دورية أكاديمية
Single-photon Emission Computed Tomography-Computed Tomography Using 99m Tc-labeled Leukocytes for Evaluating Infection Associated with a Cranial Implant in a Rhesus Macaque ( Macaca mulatta ).
| العنوان: | Single-photon Emission Computed Tomography-Computed Tomography Using 99m Tc-labeled Leukocytes for Evaluating Infection Associated with a Cranial Implant in a Rhesus Macaque ( Macaca mulatta ). |
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| المؤلفون: | Guerriero KA; Department of Comparative Medicine., Wilson SR; Department of Comparative Medicine, Email: steven.r.wilson@yale.edu., Sinusas AJ; Section of Cardiovascular Medicine, Department of Medicine, Yale Translational Research Imaging Center, Departments of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut., Saperstein L; Departments of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, Connecticut., Zeiss AJ; Department of Comparative Medicine. |
| المصدر: | Comparative medicine [Comp Med] 2019 May 01; Vol. 69 (3), pp. 249-256. Date of Electronic Publication: 2019 Apr 01. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for Laboratory Animal Science Country of Publication: United States NLM ID: 100900466 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2769-819X (Electronic) Linking ISSN: 15320820 NLM ISO Abbreviation: Comp Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Memphis, TN : American Association for Laboratory Animal Science, 2000- |
| مواضيع طبية MeSH: | Macaca mulatta*/surgery, Monkey Diseases/*diagnostic imaging , Prosthesis-Related Infections/*veterinary , Single Photon Emission Computed Tomography Computed Tomography/*veterinary , Skull/*diagnostic imaging , Skull/*surgery, Animals ; Brain/diagnostic imaging ; Brain/pathology ; Inflammation/diagnostic imaging ; Inflammation/etiology ; Inflammation/veterinary ; Leukocytes ; Male ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/etiology ; Osteomyelitis/veterinary ; Prostheses and Implants ; Prosthesis-Related Infections/complications ; Prosthesis-Related Infections/diagnostic imaging ; Radiopharmaceuticals ; Single Photon Emission Computed Tomography Computed Tomography/methods ; Skull/pathology ; Technetium Tc 99m Exametazime |
| مستخلص: | An adult male rhesus macaque ( Macaca mulatta ) that was enrolled in a study evaluating cognition and memory presented with suppurative exudate along the margins of a long-standing cranial implant that included a stainless-steel head post, plastic left-sided recording cylinder, and acrylic over a previously placed right-sided recording cylinder. Both cylinders were located at the level of the prefrontal cortex. After treatment comprising systemic antibiotics and daily cleaning with povidone-iodine for several months, the macaque underwent single-photon emission computed tomography-computed tomography (SPECT-CT) in which his neutrophils were labeled with 99m Tc-hexamethylpropylene amine oxime ( 99m Tc-HMPAO) to evalu- ate for active infection below the implant. Soft tissue inflammation and osteomyelitis were found at the site of the previous right-sided recording cylinder. Cephalosporin and tetracycline antibiotics were administered for 12 wk. Follow-up SPECT-CT imaging was then performed to evaluate response to medical treatment. Results indicated no change in the degrees of soft tissue inflammation and osteomyelitis associated with the right-sided recording cylinder site. SPECT-CT imaging was used to guide the surgical removal of the implant and debridement of the infected tissue. On removal of the entire cranial implant, the osteomyelitis and soft tissue inflammation observed on the pre- and posttreatment SPECT-CT scans were confirmed. In addition, a large cavitary defect through the calvarium with suppurative exudate was discovered below the base of the head post. Infection in this defect was not apparent on SPECT; however, the bony defect was confirmed on reevaluation of the CT images. We concluded that the infection in this defect was silent on SPECT due to the limited vascularization of the sur-rounding bone and the chronicity of the infection. This case study is the first to describe the use of SPECT-CT for evaluating soft tissue inflammation and osteomyelitis beneath a cranial implant in a NHP. |
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| معلومات مُعتمدة: | UL1 TR001863 United States TR NCATS NIH HHS |
| المشرفين على المادة: | 0 (Radiopharmaceuticals) 3B744AG22N (Technetium Tc 99m Exametazime) |
| تواريخ الأحداث: | Date Created: 20190403 Date Completed: 20200805 Latest Revision: 20200805 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC6591671 |
| DOI: | 10.30802/AALAS-CM-18-000123 |
| PMID: | 30935441 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2769-819X |
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| DOI: | 10.30802/AALAS-CM-18-000123 |