دورية أكاديمية
أعرض في EDS

Hyaline fibrous involution of breast lobules: a histologic finding associated with germline BRCA mutation.

التفاصيل البيبلوغرافية
العنوان: Hyaline fibrous involution of breast lobules: a histologic finding associated with germline BRCA mutation.
المؤلفون: Lee HE; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Arshad M; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Brahmbhatt RD; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Hoskin TL; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Winham SJ; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA., Frost MH; Department of Medical Oncology, Mayo Clinic, Rochester, MN, USA., Radisky DC; Department of Cancer Biology, Mayo Clinic, Rochester, MN, USA., Denison LA; Department of Information Technology, Mayo Clinic, Rochester, MN, USA., Degnim AC; Department of Surgery, Mayo Clinic, Rochester, MN, USA., Visscher DW; Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. Visscher.Daniel@mayo.edu.
المصدر: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc [Mod Pathol] 2019 Sep; Vol. 32 (9), pp. 1263-1270. Date of Electronic Publication: 2019 Apr 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 8806605 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-0285 (Electronic) Linking ISSN: 08933952 NLM ISO Abbreviation: Mod Pathol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York] : Elsevier Inc.
Original Publication: Baltimore, MD : Williams & Wilkins, c1988-
مواضيع طبية MeSH: Hyalin*, BRCA1 Protein/*genetics , BRCA2 Protein/*genetics , Mammary Glands, Human/*pathology, Adult ; Aged ; Breast Neoplasms/epidemiology ; Breast Neoplasms/pathology ; Female ; Germ-Line Mutation ; Humans ; Middle Aged
مستخلص: We describe the histology and the frequency of a histologic entity that we term "hyaline fibrous involution", which is characterized by symmetric and regular deposition of basal lamina-like periacinar hyaline material in association with atrophic epithelium, in breast samples from patients with either benign breast disease or germline BRCA mutation. Women with germline BRCA mutation (n = 93) who underwent prophylactic mastectomy (BRCA group) were compared to an age-matched sample of women who underwent biopsy for benign breast disease (n = 93). Median age was 45 years (range, 25-72 years). A single H&E section of each subject's benign breast tissue was reviewed. The total number of terminal duct lobular units and the number of terminal duct lobular units with hyaline fibrous involution were recorded for each case. The presence of any hyaline fibrous involution lobules and the within-sample proportion of hyaline fibrous involution lobules relative to total lobules were compared between groups. Presence of any hyaline fibrous involution was significantly more frequent in the BRCA group compared to the benign breast disease group, 47% vs. 15% (p < 0.0001, adjusted for total lobules). In women with any hyaline fibrous involution lobules, these unusual lobules were similarly rare in both groups, with median proportion of hyaline fibrous involution-positive lobules relative to all lobules of 0.03 in BRCA specimens (n = 44) and 0.03 in the benign breast disease group (n = 14). Within the BRCA group, frequency of any hyaline fibrous involution present was significantly higher in the perimenopausal age group (45-55 years: 63%) compared to other age groups (<45 years, 44%; >55 years, 15%; p = 0.05 and p = 0.02, respectively). Increased presence of hyaline fibrous involution in the setting of BRCA mutation suggests that it may represent a pathologic entity, possibly reflecting abnormal involution or an abnormal response to DNA damage.
المشرفين على المادة: 0 (BRCA1 Protein)
0 (BRCA1 protein, human)
0 (BRCA2 Protein)
0 (BRCA2 protein, human)
تواريخ الأحداث: Date Created: 20190419 Date Completed: 20200706 Latest Revision: 20230210
رمز التحديث: 20231215
DOI: 10.1038/s41379-019-0217-9
PMID: 30996252
قاعدة البيانات: MEDLINE
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