دورية أكاديمية
Liver stage malaria infection is controlled by host regulators of lipid peroxidation.
| العنوان: | Liver stage malaria infection is controlled by host regulators of lipid peroxidation. |
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| المؤلفون: | Kain HS; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA., Glennon EKK; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Seattle Children's Research Institute, Seattle, WA, USA., Vijayan K; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Seattle Children's Research Institute, Seattle, WA, USA., Arang N; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Department of Biomedical Sciences, University of California, San Diego, La Jolla, CA, USA., Douglass AN; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Pathobiology Program, University of Washington, Seattle, WA, USA., Fortin CL; Departments of Bioengineering & Pathology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Zuck M; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Seattle Children's Research Institute, Seattle, WA, USA., Lewis AJ; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA., Whiteside SL; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Seattle Children's Research Institute, Seattle, WA, USA., Dudgeon DR; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA., Johnson JS; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA., Aderem A; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA.; Seattle Children's Research Institute, Seattle, WA, USA.; Department of Immunology, University of Washington, Seattle, WA, USA., Stevens KR; Departments of Bioengineering & Pathology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Kaushansky A; Center for Infectious Disease Research, Seattle Biomedical Research Institute, Seattle, WA, USA. alexis.kaushansky@seattlechildrens.org.; Seattle Children's Research Institute, Seattle, WA, USA. alexis.kaushansky@seattlechildrens.org.; Department of Global Health, University of Washington, Seattle, WA, USA. alexis.kaushansky@seattlechildrens.org. |
| المصدر: | Cell death and differentiation [Cell Death Differ] 2020 Jan; Vol. 27 (1), pp. 44-54. Date of Electronic Publication: 2019 May 07. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9437445 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5403 (Electronic) Linking ISSN: 13509047 NLM ISO Abbreviation: Cell Death Differ Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2003->: London : Nature Publishing Group Original Publication: London : Edward Arnold, c1994- |
| مواضيع طبية MeSH: | Lipid Peroxidation*, Amino Acid Transport System y+/*metabolism , Liver Diseases/*metabolism , Liver Diseases/*parasitology , Malaria/*metabolism, Amino Acid Transport System y+/antagonists & inhibitors ; Animals ; Cell Line ; Cells, Cultured ; Ferroptosis ; Mice, Inbred C57BL ; Mice, Knockout ; NADPH Oxidase 1/genetics ; Phospholipid Hydroperoxide Glutathione Peroxidase/antagonists & inhibitors ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, Transferrin/metabolism ; Signal Transduction ; Tumor Suppressor Protein p53/metabolism |
| مستخلص: | The facets of host control during Plasmodium liver infection remain largely unknown. We find that the SLC7a11-GPX4 pathway, which has been associated with the production of reactive oxygen species, lipid peroxidation, and a form of cell death called ferroptosis, plays a critical role in control of Plasmodium liver stage infection. Specifically, blocking GPX4 or SLC7a11 dramatically reduces Plasmodium liver stage parasite infection. In contrast, blocking negative regulators of this pathway, NOX1 and TFR1, leads to an increase in liver stage infection. We have shown previously that increased levels of P53 reduces Plasmodium LS burden in an apoptosis-independent manner. Here, we demonstrate that increased P53 is unable to control parasite burden during NOX1 or TFR1 knockdown, or in the presence of ROS scavenging or when lipid peroxidation is blocked. Additionally, SLC7a11 inhibitors Erastin and Sorafenib reduce infection. Thus, blocking the host SLC7a11-GPX4 pathway serves to selectively elevate lipid peroxides in infected cells, which localize within the parasite and lead to the elimination of liver stage parasites. |
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| معلومات مُعتمدة: | T32 AI007509 United States AI NIAID NIH HHS; R01 AI032972 United States AI NIAID NIH HHS; U19 AI100627 United States AI NIAID NIH HHS; R01 GM101183 United States GM NIGMS NIH HHS; R00 AI111785 United States AI NIAID NIH HHS; R01 AI025032 United States AI NIAID NIH HHS |
| المشرفين على المادة: | 0 (Amino Acid Transport System y+) 0 (Reactive Oxygen Species) 0 (Receptors, Transferrin) 0 (Slc7a11 protein, mouse) 0 (Tfrc protein, mouse) 0 (Trp53 protein, mouse) 0 (Tumor Suppressor Protein p53) EC 1.11.1.12 (Phospholipid Hydroperoxide Glutathione Peroxidase) EC 1.11.1.9 (glutathione peroxidase 4, mouse) EC 1.6.3.- (NADPH Oxidase 1) EC 1.6.3.- (NOX1 protein, mouse) |
| تواريخ الأحداث: | Date Created: 20190509 Date Completed: 20210402 Latest Revision: 20220825 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7206113 |
| DOI: | 10.1038/s41418-019-0338-1 |
| PMID: | 31065106 |
| قاعدة البيانات: | MEDLINE |
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