دورية أكاديمية
أعرض في EDS

Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing.

التفاصيل البيبلوغرافية
العنوان: Development and evaluation of a vegetable oil blend formulation for cutaneous wound healing.
المؤلفون: Guidoni M; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil., Figueira MM; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil., Ribeiro GP; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil., Lenz D; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil., Grizotto PA; Instituto de Química de São Carlos-IQSC, Universidade de São Paulo-USP, São Carlos, São Paulo, Brazil., de Melo Costa Pereira T; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil., Scherer R; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil., Bogusz S Jr; Instituto de Química de São Carlos-IQSC, Universidade de São Paulo-USP, São Carlos, São Paulo, Brazil., Fronza M; Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha-UVV, Av. Comissário José Dantas de Melo, no. 21, Boa Vista, Vila Velha, Espírito Santo, 29102-920, Brazil. marcio.fronza@uvv.br.
المصدر: Archives of dermatological research [Arch Dermatol Res] 2019 Aug; Vol. 311 (6), pp. 443-452. Date of Electronic Publication: 2019 Apr 22.
نوع المنشور: Evaluation Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 8000462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-069X (Electronic) Linking ISSN: 03403696 NLM ISO Abbreviation: Arch Dermatol Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin : Springer Verlag
مواضيع طبية MeSH: Collagen/*biosynthesis , Plant Oils/*therapeutic use , Skin/*injuries , Wound Healing/*drug effects, Administration, Cutaneous ; Animals ; Flax/chemistry ; Helianthus/chemistry ; Interleukin-1/metabolism ; Interleukin-6/metabolism ; Macadamia/chemistry ; Male ; Olea/chemistry ; Rats ; Rats, Wistar ; Ribes/chemistry ; Rosa/chemistry ; Tumor Necrosis Factor-alpha/metabolism ; Wound Healing/physiology
مستخلص: This work aimed to evaluate the in vivo capacity of a vegetable oil blend formulation (VOB) developed to accelerate cutaneous wound closure. Total thickness wounds were punctured on the skin on the back side of each animal and topically treated with the VOB formulation, Dersani ® ointment or the vehicle control. After 2, 7, 14, 21 days post-wounding, five animals from each group were euthanized, and the rates of wound closure and re-epithelialization were evaluated. The wounds were harvested for histological and biochemical analysis. VOB resulted in faster and greater re-epithelialization in the in vivo excisional wounds, exhibiting significant wound area reduction of 8.9, 8.0, 35.1, 45.2 and 47.0% after 2, 5, 10, 14 and 21 days post-wounding, respectively, when compared with the vehicle control. Histological and biochemical analyses showed that the VOB-treated wounds exhibited a significant increase of granular tissue and controlled inflammatory response by modulation of the release of pro-inflammatory cytokines TNF-α, IL-6 and IL-1. Moreover, VOB-treated wounds showed a significant and concrete increase in the deposition and organisation of collagen fibres in the wound site and improved the quality of the scar tissue. Altogether, these data revealed that VOB accelerates wound healing processes and might be beneficial for treating wound disorders.
فهرسة مساهمة: Keywords: Collagen; Cytokines; Fatty acids; Inflammation; Vegetable oil; Wound healing
المشرفين على المادة: 0 (Il6 protein, rat)
0 (Interleukin-1)
0 (Interleukin-6)
0 (Plant Oils)
0 (Tumor Necrosis Factor-alpha)
9007-34-5 (Collagen)
تواريخ الأحداث: Date Created: 20190424 Date Completed: 20191212 Latest Revision: 20191217
رمز التحديث: 20221213
DOI: 10.1007/s00403-019-01919-8
PMID: 31011875
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-069X
DOI:10.1007/s00403-019-01919-8