دورية أكاديمية
Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma?
| العنوان: | Are Comorbidities Associated With Overall Survival in Patients With Oral Squamous Cell Carcinoma? |
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| المؤلفون: | Jariod-Ferrer ÚM; Attending Surgeon, Department of Oral and Maxillofacial Surgery, Miguel Servet University Hospital, Fellow of European Board of Oro-Maxillo-Facial Surgery, Zaragoza, Spain. Electronic address: ursulajariodferrer@gmail.com., Arbones-Mainar JM; Senior Researcher, Instituto Aragonés de Ciencias de la Salud (IACS), Instituto de Investigación Sanitaria (IIS) Aragón, Zaragoza; CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Madrid, Spain., Gavin-Clavero MA; Attending Surgeon, Department of Oral and Maxillofacial Surgery, Miguel Servet University Hospital, Zaragoza, Spain., Simón-Sanz MV; Attending Surgeon, Department of Oral and Maxillofacial Surgery, Miguel Servet University Hospital, Zaragoza, Spain., Moral-Saez I; Department Head, Department of Oral and Maxillofacial Surgery, Miguel Servet University Hospital, Zaragoza, Spain., Cisneros-Gimeno AI; Professor, School of Medicine, University of Zaragoza, Zaragoza, Spain., Martinez-Trufero J; Attending Physician, Department of Clinical Oncology, Miguel Servet University Hospital, Zaragoza, Spain. |
| المصدر: | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [J Oral Maxillofac Surg] 2019 Sep; Vol. 77 (9), pp. 1906-1914. Date of Electronic Publication: 2019 Mar 19. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: W.B. Saunders Co Country of Publication: United States NLM ID: 8206428 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1531-5053 (Electronic) Linking ISSN: 02782391 NLM ISO Abbreviation: J Oral Maxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Philadelphia, PA : W.B. Saunders Co., c1982- |
| مواضيع طبية MeSH: | Carcinoma, Squamous Cell*/mortality , Carcinoma, Squamous Cell*/surgery , Mouth Neoplasms*/mortality , Mouth Neoplasms*/surgery, Adult ; Aged ; Aged, 80 and over ; Comorbidity ; Humans ; Middle Aged ; Neutrophils ; Prognosis ; Retrospective Studies |
| مستخلص: | Purpose: Oral squamous cell carcinoma (OSCC) is a highly prevalent type of immunogenic cancer with a low survival rate in patients with comorbidities owing to toxic habits. Materials and Methods: A retrospective cohort study was conducted of patients with resectable OSCC at a tertiary Spanish hospital from 2011 to 2014. The primary predictor variables were comorbidity and immune biomarkers. Comorbidity was assessed using the Adult Comorbidity Evaluation-27 (ACE-27) and scored from 1 to 3 (mild to severe decompensation, respectively). The immune biomarkers were neutrophil-to-lymphocyte ratio (NLR), derived NLR (dNLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR). The primary outcome variable was 5-year overall survival (OS). Other study variables were stage, margin, and neck management. Receiver operating characteristic curves were built for each ratio. For the survey of immune biomarkers, area under the curve was computed to determine cutoff points and investigate their association with OS. Kaplan-Meier estimates of survival and Cox proportional hazards models were used for longitudinal analysis. Results: Overall 215 patients were identified (median age, 67 yr; range, 32 to 96 yr; median follow-up, 31 months; range, 7 to 78 months); 159 patients had at least 1 comorbid condition. Results showed that a severe comorbidity (according to the ACE-27) increased the risk of death by 4 times in patients with OSCC regardless of stage. NLR, dNLR, LMR, and PLR were associated with OS in the univariate study. Cutoff points to predict increased mortality were 3, 1.9, 2.6, and 66 for NLR, dNLR, LMR, and PLR, respectively. Age, comorbidity, stage, margins, and management of the neck were important independent predictors of decreased OS in OSCC. PLR was marginally associated with OS in the multivariate model. Conclusion: These results suggest that comorbidity and NLR, dNLR, LMR, and PLR are associated with 5-year OS in patients with resectable OSCC. (Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20190414 Date Completed: 20200807 Latest Revision: 20200807 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.joms.2019.03.007 |
| PMID: | 30980811 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1531-5053 |
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| DOI: | 10.1016/j.joms.2019.03.007 |