دورية أكاديمية
Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.
| العنوان: | Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation. |
|---|---|
| المؤلفون: | Tajiki-Nishino R; The Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan., Watanabe Y; The Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan., Fukuyama T; The Institute of Environmental Toxicology, 4321, Uchimoriya-machi, Joso-shi, Ibaraki 303-0043, Japan.; Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, 1-17-71, Fuchinobe, Chuo-ku, Sagamihara, Kanagawa 252-5201, Japan. |
| المصدر: | The Journal of veterinary medical science [J Vet Med Sci] 2019 Apr 16; Vol. 81 (4), pp. 541-544. Date of Electronic Publication: 2019 Feb 15. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Japanese Society Of Veterinary Science Country of Publication: Japan NLM ID: 9105360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1347-7439 (Electronic) Linking ISSN: 09167250 NLM ISO Abbreviation: J Vet Med Sci |
| أسماء مطبوعة: | Original Publication: Tokyo : Japanese Society Of Veterinary Science |
| مواضيع طبية MeSH: | Immunosuppressive Agents/*toxicity , Methoxychlor/*toxicity , Parathion/*toxicity , Prenatal Exposure Delayed Effects/*immunology , Respiratory Hypersensitivity/*chemically induced, Animals ; Bronchoalveolar Lavage Fluid/cytology ; Bronchoalveolar Lavage Fluid/immunology ; Cytokines ; Drug Synergism ; Eosinophils ; Female ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Methoxychlor/administration & dosage ; Mice, Inbred BALB C ; Parathion/administration & dosage ; Phthalic Anhydrides/immunology ; Pregnancy ; Respiratory Hypersensitivity/immunology |
| مستخلص: | The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC + PARA exposure compared to that of the control, MXC, and PARA groups. In the hilar lymph node, only slight increases in B-cell infiltration, as well as IL-6 and IL-9 secretions were observed in MXC + PARA group, and no effect was observed in the individual treatment groups. Our findings imply that prenatal exposure to some combinations of multiple chemicals may exacerbate the allergic inflammatory responses including eosinophils and cytokine production. |
| References: | Toxicology. 2002 Apr 2;172(3):205-15. (PMID: 11893419) Science. 2004 Sep 17;305(5691):1773-6. (PMID: 15375267) J Innate Immun. 2011;3(2):113-9. (PMID: 21228563) J Allergy Clin Immunol. 2012 Apr;129(4):974-82.e13. (PMID: 22385633) J Immunotoxicol. 2013 Apr-Jun;10(2):150-9. (PMID: 22834942) J Immunotoxicol. 2014 Oct;11(4):359-66. (PMID: 24188624) Immunopharmacol Immunotoxicol. 2014 Aug;36(4):261-70. (PMID: 24935097) Exp Anim. 2014;63(4):435-45. (PMID: 25048268) Toxicology. 2019 Jan 1;411:93-100. (PMID: 30445053) J Agric Food Chem. 1970 Nov-Dec;18(6):1145-52. (PMID: 5483054) Proc Soc Exp Biol Med. 1984 Jun;176(2):187-96. (PMID: 6718363) J Toxicol Environ Health. 1978 Sep-Nov;4(5-6):881-93. (PMID: 731734) Fundam Appl Toxicol. 1997 Nov;40(1):138-57. (PMID: 9398496) |
| فهرسة مساهمة: | Keywords: allergic airway inflammation; combined toxicity; methoxychlor; parathion; prenatal exposure |
| المشرفين على المادة: | 0 (Cytokines) 0 (Immunosuppressive Agents) 0 (Phthalic Anhydrides) 61G466064D (Parathion) 80T61EUU7H (trimellitic anhydride) RIA79UD69L (Methoxychlor) |
| تواريخ الأحداث: | Date Created: 20190219 Date Completed: 20190807 Latest Revision: 20200225 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6483908 |
| DOI: | 10.1292/jvms.18-0641 |
| PMID: | 30773519 |
| قاعدة البيانات: | MEDLINE |
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