دورية أكاديمية
أعرض في EDS

Life in the cystic fibrosis upper respiratory tract influences competitive ability of the opportunistic pathogen Pseudomonas aeruginosa .

التفاصيل البيبلوغرافية
العنوان: Life in the cystic fibrosis upper respiratory tract influences competitive ability of the opportunistic pathogen Pseudomonas aeruginosa .
المؤلفون: Bara JJ; Department of Biology, University of Louisville, Louisville, KY, USA.; Department of Biology, Shenandoah University, Winchester, VA, USA., Matson Z; Department of Biology, University of Louisville, Louisville, KY, USA., Remold SK; Department of Biology, University of Louisville, Louisville, KY, USA.
المصدر: Royal Society open science [R Soc Open Sci] 2018 Sep 19; Vol. 5 (9), pp. 180623. Date of Electronic Publication: 2018 Sep 19 (Print Publication: 2018).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Royal Society Publishing Country of Publication: England NLM ID: 101647528 Publication Model: eCollection Cited Medium: Print ISSN: 2054-5703 (Print) Linking ISSN: 20545703 NLM ISO Abbreviation: R Soc Open Sci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Royal Society Publishing, 2014-
مستخلص: Understanding characteristic differences between host-associated and free-living opportunistic pathogens can provide insight into the fundamental requirements for success after dispersal to the host environment, and more generally into the ecological and evolutionary processes by which populations respond to simultaneous selection on complex interacting traits. We examined how cystic fibrosis (CF)-associated and environmental isolates of the opportunistic pathogen Pseudomonas aeruginosa differ in the production of an ecologically important class of proteinaceous toxins known as bacteriocins, and how overall competitive ability depends on the production of and resistance to these bacteriocins. We determined bacteriocin gene content in a diverse collection of environmental and CF isolates and measured bacteriocin-mediated inhibition, resistance and the outcome of competition in a shared environment between all possible pairs of these isolates at 25°C and 37°C. Although CF isolates encoded significantly more bacteriocin genes, our phenotypic assays suggest that they have diminished bacteriocin-mediated killing and resistance capabilities relative to environmental isolates, regardless of incubation temperature. Notably, however, although bacteriocin killing and resistance profiles significantly predicted head-to-head competitive outcomes, CF and environmental isolates did not differ significantly in their competitive ability. This suggests that the contribution of bacteriocins to competitive ability involves selection on other traits that may be pleiotropically linked to interference competition mediated by bacteriocins.
Competing Interests: The authors declare that they have no competing interests.
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فهرسة مساهمة: Keywords: Pseudomonas aeruginosa; bacteriocins; cystic fibrosis; host adaptation
سلسلة جزيئية: figshare 10.6084/m9.figshare.c.4222874
Dryad 10.5061/dryad.0m801b4
تواريخ الأحداث: Date Created: 20190307 Latest Revision: 20230928
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC6170537
DOI: 10.1098/rsos.180623
PMID: 30839703
قاعدة البيانات: MEDLINE
الوصف
تدمد:2054-5703
DOI:10.1098/rsos.180623