دورية أكاديمية
Tubular Injury and Dendritic Cell Activation Are Integral Components of Light Chain-Associated Acute Tubulointerstitial Nephritis.
| العنوان: | Tubular Injury and Dendritic Cell Activation Are Integral Components of Light Chain-Associated Acute Tubulointerstitial Nephritis. |
|---|---|
| المؤلفون: | Cheng M; From the Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento (Dr Cheng); and the Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport (Drs Gu, Turbat-Herrera, and Herrera)., Gu X; From the Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento (Dr Cheng); and the Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport (Drs Gu, Turbat-Herrera, and Herrera)., Turbat-Herrera EA; From the Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento (Dr Cheng); and the Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport (Drs Gu, Turbat-Herrera, and Herrera)., Herrera GA; From the Department of Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento (Dr Cheng); and the Department of Pathology and Translational Pathobiology, Louisiana State University Health Sciences Center, Shreveport (Drs Gu, Turbat-Herrera, and Herrera). |
| المصدر: | Archives of pathology & laboratory medicine [Arch Pathol Lab Med] 2019 Oct; Vol. 143 (10), pp. 1212-1224. Date of Electronic Publication: 2019 May 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: College of American Pathologists Country of Publication: United States NLM ID: 7607091 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-2165 (Electronic) Linking ISSN: 00039985 NLM ISO Abbreviation: Arch Pathol Lab Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northfield, Ill. : College of American Pathologists Original Publication: Chicago, American Medical Assn. |
| مواضيع طبية MeSH: | Nephritis, Interstitial/*pathology, Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; Dendritic Cells/immunology ; Female ; Fluorescent Antibody Technique ; Humans ; Immunohistochemistry ; Inflammation/pathology ; Kidney Tubules, Proximal/immunology ; Kidney Tubules, Proximal/pathology ; Male ; Microscopy, Electron ; Middle Aged ; Nephritis, Interstitial/immunology |
| مستخلص: | Context.—: Light chain-associated acute tubulointerstitial nephritis (LC-ATIN) is a variant of light chain proximal tubulopathy (LCPT). It is characterized by interstitial inflammation with tubulitis and deposition of monoclonal light chains in the tubulointerstitium. LC-ATIN is a rather poorly recognized pattern of LCPT and not much is known about this entity. Objective.—: To determine the clinicopathologic features of patients with LC-ATIN and investigate the proximal tubular injury and mechanism of interstitial inflammation in LC-ATIN. Design.—: A total of 38 cases of LC-ATIN were identified from the archives of 5043 renal biopsy specimens. In all cases, routine light microscopic examination, immunofluorescence, and electron microscopic examination were performed. In selected cases, immunofluorescent staining of dendritic cells and immunohistochemical staining for 4 tubular injury markers-KIM-1, p53, bcl-2, and Ki-67-were performed. Results.—: A characteristic finding in LC-ATIN cases was immunofluorescence staining of monoclonal light chains along tubular basement membranes in linear fashion and inside proximal tubular cells with a granular pattern. No monoclonal light chains were present in glomerular or vascular compartments confirmed with immunofluorescence, electron microscopy, and ultrastructural gold labeling. Ten of 15 LC-ATIN cases (67%) were concurrently positive for the 4 tubular injury markers. Dendritic cells were identified within the tubulointerstitium in the renal biopsy specimens, interacting with surrounding tubules with light-chain deposits and inflammatory cells. Conclusions.—: Significant proximal tubular injury occurs associated with LC-ATIN, and the monoclonal light chains accumulated in proximal tubular cells contribute to the injury. Dendritic cells are involved in the pathogenesis of interstitial inflammation in LC-ATIN. |
| المشرفين على المادة: | 0 (Biomarkers) |
| SCR Disease Name: | Acute Tubulointerstitial Nephritis |
| تواريخ الأحداث: | Date Created: 20190508 Date Completed: 20200420 Latest Revision: 20200420 |
| رمز التحديث: | 20240628 |
| DOI: | 10.5858/arpa.2018-0032-OA |
| PMID: | 31063013 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder كن أول من يترك تعليقا!