دورية أكاديمية
أعرض في EDS

The effect of non-TNF-targeted biologics on vascular dysfunction in rheumatoid arthritis: A systematic literature review.

التفاصيل البيبلوغرافية
العنوان: The effect of non-TNF-targeted biologics on vascular dysfunction in rheumatoid arthritis: A systematic literature review.
المؤلفون: Ursini F; Internal Medicine Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy. Electronic address: rsnfnc@unife.it., Ruscitti P; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., Caio GPI; Internal Medicine Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Manfredini R; Internal Medicine Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Giacomelli R; Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy., De Giorgio R; Internal Medicine Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
المصدر: Autoimmunity reviews [Autoimmun Rev] 2019 May; Vol. 18 (5), pp. 501-509. Date of Electronic Publication: 2019 Mar 04.
نوع المنشور: Journal Article; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128967 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-0183 (Electronic) Linking ISSN: 15689972 NLM ISO Abbreviation: Autoimmun Rev Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; New York : Elsevier, c2002-
مواضيع طبية MeSH: Antirheumatic Agents/*therapeutic use , Arthritis, Rheumatoid/*drug therapy , Vascular Diseases/*drug therapy, Abatacept/therapeutic use ; Antibodies, Monoclonal, Humanized/therapeutic use ; Arthritis, Rheumatoid/complications ; Biological Factors/therapeutic use ; Biological Products/therapeutic use ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Rituximab/therapeutic use ; Vascular Diseases/etiology
مستخلص: Background: Rheumatoid arthritis (RA) is burdened by a significant increase in cardiovascular disease (CVD) risk. Amongst CVD risk factors, endothelial dysfunction and arterial stiffness represent powerful predictors of atherosclerosis and cardiovascular events in the general population and in RA patients.
Methods: A systematic review of the literature was performed to identify the available data on the effect of non-TNF-targeted biologics licensed for the treatment of RA on endothelial function, arterial stiffness or subclinical atherosclerosis. MedLine (via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL) and Web of Science (WOS) databases were searched using a predefined strategy to identify relevant articles.
Results: The search strategy initially retrieved 389 records. After screening titles and abstracts, a total of 362 studies were excluded. Amongst the remaining 27 studies selected for final examination, 16 articles were included in the systematic literature review. Included studies demonstrated a significant effect of abatacept, anakinra, rituximab and tocilizumab in improving endothelial dysfunction associated with RA; the effect on arterial stiffness was less consistent and deserves further investigation. No significant effect of non-TNF-targeted biologics was observed for measures of subclinical atherosclerosis.
Conclusion: Non-TNF-targeted biologics have been associated with favorable effects on endothelial dysfunction as already demonstrated for TNF inhibitors. Future studies are needed to ascertain the impact of this mediations on arterial stiffness in RA patients.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Abatacept; Anakinra; Arterial stiffness; Endothelial dysfunction; Intima media thickness; Rituximab; Tocilizumab
المشرفين على المادة: 0 (Antibodies, Monoclonal, Humanized)
0 (Antirheumatic Agents)
0 (Biological Factors)
0 (Biological Products)
0 (Interleukin 1 Receptor Antagonist Protein)
4F4X42SYQ6 (Rituximab)
7D0YB67S97 (Abatacept)
I031V2H011 (tocilizumab)
تواريخ الأحداث: Date Created: 20190308 Date Completed: 20190531 Latest Revision: 20190531
رمز التحديث: 20240829
DOI: 10.1016/j.autrev.2019.03.008
PMID: 30844558
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-0183
DOI:10.1016/j.autrev.2019.03.008