دورية أكاديمية
Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients.
العنوان: | Comparison of 24-hour and Office Pulse Wave Velocity for Prediction of Mortality in Hemodialysis Patients. |
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المؤلفون: | Matschkal J; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany, julia.matschkal@gmx.de., Mayer CC; Center for Health & Bioresources, Biomedical Systems, AIT Austrian Institute of Technology, Vienna, Austria.; Institute for Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria., Sarafidis PA; Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Lorenz G; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Braunisch MC; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Guenthner R; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Angermann S; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Steubl D; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Kemmner S; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Bachmann Q; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Hauser C; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Nerl L; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Baumann M; Department of Nephrology, Internistische Fachklinik Dr. Steger, Nuremberg, Germany., Mann JF; KfH Dialysis Center Schwabing, Munich, Germany., Moog P; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Kuechle C; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Renders L; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Heemann U; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany., Wassertheurer S; Center for Health & Bioresources, Biomedical Systems, AIT Austrian Institute of Technology, Vienna, Austria.; Institute for Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria., Schmaderer C; Department of Nephrology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany. |
المصدر: | American journal of nephrology [Am J Nephrol] 2019; Vol. 49 (4), pp. 317-327. Date of Electronic Publication: 2019 Mar 27. |
نوع المنشور: | Comparative Study; Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Karger Country of Publication: Switzerland NLM ID: 8109361 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1421-9670 (Electronic) Linking ISSN: 02508095 NLM ISO Abbreviation: Am J Nephrol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Basel ; New York : Karger, [1981- |
مواضيع طبية MeSH: | Renal Dialysis*, Blood Pressure Monitoring, Ambulatory/*methods , Kidney Failure, Chronic/*mortality , Pulse Wave Analysis/*methods, Aged ; Female ; Follow-Up Studies ; Humans ; Kaplan-Meier Estimate ; Kidney Failure, Chronic/therapy ; Longitudinal Studies ; Male ; Middle Aged ; Office Visits ; Predictive Value of Tests ; Prognosis ; Prospective Studies ; Risk Assessment/methods ; Risk Factors |
مستخلص: | Background: Mortality in hemodialysis patients still remains unacceptably high. Enhanced arterial stiffness is a known cardiovascular risk factor, and pulse wave velocity (PWV) has proven to be a valid parameter to quantify risk. Recent studies showed controversial results regarding the prognostic significance of PWV for mortality in hemodialysis patients, which may be due to methodological issues, such as assessment of PWV in the office setting (Office-PWV). Method: This study cohort contains patients from the "Risk stratification in end-stage renal disease - the ISAR study," a multicenter prospective longitudinal observatory cohort study. We examined and compared the predictive value of ambulatory 24-hour PWV (24 h-PWV) and Office-PWV on mortality in a total of 344 hemodialysis patients. The endpoints of the study were all-cause and cardiovascular mortality. Survival analysis included Kaplan-Meier estimates and Cox regression analysis. Results: During a follow-up of 36 months, a total of 89 patients died, 35 patients due to cardiovascular cause. Kaplan-Meier estimates for tertiles of 24 h-PWV and Office-PWV were similarly associated with mortality. In univariate Cox regression analysis, 24 h-PWV and Office-PWV were equivalent predictors for all-cause and cardiovascular mortality. After adjustment for common risk factors, only 24 h-PWV remained solely predictive for all-cause mortality (hazard ratio 2.51 [95% CI 1.31-4.81]; p = 0.004). Conclusions: Comparing both measurements, 24 h-PWV is an independent predictor for all-cause-mortality in hemodialysis patients beyond Office-PWV. (© 2019 S. Karger AG, Basel.) |
فهرسة مساهمة: | Keywords: Ambulatory blood pressure monitoring; Arterial stiffness; Chronic hemodialysis; Mortality; Pulse wave velocity |
تواريخ الأحداث: | Date Created: 20190328 Date Completed: 20200527 Latest Revision: 20200527 |
رمز التحديث: | 20221213 |
DOI: | 10.1159/000499532 |
PMID: | 30917369 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1421-9670 |
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DOI: | 10.1159/000499532 |