دورية أكاديمية
A Biochemical Nickel(I) State Supports Nucleophilic Alkyl Addition: A Roadmap for Methyl Reactivity in Acetyl Coenzyme A Synthase.
العنوان: | A Biochemical Nickel(I) State Supports Nucleophilic Alkyl Addition: A Roadmap for Methyl Reactivity in Acetyl Coenzyme A Synthase. |
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المؤلفون: | Manesis AC; Department of Chemistry and Biochemistry , The Ohio State University , 100 W. 18th Avenue , Columbus , Ohio 43210 , United States., Musselman BW; Department of Chemistry , University of Michigan , 930 N. University Avenue , Ann Arbor , Michigan 48109 , United States., Keegan BC; Department of Chemistry , Trinity University , One Trinity Place , San Antonio , Texas 78212 , United States., Shearer J; Department of Chemistry , Trinity University , One Trinity Place , San Antonio , Texas 78212 , United States., Lehnert N; Department of Chemistry , University of Michigan , 930 N. University Avenue , Ann Arbor , Michigan 48109 , United States., Shafaat HS; Department of Chemistry and Biochemistry , The Ohio State University , 100 W. 18th Avenue , Columbus , Ohio 43210 , United States. |
المصدر: | Inorganic chemistry [Inorg Chem] 2019 Jul 15; Vol. 58 (14), pp. 8969-8982. Date of Electronic Publication: 2019 Feb 21. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 0366543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-510X (Electronic) Linking ISSN: 00201669 NLM ISO Abbreviation: Inorg Chem |
أسماء مطبوعة: | Original Publication: [Easton, Pa.] American Chemical Society. |
مواضيع طبية MeSH: | Acetyl Coenzyme A/*chemistry , Acetyl Coenzyme A/*metabolism , Nickel/*chemistry , Organometallic Compounds/*chemistry, Azurin/genetics ; Azurin/metabolism ; Catalysis ; Chromatography, Gas ; Gene Expression Regulation, Bacterial ; Kinetics ; Magnetic Phenomena ; Mutation ; Organometallic Compounds/metabolism ; Pseudomonas aeruginosa/enzymology ; Spectrum Analysis |
مستخلص: | Nickel-containing enzymes such as methyl coenzyme M reductase (MCR) and carbon monoxide dehydrogenase/acetyl coenzyme A synthase (CODH/ACS) play a critical role in global energy conversion reactions, with significant contributions to carbon-centered processes. These enzymes are implied to cycle through a series of nickel-based organometallic intermediates during catalysis, though identification of these intermediates remains challenging. In this work, we have developed and characterized a nickel-containing metalloprotein that models the methyl-bound organometallic intermediates proposed in the native enzymes. Using a nickel(I)-substituted azurin mutant, we demonstrate that alkyl binding occurs via nucleophilic addition of methyl iodide as a methyl donor. The paramagnetic Ni III -CH |
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معلومات مُعتمدة: | R15 GM120641 United States GM NIGMS NIH HHS |
المشرفين على المادة: | 0 (Organometallic Compounds) 12284-43-4 (Azurin) 72-89-9 (Acetyl Coenzyme A) 7OV03QG267 (Nickel) |
تواريخ الأحداث: | Date Created: 20190222 Date Completed: 20190809 Latest Revision: 20200225 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC6635881 |
DOI: | 10.1021/acs.inorgchem.8b03546 |
PMID: | 30788970 |
قاعدة البيانات: | MEDLINE |
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