دورية أكاديمية
The functional changes of the circadian system organization in aging.
| العنوان: | The functional changes of the circadian system organization in aging. |
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| المؤلفون: | Zhao J; Department of Anaesthesiology, School of Medicine, The University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand., Warman GR; Department of Anaesthesiology, School of Medicine, The University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand., Cheeseman JF; Department of Anaesthesiology, School of Medicine, The University of Auckland, Park Road, Grafton, Auckland, 1023, New Zealand. Electronic address: j.cheeseman@auckland.ac.nz. |
| المصدر: | Ageing research reviews [Ageing Res Rev] 2019 Jul; Vol. 52, pp. 64-71. Date of Electronic Publication: 2019 Apr 29. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Elsevier Science, c2002- |
| مواضيع طبية MeSH: | Aging/*physiology , Circadian Clocks/*physiology, Animals ; CLOCK Proteins/genetics ; Circadian Rhythm ; Humans ; Suprachiasmatic Nucleus/physiology |
| مستخلص: | The circadian clock drives periodic oscillations at different levels of an organism from genes to behavior. This timing system is highly conserved across species from insects to mammals and human beings. The question of how the circadian clock is involved in the aging process continues to attract more attention. We aim to characterize the detrimental impact of aging on the circadian clock organization. We review studies on different components of the circadian clock at the central and periperal levels, and their changes in aged rodents and humans, and the fruit fly Drosophila. Intracellular signaling, cellular activity and intercellular coupling in the central pacemaker have been found to decline with advancing age. Evidence of degradation of the molecular clockwork reflected by clock gene expression in both central and peripheral oscillators due to aging is inadequate. The findings on age-associated molecular and functional changes of peripheral clocks are mixed. We conclude that aging can affect the circadian clock organization at various levels, and the impairment of the central network may be a fundamental mechanism of circadian disruption seen in aged species. (Copyright © 2019 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Central and peripheral oscillators; Circadian network; Circadian rhythms; Clock genes; Suprachiasmatic nuclei |
| المشرفين على المادة: | EC 2.3.1.48 (CLOCK Proteins) |
| تواريخ الأحداث: | Date Created: 20190504 Date Completed: 20200309 Latest Revision: 20200309 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.arr.2019.04.006 |
| PMID: | 31048031 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1872-9649 |
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| DOI: | 10.1016/j.arr.2019.04.006 |