دورية أكاديمية
Mass-spectrometric assay of tocainide in serum.
| العنوان: | Mass-spectrometric assay of tocainide in serum. |
|---|---|
| المؤلفون: | Jones CW |
| المصدر: | Clinical chemistry [Clin Chem] 1986 Mar; Vol. 32 (3), pp. 503-5. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9421549 Publication Model: Print Cited Medium: Print ISSN: 0009-9147 (Print) Linking ISSN: 00099147 NLM ISO Abbreviation: Clin Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : Oxford : Oxford University Press Original Publication: Baltimore, Md. : P.B. Hoeber, [c1955- |
| مواضيع طبية MeSH: | Lidocaine/*analogs & derivatives, Gas Chromatography-Mass Spectrometry ; Humans ; Lidocaine/blood ; Pharmaceutical Preparations/blood ; Tocainide |
| مستخلص: | This mass-spectrometric method for assaying tocainide in serum is specific, reproducible, and sensitive, and sample preparation is rapid. The drug is isolated from serum by liquid-solid extraction on a Baker C18 disposable column. Underivatized drug is separated by elution on a 0.20 mm X 25 m fused-silica capillary column coated with 5% phenylmethylsilicone, then quantified by mass-selective detection (selected ion monitoring). Sample size is 1 mL of serum, but smaller volumes may be used. Mean analytical recovery of the drug from the disposable columns is 75%. Commonly used antiarrhythmics, sedatives, or hypnotics do not interfere. The run-to-run CV at 3.7 mg/L is 4.0%, 3.0% at 10.5 mg/L. |
| المشرفين على المادة: | 0 (Pharmaceutical Preparations) 27DXO59SAN (Tocainide) 98PI200987 (Lidocaine) |
| تواريخ الأحداث: | Date Created: 19860301 Date Completed: 19860403 Latest Revision: 20190722 |
| رمز التحديث: | 20240829 |
| PMID: | 3081283 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0009-9147 |
|---|