest Revision: 20211204 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s12149-019-01342-z |
| PMID: | 30746599 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1864-6433 |
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| DOI: | 10.1007/s12149-019-01342-z |