دورية أكاديمية
A possible link between polyunsaturated fatty acids and uremic toxins from the gut microbiota in hemodialysis patients: A hypothesis.
| العنوان: | A possible link between polyunsaturated fatty acids and uremic toxins from the gut microbiota in hemodialysis patients: A hypothesis. |
|---|---|
| المؤلفون: | Kemp JA; Post-Graduate Program in Medical Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil., Esgalhado M; Post-Graduate Program in Cardiovascular Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil., Macedo RA; Post-Graduate Program in Cardiovascular Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil., Regis B; Post-Graduate Program in Medical Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil., Damasceno NRT; Department of Nutrition, Faculty of Public Health Nutrition, São Paulo University, São Paulo, Brazil., da Silva Torres EAF; Department of Nutrition, Faculty of Public Health Nutrition, São Paulo University, São Paulo, Brazil., Gonçalinho GHF; Department of Nutrition, Faculty of Public Health Nutrition, São Paulo University, São Paulo, Brazil., Borges NA; Post-Graduate Program in Cardiovascular Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil., Nakao LS; Basic Pathology Department, Federal University of Paraná (UFPR), Curitiba, Puerto Rico, Brazil., Fouque D; Department of Nephrology, Centre Hopitalier Lyon Sud, INSERM 1060, CENS, Université de Lyon, France., Mafra D; Post-Graduate Program in Medical Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil.; Post-Graduate Program in Cardiovascular Sciences, Federal University Fluminense (UFF), Niterói, Rio de Janeiro, Brazil. |
| المصدر: | Hemodialysis international. International Symposium on Home Hemodialysis [Hemodial Int] 2019 Apr; Vol. 23 (2), pp. 189-197. Date of Electronic Publication: 2019 Feb 19. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Blackwell Pub Country of Publication: Canada NLM ID: 101093910 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-4758 (Electronic) Linking ISSN: 14927535 NLM ISO Abbreviation: Hemodial Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003-> : Malden, MA : Blackwell Pub. Original Publication: Milton, ON : Multimed Inc., c2000- |
| مواضيع طبية MeSH: | Fatty Acids, Unsaturated/*adverse effects , Gastrointestinal Microbiome/*physiology , Renal Dialysis/*adverse effects , Renal Insufficiency, Chronic/*complications , Uremia/*etiology, Adolescent ; Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Renal Dialysis/methods ; Renal Insufficiency, Chronic/pathology ; Young Adult |
| مستخلص: | Introduction: Indoxyl sulfate (IS) and p-cresyl sulfate (p-CS) are albumin-bound uremic toxins that are difficult to remove by hemodialysis (HD). Human serum albumin (HSA) carries several compounds, including fatty acids that can bind to site II of HSA and represent competing ligands for uremic toxins. The aim of this study was to investigate the association between fatty acids and uremic toxin plasma levels in patients undergoing HD. Methods: Thirty-three HD patients (51.5% male, 54.9 ± 10.2 years old, 44.63 ± 28.4 months on HD, albumin level of 3.8 ± 0.3 g/dL) were evaluated. The erythrocyte fatty acid content (saturated fatty acid [SFA], monounsaturated fatty acid [MUFA], and polyunsaturated fatty acid [PUFA]) was measured by gas chromatography, and total IS and p-CS plasma levels were measured by reversed-phase high-performance liquid chromatography. Findings: The mean percentages of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) + DHA and gamma-linolenic (GLA) acid in the erythrocyte membrane were 1.35% ± 0.74%, 1.85% ± 0.79%, and 0.33% ± 0.26%, respectively. The mean levels of IS and p-CS were 19.4 ± 11.9 mg/dL and 101.5 ± 57.2 mg/dL, respectively. There was no significant association between SFA and MUFA and IS and p-CS; however, a negative correlation was found between p-CS and specific PUFAs, and the association between GLA and p-CS levels was retained after adjusting for potential confounding variables (β = -0.49, P = 0.007). Discussion: Polyunsaturated fatty acids may contribute to the decrease in p-CS uremic toxin plasma levels in patients with chronic kidney disease undergoing HD. (© 2019 International Society for Hemodialysis.) |
| معلومات مُعتمدة: | International Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); International Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); International Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) |
| فهرسة مساهمة: | Keywords: Human serum albumin; chronic kidney disease; fatty acid; hemodialysis; uremic toxins |
| المشرفين على المادة: | 0 (Fatty Acids, Unsaturated) |
| تواريخ الأحداث: | Date Created: 20190220 Date Completed: 20200529 Latest Revision: 20200529 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1111/hdi.12725 |
| PMID: | 30779317 |
| قاعدة البيانات: | MEDLINE |
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