دورية أكاديمية
In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis.
| العنوان: | In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis. |
|---|---|
| المؤلفون: | Curcio JS; Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus II Samambaia, Goiânia, GO, Brazil.; Programa de Pós-Graduação em Patologia Molecular, Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brazil., Batista MP; Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus II Samambaia, Goiânia, GO, Brazil., Paccez JD; Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus II Samambaia, Goiânia, GO, Brazil., Novaes E; Departamento de Biologia, Universidade Federal de Lavras, Minas Gerais, Brazil., Soares CMA; Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus II Samambaia, Goiânia, GO, Brazil. |
| المصدر: | Genetics and molecular biology [Genet Mol Biol] 2019 Jan-Mar; Vol. 42 (1), pp. 95-107. Date of Electronic Publication: 2019 Feb 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sociedade Brasileira de Genética Country of Publication: Brazil NLM ID: 100883590 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1415-4757 (Print) Linking ISSN: 14154757 NLM ISO Abbreviation: Genet Mol Biol Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Ribeirão Preto, SP, Brazil : Sociedade Brasileira de Genética, 1998- |
| مستخلص: | Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation of targets by cleavage or degradation of the mRNA. Fungi of the Paracoccidioides complex are the etiological agents of the main systemic mycosis of Latin America. These fungi present a plasticity to adapt and survive in different conditions, and the presence of microRNAs-like molecules could be part of the mechanisms that provide such plasticity. MicroRNAs produced by the host influence the progression of this mycosis in the lungs besides regulating targets involved in apoptosis in macrophage, activation of T and B cells and the production of cytokines. Therefore, this work analyzed the presence of regions in the genome of this fungus with a potential to encode microRNAs-like molecules. Here we show by analysis of sequence similarity the presence of 18 regions, putatively coding for microRNAs-like molecules in the Paracoccidioides brasiliensis genome. We also described the conservation of dicer and argonaut proteins and the cognate transcripts induced in the yeast parasitic phase. This work represents a starting point for the analysis of the presence of those molecules in the morphological stages of the fungus and their role in fungal development. |
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| تواريخ الأحداث: | Date Created: 20190219 Latest Revision: 20200929 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6428129 |
| DOI: | 10.1590/1678-4685-GMB-2018-0014 |
| PMID: | 30776047 |
| قاعدة البيانات: | MEDLINE |
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