تقرير
Multiple subacute bilateral cerebral infarcts in a 9-year-old Nigerian male: a case of childhood primary angiitis of the central nervous system.
| العنوان: | Multiple subacute bilateral cerebral infarcts in a 9-year-old Nigerian male: a case of childhood primary angiitis of the central nervous system. |
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| المؤلفون: | Ogoke CC; Children's Emergency Room (CHER), Ward 12 (children's in-patient ward) and the Paediatric Neurology Clinic, Federal Medical Centre, Owerri, Nigeria., Ike II; Children's Emergency Room (CHER), Ward 12 (children's in-patient ward) and the Paediatric Neurology Clinic, Federal Medical Centre, Owerri, Nigeria., Osuji AE; Children's Emergency Room (CHER), Ward 12 (children's in-patient ward) and the Paediatric Neurology Clinic, Federal Medical Centre, Owerri, Nigeria., Asinobi K; Children's Emergency Room (CHER), Ward 12 (children's in-patient ward) and the Paediatric Neurology Clinic, Federal Medical Centre, Owerri, Nigeria., Okeke CE; Children's Emergency Room (CHER), Ward 12 (children's in-patient ward) and the Paediatric Neurology Clinic, Federal Medical Centre, Owerri, Nigeria. |
| المصدر: | The Pan African medical journal [Pan Afr Med J] 2018 Oct 10; Vol. 31, pp. 99. Date of Electronic Publication: 2018 Oct 10 (Print Publication: 2018). |
| نوع المنشور: | Case Reports |
| اللغة: | English |
| بيانات الدورية: | Publisher: African Field Epidemiology Network Country of Publication: Uganda NLM ID: 101517926 Publication Model: eCollection Cited Medium: Internet ISSN: 1937-8688 (Electronic) NLM ISO Abbreviation: Pan Afr Med J Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Kampala, Uganda : African Field Epidemiology Network |
| مواضيع طبية MeSH: | Cerebral Infarction/*etiology , Immunosuppressive Agents/*therapeutic use , Vasculitis, Central Nervous System/*diagnosis, Cerebral Infarction/diagnostic imaging ; Cerebral Infarction/drug therapy ; Child ; Humans ; Male ; Neuroimaging/methods ; Nigeria ; Treatment Outcome ; Vasculitis, Central Nervous System/complications ; Vasculitis, Central Nervous System/drug therapy |
| مستخلص: | A Primary Angiitis of the Central Nervous System (PACNS) is ill-defined, complex and rare in children. Clinical presentation is variable, diagnosis is challenging and it is life-threatening but treatable. The index case is a 9-year old male who presented with progressively slurred speech, progressive weakness of the limbs, hemifacial weakness and vomiting. There were no clinical or laboratory features of systemic vasculitis. Neuroimaging showed multiple subacute infarcts in both cerebral hemispheres. He responded well to immunosuppressive therapy. The case report aims to underscore the need for high index of suspicion, early neuroimaging for progressive nonspecific decline in neurologic function and the treatable nature of the condition if diagnosis is made early. Competing Interests: The authors declare no competing interests. |
| References: | J Rheumatol. 2001 Mar;28(3):616-23. (PMID: 11296969) Neurology. 2001 Apr 10;56(7):837-42. (PMID: 11314698) J Pediatr. 2004 Nov;145(5):693-7. (PMID: 15520782) Arthritis Rheum. 2005 Jul;52(7):2159-67. (PMID: 15986347) Arthritis Rheum. 2006 Apr;54(4):1291-7. (PMID: 16575852) Pediatr Nephrol. 2006 Sep;21(9):1219-22. (PMID: 16821024) |
| فهرسة مساهمة: | Keywords: Primary CNS vasculitis; aphasia; cerebral infarcts; childhood PACNS; progressive limb weakness |
| المشرفين على المادة: | 0 (Immunosuppressive Agents) |
| SCR Disease Name: | Primary angiitis of the central nervous system |
| تواريخ الأحداث: | Date Created: 20190424 Date Completed: 20190430 Latest Revision: 20200225 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC6462305 |
| DOI: | 10.11604/pamj.2018.31.99.13898 |
| PMID: | 31011399 |
| قاعدة البيانات: | MEDLINE |
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