دورية أكاديمية
A mouse model of cochlear implantation with chronic electric stimulation.
| العنوان: | A mouse model of cochlear implantation with chronic electric stimulation. |
|---|---|
| المؤلفون: | Claussen AD; Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA, United States of America., Vielman Quevedo R; Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA, United States of America., Mostaert B; Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA, United States of America., Kirk JR; Cochlear Americas, Centennial, CO, United States of America., Dueck WF; Cochlear Deutschland GmbH & Co. KG, Hannover, Germany., Hansen MR; Department of Otolaryngology-Head and Neck Surgery, University of Iowa, Iowa City, IA, United States of America.; Department of Neurosurgery, University of Iowa, Iowa City, IA, United States of America. |
| المصدر: | PloS one [PLoS One] 2019 Apr 18; Vol. 14 (4), pp. e0215407. Date of Electronic Publication: 2019 Apr 18 (Print Publication: 2019). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Public Library of Science |
| مواضيع طبية MeSH: | Cochlear Implantation* , Cochlear Implants* , Deafness*/physiopathology , Deafness*/therapy , Electric Stimulation Therapy* , Evoked Potentials, Auditory, Brain Stem*, Animals ; Disease Models, Animal ; Female ; Humans ; Male ; Mice |
| مستخلص: | Objectives: Cochlear implants provide an effective treatment option for those with severe hearing loss, including those with preserved low frequency hearing. However, certain issues can reduce implant efficacy including intracochlear tissue response and delayed loss of residual acoustic hearing. We describe a mouse model of cochlear implantation with chronic electric stimulation that can be used to study cochlear implant biology and related pathologies. Methods: Twelve normal hearing adult CBA/J mice underwent unilateral cochlear implantation and were evenly divided into one group receiving electric stimulation and one not. Serial impedance and neural response telemetry (NRT) measurements were made to assess implant functionality. Functionality was defined as having at least one electrode with an impedance ≤ 35 kOhms. Mouse cochleae were harvested for histology and 3D x-ray microscopy 21 days post-operatively, or, in case the implant was still functional, at a later time point when the implant failed. A separate experiment measured the hearing preservation rate in 7 adult CBA/J mice undergoing unilateral cochlear implantation with serial auditory brainstem response (ABR) and distortion product otoacoustic emissions (DPOAE). Results: Implants maintained functionality for a mean of 35 days in the non-stimulated group and 19.8 days in the stimulated group. Reliable NRT and behavioral responses to electric stimulation were recorded. A robust intracochlear peri-implant tissue response with neo-ossification was seen in all cochleae. Six of seven mice maintained intact low frequency hearing up to 6 weeks following cochlear implantation. Conclusions: We demonstrate the feasibility of cochlear implantation and behaviorally significant electric stimulation in the mouse, with the potential for hearing preservation. This model may be combined with established mouse models of hearing loss and the large genetic and molecular research toolkit unique to the mouse for mechanistic and therapeutic investigations of cochlear implant biology. Competing Interests: This research was partially funded by and performed in collaboration with Cochlear Americas as research partners, with no financial or non-financial influence dependent on the outcome or reporting and sharing of data. JK and WD are employed by the Cochlear Corporation. MH is a co-founder and Chief Medical Officer of iotaMotion Inc with equity interest. These roles do not alter the author's adherence to PLOS ONE reporting and data sharing guidelines or the decision to report data. |
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| معلومات مُعتمدة: | R01 DC012578 United States DC NIDCD NIH HHS; S10 OD018503 United States OD NIH HHS; UL1 TR002537 United States TR NCATS NIH HHS; T32 DC000040 United States DC NIDCD NIH HHS |
| سلسلة جزيئية: | Dryad 10.5061/dryad.m4d38rp |
| تواريخ الأحداث: | Date Created: 20190419 Date Completed: 20200107 Latest Revision: 20220512 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6472764 |
| DOI: | 10.1371/journal.pone.0215407 |
| PMID: | 30998726 |
| قاعدة البيانات: | MEDLINE |
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