دورية أكاديمية
Yersinia pestis Pla Protein Thwarts T Cell Defense against Plague.
| العنوان: | Yersinia pestis Pla Protein Thwarts T Cell Defense against Plague. |
|---|---|
| المؤلفون: | Smiley ST; Trudeau Institute, Saranac Lake, New York, USA., Szaba FM; Trudeau Institute, Saranac Lake, New York, USA., Kummer LW; Trudeau Institute, Saranac Lake, New York, USA., Duso DK; Trudeau Institute, Saranac Lake, New York, USA., Lin JS; Trudeau Institute, Saranac Lake, New York, USA jslin@trudeauinstitute.org. |
| المصدر: | Infection and immunity [Infect Immun] 2019 Apr 23; Vol. 87 (5). Date of Electronic Publication: 2019 Apr 23 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : American Society For Microbiology Original Publication: [Bethesda, Md.] American Society for Microbiology. |
| مواضيع طبية MeSH: | Fibrinolysis/*immunology , Plague/*immunology , Plasminogen Activators/*immunology , T-Lymphocytes/*immunology , Virulence Factors/*immunology , Yersinia pestis/*pathogenicity, Animals ; Disease Models, Animal ; Humans ; Mice ; Mice, Inbred C57BL |
| مستخلص: | Plague is a rapidly lethal human disease caused by the bacterium Yersinia pestis This study demonstrated that the Y. pestis plasminogen activator Pla, a protease that promotes fibrin degradation, thwarts T cell-mediated defense against fully virulent Y. pestis Introducing a single point mutation into the active site of Pla suffices to render fully virulent Y. pestis susceptible to primed T cells. Mechanistic studies revealed essential roles for fibrin during T cell-mediated defense against Pla-mutant Y. pestis Moreover, the efficacy of T cell-mediated protection against various Y. pestis strains displayed an inverse relationship with their levels of Pla activity. Together, these data indicate that Pla functions to thwart fibrin-dependent T cell-mediated defense against plague. Other important human bacterial pathogens, including staphylococci, streptococci, and borrelia, likewise produce virulence factors that promote fibrin degradation. The discovery that Y. pestis thwarts T cell defense by promoting fibrinolysis suggests novel therapeutic approaches to amplifying T cell responses against human pathogens. (Copyright © 2019 American Society for Microbiology.) |
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| معلومات مُعتمدة: | R01 AI061577 United States AI NIAID NIH HHS; R01 AI071295 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Pla; T cell-mediated protection; Yersinia pestis; YopE; fibrin; fibrin degradation; fibrinolysis; immunization; plague; plasminogen activator |
| المشرفين على المادة: | 0 (Virulence Factors) EC 3.4.21.- (Plasminogen Activators) |
| تواريخ الأحداث: | Date Created: 20190227 Date Completed: 20190916 Latest Revision: 20200309 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6479024 |
| DOI: | 10.1128/IAI.00126-19 |
| PMID: | 30804102 |
| قاعدة البيانات: | MEDLINE |
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