دورية أكاديمية
Cellular immune responses against natural human papillomavirus infections among men in Kisumu, Kenya.
| العنوان: | Cellular immune responses against natural human papillomavirus infections among men in Kisumu, Kenya. |
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| المؤلفون: | Ondondo RO; Department of Medical Laboratory Sciences, Masinde Muliro University of Science and Technology, Kakamega, Kenya; Kenya Medical Research Institute, Nairobi, Kenya; Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya; Division of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, San Francisco, CA, USA. Electronic address: rondondo@mmust.ac.ke., Bukusi EA; Kenya Medical Research Institute, Nairobi, Kenya., Ng'ang'a ZW; Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya., Kiptoo M; Kenya Medical Research Institute, Nairobi, Kenya; Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya., Mpoke S; Kenya Medical Research Institute, Nairobi, Kenya. |
| المصدر: | Clinical immunology (Orlando, Fla.) [Clin Immunol] 2020 Mar; Vol. 212, pp. 108211. Date of Electronic Publication: 2019 May 02. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Academic Press Country of Publication: United States NLM ID: 100883537 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-7035 (Electronic) Linking ISSN: 15216616 NLM ISO Abbreviation: Clin Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Orlando, FL : Academic Press, c1999- |
| مواضيع طبية MeSH: | Immunity, Cellular/*immunology , Interferon-gamma/*immunology , Interleukin-2/*immunology , Papillomavirus Infections/*immunology , Th1 Cells/*immunology, Adult ; Case-Control Studies ; Cohort Studies ; Cytokines ; Disease Progression ; Humans ; Kenya ; Leukocytes, Mononuclear ; Male ; Papillomaviridae/genetics ; Papillomavirus Infections/virology ; Prospective Studies ; Up-Regulation ; Young Adult |
| مستخلص: | Human papillomavirus (HPV) is associated with ano-genital and cervical cancer. Persistence of oncogenic HPV genotypes is a requirement for development and progression of malignancies. Although, >70% of women clear incident HPV infections, data on natural history and HPV immunology among men is limited. To evaluate cell-mediated immune responses to natural HPV infections among men, we assessed cytokine responses on PBMCs collected from men with persistent or cleared HPV. Men with HPV clearance and those with HPV persistence had increased odds (6-times and 3-times respectively) of mounting cytokine responses compared to HPV uninfected men. Th1 cytokines IFN-γ (5.1-fold) and IL-2 (4.2-fold) were significantly (p < 0.0001) upregulated among men with HPV clearance compared to HPV uninfected men. Among men with HPV clearance compared to those with persistent HPV infection, only IFN-γ (2.4-fold) and IL-2 (3.0-fold) were significantly (p < 0.0001) upregulated. Th1 cell-mediated cytokine response was associated with natural HPV clearance in men. (Copyright © 2019. Published by Elsevier Inc.) |
| معلومات مُعتمدة: | P30 AI027763 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: Cellular immunity; Cytokine; HPV; Men; Natural immune responses |
| المشرفين على المادة: | 0 (Cytokines) 0 (IFNG protein, human) 0 (IL2 protein, human) 0 (Interleukin-2) 82115-62-6 (Interferon-gamma) |
| تواريخ الأحداث: | Date Created: 20190506 Date Completed: 20201019 Latest Revision: 20201019 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.clim.2019.05.001 |
| PMID: | 31054968 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1521-7035 |
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| DOI: | 10.1016/j.clim.2019.05.001 |