دورية أكاديمية
Complete genome sequence of a divergent strain of Tibetan frog hepatitis B virus associated with a concave-eared torrent frog (Odorrana tormota).
| العنوان: | Complete genome sequence of a divergent strain of Tibetan frog hepatitis B virus associated with a concave-eared torrent frog (Odorrana tormota). |
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| المؤلفون: | Debat HJ; Instituto de Patología Vegetal, Centro de Investigaciones Agropecuarias, Instituto Nacional de Tecnología Agropecuaria (IPAVE-CIAP-INTA), X5020ICA, Córdoba, Argentina. debat.humberto@inta.gob.ar., Ng TFF; College of Veterinary Medicine, University of Georgia, Athens, GA, 30602, USA. |
| المصدر: | Archives of virology [Arch Virol] 2019 Jun; Vol. 164 (6), pp. 1727-1732. Date of Electronic Publication: 2019 Mar 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer-Verlag Country of Publication: Austria NLM ID: 7506870 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-8798 (Electronic) Linking ISSN: 03048608 NLM ISO Abbreviation: Arch Virol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wien, New York, Springer-Verlag. |
| مواضيع طبية MeSH: | Genome, Viral*, Hepatitis B/*virology , Hepatitis B virus/*genetics , Ranidae/*virology , Whole Genome Sequencing/*methods, Animals ; Base Sequence ; Female ; Hepatitis B/veterinary ; Hepatitis B virus/classification ; Male ; Phylogeny |
| مستخلص: | Viruses of the family Hepadnaviridae are characterized by partially dsDNA circular genomes of approximately 3.2 kb, which are reverse transcribed from RNA intermediates. Hepadnaviruses have a broad host range, which includes humans (hepatitis B virus), other mammals (genus Orthohepadnavirus), and birds (genus Avihepadnavirus). The known host specificity of hepadnaviruses has been expanded by reports of new viruses infecting fish, amphibians, and reptiles. Tibetan frog hepatitis B virus (TFHBV) was recently discovered in a member of the species Nanorana parkeri (family Dicroglossidae) from Tibet. To increase our understanding of hepadnaviruses that infect amphibian hosts, we identified the full-length genome of a divergent strain, TFHBV-Ot, associated with a concave-eared torrent frog (Odorrana tormota, family Ranidae) from China by searching deep-sequencing data. TFHBV-Ot shared a genomic organization and 76.6% overall genome sequence nucleotide identity with the prototype TFHBV associated with N. parkeri (TFHBV-Np). The pairwise amino acid sequence identity between the predicted gene products of TFHBV-Ot and TFHBV-Np ranged between 63.9% and 77.9%. Multiple tissue/organ-specific RNAseq datasets suggested a broad tropism of TFHBV, including muscle, gonads and brain. In addition, we provide information about putative virus-derived small RNAs from an amphibian hepadnavirus. The results presented here expand the known genetic diversity and host range of TFHBV to Ranidae frogs, and warrant an investigation of hepadnaviral infection of amphibian brains. |
| تواريخ الأحداث: | Date Created: 20190330 Date Completed: 20190603 Latest Revision: 20190603 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1007/s00705-019-04227-8 |
| PMID: | 30923967 |
| قاعدة البيانات: | MEDLINE |
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